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NPB | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | NPB , L7, PPL7, PPneuropeptide B | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 607996 MGI: 2387153 HomoloGene: 102151 GeneCards: NPB | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NBP gene. Neuropeptide B acts via two G protein-coupled receptors, neuropeptide B/W receptors, called NPBW1 and NPBW2 encoded by the genes NPBWR1 and NPBWR2, respectively. Neuropeptide B is thought to be associated with the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. [5] [6] It is expressed throughout the CNS with high levels in the substantia nigra, hypothalamus, hippocampus, and spinal cord.
Galanin receptor 1 (GAL1) is a G-protein coupled receptor encoded by the GALR1 gene.
Neuropeptides B/W receptor 1, also known as NPBW1 and GPR7, is a human protein encoded by the NPBWR1 gene. As implied by its name, it and related gene NPBW2 are transmembranes protein that bind Neuropeptide B (NPB) and Neuropeptide W (NPW), both proteins expressed strongly in parts of the brain that regulate stress and fear including the extended amygdala and stria terminalis. When originally discovered in 1995, these receptors had no known ligands and were called GPR7 and GPR8, but at least three groups in the early 2000s independently identified their endogenous ligands, triggering the name change in 2005.
Neuropeptides B/W receptor 2, also known as NPBW2, is a human protein encoded by the NPBWR2 gene.
Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.
Probable G-protein coupled receptor 27 is a protein that in humans is encoded by the GPR27 gene.
Neuropeptide Y receptor type 2 (Y2R) is a member of the neuropeptide Y receptor family of G-protein coupled receptors, that in humans is encoded by the NPY2R gene.
Galanin receptor 3 (GAL3) is a G-protein coupled receptor encoded by the GALR3 gene.
Neuropeptide FF receptor 2, also known as NPFF2 is a human protein encoded by the NPFFR2 gene.
Neuropeptide FF receptor 1, also known as NPFF1 is a human protein, encoded by the NPFFR1 gene.
Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G-protein coupled receptor 103 (GPR103) is a protein that in humans is encoded by the QRFPR gene.
Probable G-protein coupled receptor 142 is a protein that in humans is encoded by the GPR142 gene.
G-protein coupled receptor family C group 5 member D is a protein that in humans is encoded by the GPRC5D gene.
Olfactory receptor 10W1 is a protein that in humans is encoded by the OR10W1 gene.
Olfactory receptor 52W1 is a protein that in humans is encoded by the OR52W1 gene.
NPFF Neuropeptide FF (FLFQPQRFa) is a mammalian amidated neuropeptide originally isolated from bovine brain and characterized as a pain-modulating peptide, with anti-opioid activity on morphine-induced analgesia.
Olfactory receptor 5D14 is a protein that in humans is encoded by the OR5D14 gene.
Olfactory receptor 5D18 is a protein that in humans is encoded by the OR5D18 gene.
Olfactory receptor 2W3 is a protein that in humans is encoded by the OR2W3 gene.
Olfactory receptor 5W2 is a protein that in humans is encoded by the OR5W2 gene.
NPW is a gene that in humans encodes Neuropeptide W protein.