CYM50769

CYM50769

Clinical data
ATC code	none
Identifiers
IUPAC name 5-chloro-2-(9H-fluoren-9-yl)-4-(4-methoxyphenoxy)pyridazin-3-one
CAS Number	1421365-63-0
PubChem CID	50904505
Chemical and physical data
Formula	C24H17ClN2O3
Molar mass	416.86 g·mol−1

CYM50769 is a drug which acts as a selective, non-peptide antagonist at the Neuropeptides B /W receptor NPBW1. It is used for fundamental research into the structure and function of the NPBW1 receptor, and has antidepressant effects in animal studies. ^{[1] [2] [3]}

References

1. Urbano M, Guerrero M, Zhao J, Velaparthi S, Saldanha SA, Chase P, et al. (December 2012). "Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)". Bioorganic & Medicinal Chemistry Letters. 22 (23): 7135–7141. doi:10.1016/j.bmcl.2012.09.074. PMC   3601546 . PMID   23079522.
2. Guerrero M, Urbano M, Schaeffer MT, Brown S, Rosen H, Roberts E (February 2013). "SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists". Bioorganic & Medicinal Chemistry Letters. 23 (3): 614–619. doi:10.1016/j.bmcl.2012.12.030. PMC   3621982 . PMID   23287738.
3. Stein G, Aly JS, Lange L, Manzolillo A, Riege K, Brancato A, et al. (May 2025). "Npbwr1 signaling mediates fast antidepressant action". Molecular Psychiatry. 30 (5): 1828–1835. doi:10.1038/s41380-024-02790-4. PMC   12015170 . PMID   39433904.