Neuropeptide B

NPB
Identifiers
Aliases	NPB , L7, PPL7, PPneuropeptide B
External IDs	OMIM: 607996; MGI: 2387153; HomoloGene: 102151; GeneCards: NPB; OMA:NPB - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q25.3 Start 81,900,745 bp [1] End 81,902,905 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 E2 Start 120,499,303 bp [2] End 120,499,919 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment testicle hypothalamus substantia nigra nucleus accumbens amygdala stromal cell of endometrium Brodmann area 9 putamen anterior cingulate cortex Top expressed in stomach embryo testicle morula embryo right kidney spermatid placenta urinary bladder cerebellar cortex More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding G protein-coupled receptor binding Cellular component extracellular region Biological process neuropeptide signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 256933 208990 Ensembl ENSG00000183979 ENSMUSG00000044034 UniProt Q8NG41 Q8K4P1 RefSeq (mRNA) NM_148896 NM_153288 NM_001347616 NM_001347617 RefSeq (protein) NP_683694 NP_001334545 NP_001334546 NP_695020 Location (UCSC) Chr 17: 81.9 – 81.9 Mb Chr 11: 120.5 – 120.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NBP gene. Neuropeptide B acts via two G protein-coupled receptors, neuropeptide B/W receptors, called NPBW1 and NPBW2 encoded by the genes NPBWR1 and NPBWR2, respectively. Neuropeptide B is thought to be associated with the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. ^{[5] [6]} It is expressed throughout the central nervous system with high levels in the substantia nigra, hypothalamus, hippocampus, and spinal cord.

Function

The functions of neuropeptide B mirror the functions of the closely related neuropeptide W in many respects, as they bind to the same receptor targets but differ mainly in their levels of expression in different tissues, and when and how they are released. However, while neuropeptide W binds to both NPBW1 and NPBW2 with similar affinity, neuropeptide B is relatively selective for NPBW1 and binds only weakly to NPBW2. Central actions of neuropeptide B include regulation of appetite and energy homeostasis, reproductive behavior, pain, anxiety, and emotions. Peripheral actions include regulating secretion of adrenal hormones, and various regulatory roles in pancreatic beta cells and adipose tissue. ^{[7] [8] [9] [10] [11] [12]}

See also

• Neuropeptide FF

References

1. GRCh38: Ensembl release 89: ENSG00000183979 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044034 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Singh G, Davenport AP (Aug 2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". British Journal of Pharmacology. 148 (8): 1033–1041. doi:10.1038/sj.bjp.0706825. PMC   1752024 . PMID   16847439.
6. Hondo M, Ishii M, Sakurai T (2008). "The NPB/NPW Neuropeptide System and Its Role in Regulating Energy Homeostasis, Pain, and Emotion". Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation. Vol. 46. pp. 239–256. doi:10.1007/400_2007_056. ISBN   978-3-540-78350-3. PMID   18204824.
7. Watanabe N, Yamamoto M (2015). "Neural mechanisms of social dominance". Frontiers in Neuroscience. 9: 154. doi: 10.3389/fnins.2015.00154 . PMC   4469834 . PMID   26136644.
8. Chottova Dvorakova M (2018). "Distribution and Function of Neuropeptides W/B Signaling System". Frontiers in Physiology. 9 981. doi: 10.3389/fphys.2018.00981 . PMC   6067035 . PMID   30087623.
9. Wojciechowicz T, Kolodziejski PA, Billert M, Strowski MZ, Nowak KW, Skrzypski M (March 2023). "The Effects of Neuropeptide B on Proliferation and Differentiation of Porcine White Preadipocytes into Mature Adipocytes". International Journal of Molecular Sciences. 24 (7): 6096. doi: 10.3390/ijms24076096 . PMC   10094185 . PMID   37047072.
10. Wojciechowicz T, Billert M, Jasaszwili M, Strowski MZ, Nowak KW, Skrzypski M (June 2021). "The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis". International Journal of Molecular Sciences. 22 (12): 6632. doi: 10.3390/ijms22126632 . PMC   8234850 . PMID   34205710.
11. Watanabe Y, Iwata K, Minabe S, Nakao N, Ishii H, Ozawa H (October 2023). "Central injection of neuropeptide B induces luteinizing hormone release in male and female rats". Peptides. 168 171064. doi:10.1016/j.peptides.2023.171064. PMID   37507090.
12. Stein G, Aly JS, Lange L, Manzolillo A, Riege K, Brancato A, et al. (May 2025). "Npbwr1 signaling mediates fast antidepressant action". Molecular Psychiatry. 30 (5): 1828–1835. doi:10.1038/s41380-024-02790-4. PMC   12015170 . PMID   39433904.

External links

• Uniprot: Neuropeptide B precursor