CTNNAL1

CTNNAL1
Identifiers
Aliases	CTNNAL1 , ACRP, CLLP, alpha-CATU, catenin alpha like 1
External IDs	OMIM: 604785 MGI: 1859649 HomoloGene: 2815 GeneCards: CTNNAL1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	109,013,522 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	56,865,188 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• actin filament binding ; • GO:0001948 protein binding ; • cadherin binding ;
Cellular component	• cytoplasm ; • cytosol ; • cell membrane ; • cytoskeleton ; • membrane ;
Biological process	• cell adhesion ; • Rho protein signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	8727
	54366
	ENSG00000119326
	ENSMUSG00000038816
	Q9UBT7
	O88327
	NM_001286974 ; NM_003798
	NM_018761
	NP_001273903 ; NP_003789
	NP_061231
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 15, 2020

Alpha-catulin is a protein that in humans is encoded by the CTNNAL1 gene.^[5]^[6]

Interactions

CTNNAL1 has been shown to interact with AKAP13.^[7]

Related Research Articles

Alpha-catenin functions as the primary protein link between cadherins and the actin cytoskeleton. It has been reported that the actin binding proteins vinculin and alpha-actinin can bind to alpha-catenin. It has been suggested that alpha-catenin does not bind with high affinity to both actin filaments and the E-cadherin-beta-catenin complex at the same time. It has been observed that when alpha-catenin is not in a molecular complex with beta-catenin, it dimerizes and functions to regulate actin filament assembly, possibly by competing with Arp2/3 protein. Alpha catenin exhibits significant protein dynamics.

Beta-catenin-interacting protein 1 is a protein that is encoded in humans by the CTNNBIP1 gene.

N-cadherin, also known as Cadherin-2 (CDH2) or neural cadherin (NCAD) is a protein that in humans is encoded by the CDH2 gene. CDH2 has also been designated as CD325. N-cadherin is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac muscle, N-cadherin is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes. While mutations in CDH2 have not thus far been associated with human disease, alterations in expression and integrity of N-cadherin protein has been observed in various forms of disease, including human dilated cardiomyopathy.

Hypoxia-inducible factor 3 alpha is a protein that in humans is encoded by the HIF3A gene.

Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.

Cadherin EGF LAG seven-pass G-type receptor 1 also known as flamingo homolog 2 or cadherin family member 9 is a protein that in humans is encoded by the CELSR1 gene.

Catenin delta-1 is a protein that in humans is encoded by the CTNND1 gene.

Cadherin-3, also known as P-Cadherin, is a protein that in humans is encoded by the CDH3 gene.

A-kinase anchor protein 13 is an protein that in humans is encoded by the AKAP13 gene. This protein is also called AKAP-Lbc because it encodes the lymphocyte blast crisis (Lbc) oncogene, and ARHGEF13/RhoGEF13 because it contains a guanine nucleotide exchange factor (GEF) domain for the RhoA small GTP-binding protein.

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

Translation initiation factor eIF-2B subunit gamma is a protein that in humans is encoded by the EIF2B3 gene.

Transcriptional regulator Kaiso is a protein that in humans is encoded by the ZBTB33 gene. This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2, which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.

Cadherin-15 is a protein that in humans is encoded by the CDH15 gene.

Receptor-type tyrosine-protein phosphatase T is an enzyme that in humans is encoded by the PTPRT gene.

Rho guanine nucleotide exchange factor (GEF) 3, also known as ARHGEF3, is a human gene.

IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP₁₀₀ (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa) is a protein that in humans is encoded by the IQSEC1 gene.

Cadherin-1 also known as CAM 120/80 or epithelial cadherin (E-cadherin) or uvomorulin is a protein that in humans is encoded by the CDH1 gene. CDH1 has also been designated as CD324. It is a tumor suppressor gene.

αE-catenin, also known as Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene. αE-catenin is highly expressed in cardiac muscle and localizes to adherens junctions at intercalated disc structures where it functions to mediate the anchorage of actin filaments to the sarcolemma. αE-catenin also plays a role in tumor metastasis and skin cell function.

Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000119326 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038816 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhang JS, Nelson M, Wang L, Liu W, Qian CP, Shridhar V, Urrutia R, Smith DI (Jan 1999). "Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin". Genomics. 54 (1): 149–54. doi:10.1006/geno.1998.5458. PMID 9806841.
↑ "Entrez Gene: CTNNAL1 catenin (cadherin-associated protein), alpha-like 1".
↑ Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, Tosolini A, Testa JR, Toksoz D (Nov 2002). "Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation". J. Biol. Chem. 277 (47): 45361–70. doi: 10.1074/jbc.M202447200 . PMID 12270917.

External links

Human CTNNAL1 genome location and CTNNAL1 gene details page in the UCSC Genome Browser .

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Janssens B, Staes K, van Roy F (1999). "Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing". Biochim. Biophys. Acta. 1447 (2–3): 341–7. doi:10.1016/s0167-4781(99)00170-0. PMID 10542337.
Demacio PC, Ray PN (2002). "Alpha-catulin maps to the familial dysautonomia region on 9q31". Genome. 44 (6): 990–4. doi:10.1139/gen-44-6-990. PMID 11768226.
Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, Tosolini A, Testa JR, Toksoz D (2003). "Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation". J. Biol. Chem. 277 (47): 45361–70. doi: 10.1074/jbc.M202447200 . PMID 12270917.
Shieh YS, Chang LC, Chiu KC, Wu CW, Lee HS (2003). "Cadherin and catenin expression in mucoepidermoid carcinoma: correlation with histopathologic grade, clinical stage, and patient outcome". J. Oral Pathol. Med. 32 (5): 297–304. doi:10.1034/j.1600-0714.2003.00144.x. PMID 12694354.
Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry. 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.
Merdek KD, Nguyen NT, Toksoz D (2004). "Distinct Activities of the α-Catenin Family, α-Catulin and α-Catenin, on β-Catenin-Mediated Signaling". Mol. Cell. Biol. 24 (6): 2410–22. doi:10.1128/mcb.24.6.2410-2422.2004. PMC 355851 . PMID 14993280.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000119326 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038816 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9806841-5] Zhang JS, Nelson M, Wang L, Liu W, Qian CP, Shridhar V, Urrutia R, Smith DI (Jan 1999). "Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin". Genomics. 54 (1): 149–54. doi:10.1006/geno.1998.5458. PMID 9806841.

[entrez-6] "Entrez Gene: CTNNAL1 catenin (cadherin-associated protein), alpha-like 1".

[pmid12270917-7] Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, Tosolini A, Testa JR, Toksoz D (Nov 2002). "Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation". J. Biol. Chem. 277 (47): 45361–70. doi: 10.1074/jbc.M202447200 . PMID 12270917.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

CTNNAL1

Contents

Interactions

Related Research Articles

References

External links

Further reading