Neuropeptide B

Last updated
NPB
Identifiers
Aliases NPB , L7, PPL7, PPneuropeptide B
External IDs OMIM: 607996 MGI: 2387153 HomoloGene: 102151 GeneCards: NPB
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_148896

NM_153288
NM_001347616
NM_001347617

RefSeq (protein)

NP_683694

NP_001334545
NP_001334546
NP_695020

Location (UCSC) Chr 17: 81.9 – 81.9 Mb Chr 11: 120.5 – 120.5 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NBP gene. Neuropeptide B acts via two G protein-coupled receptors, neuropeptide B/W receptors, called NPBW1 and NPBW2 encoded by the genes NPBWR1 and NPBWR2, respectively. Neuropeptide B is thought to be associated with the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. [5] [6] It is expressed throughout the CNS with high levels in the substantia nigra, hypothalamus, hippocampus, and spinal cord.

Related Research Articles

<span class="mw-page-title-main">Galanin receptor 1</span> Protein-coding gene in the species Homo sapiens

Galanin receptor 1 (GAL1) is a G-protein coupled receptor encoded by the GALR1 gene.

<span class="mw-page-title-main">Neuropeptides B/W receptor 1</span> Protein-coding gene in the species Homo sapiens

Neuropeptides B/W receptor 1, also known as NPBW1 and GPR7, is a human protein encoded by the NPBWR1 gene. As implied by its name, it and related gene NPBW2 are transmembranes protein that bind Neuropeptide B (NPB) and Neuropeptide W (NPW), both proteins expressed strongly in parts of the brain that regulate stress and fear including the extended amygdala and stria terminalis. When originally discovered in 1995, these receptors had no known ligands and were called GPR7 and GPR8, but at least three groups in the early 2000s independently identified their endogenous ligands, triggering the name change in 2005.

<span class="mw-page-title-main">Neuropeptides B/W receptor 2</span> Protein-coding gene in the species Homo sapiens

Neuropeptides B/W receptor 2, also known as NPBW2, is a human protein encoded by the NPBWR2 gene.

<span class="mw-page-title-main">GPR12</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.

<span class="mw-page-title-main">GPR27</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 27 is a protein that in humans is encoded by the GPR27 gene.

<span class="mw-page-title-main">Neuropeptide Y receptor Y2</span> Protein-coding gene in the species Homo sapiens

Neuropeptide Y receptor type 2 (Y2R) is a member of the neuropeptide Y receptor family of G-protein coupled receptors, that in humans is encoded by the NPY2R gene.

<span class="mw-page-title-main">Galanin receptor 3</span> Protein-coding gene in the species Homo sapiens

Galanin receptor 3 (GAL3) is a G-protein coupled receptor encoded by the GALR3 gene.

<span class="mw-page-title-main">Neuropeptide FF receptor 2</span> Protein-coding gene in the species Homo sapiens

Neuropeptide FF receptor 2, also known as NPFF2 is a human protein encoded by the NPFFR2 gene.

<span class="mw-page-title-main">Neuropeptide FF receptor 1</span> Protein-coding gene in the species Homo sapiens

Neuropeptide FF receptor 1, also known as NPFF1 is a human protein, encoded by the NPFFR1 gene.

<span class="mw-page-title-main">Pyroglutamylated RFamide peptide receptor</span> Protein-coding gene in the species Homo sapiens

Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G-protein coupled receptor 103 (GPR103) is a protein that in humans is encoded by the QRFPR gene.

<span class="mw-page-title-main">GPR142</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 142 is a protein that in humans is encoded by the GPR142 gene.

<span class="mw-page-title-main">GPRC5D</span> Protein-coding gene in the species Homo sapiens

G-protein coupled receptor family C group 5 member D is a protein that in humans is encoded by the GPRC5D gene.

<span class="mw-page-title-main">OR10W1</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 10W1 is a protein that in humans is encoded by the OR10W1 gene.

<span class="mw-page-title-main">OR52W1</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 52W1 is a protein that in humans is encoded by the OR52W1 gene.

<span class="mw-page-title-main">Neuropeptide FF</span> Protein-coding gene in the species Homo sapiens

NPFF Neuropeptide FF (FLFQPQRFa) is a mammalian amidated neuropeptide originally isolated from bovine brain and characterized as a pain-modulating peptide, with anti-opioid activity on morphine-induced analgesia.

<span class="mw-page-title-main">OR5D14</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 5D14 is a protein that in humans is encoded by the OR5D14 gene.

<span class="mw-page-title-main">OR5D18</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 5D18 is a protein that in humans is encoded by the OR5D18 gene.

<span class="mw-page-title-main">OR2W3</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 2W3 is a protein that in humans is encoded by the OR2W3 gene.

<span class="mw-page-title-main">OR5W2</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 5W2 is a protein that in humans is encoded by the OR5W2 gene.

<span class="mw-page-title-main">NPW</span> Protein-coding gene in the species Homo sapiens

NPW is a gene that in humans encodes Neuropeptide W protein.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183979 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044034 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Singh G, Davenport AP (Aug 2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". British Journal of Pharmacology. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC   1752024 . PMID   16847439.
  6. Hondo M, Ishii M, Sakurai T (2008). "The NPB/NPW Neuropeptide System and Its Role in Regulating Energy Homeostasis, Pain, and Emotion". Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation. Vol. 46. pp. 239–56. doi:10.1007/400_2007_056. ISBN   978-3-540-78350-3. PMID   18204824.