CYTH2

CYTH2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PBV, 1R8M, 1R8Q, 1R8S, 1S9D, 4JMI, 4JMO, 4JWL, 4JXH, 4L5M, 4Z21 Contents Function ; Interactions ; References ; Further reading ;
Identifiers
Aliases	CYTH2 , ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like, cytohesin 2, cytohesin-2
External IDs	OMIM: 602488 MGI: 1334255 HomoloGene: 32116 GeneCards: CYTH2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,482,314 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,464,005 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; frontal pole; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; Brodmann area 10; ; middle frontal gyrus; ; gallbladder; ; canal of the cervix; ; minor salivary gland; ; skin of abdomen;
	Top expressed in
	ganglionic eminence; ; medial ganglionic eminence; ; neural tube; ; spermatid; ; seminiferous tubule; ; superior frontal gyrus; ; spermatocyte; ; seminal vesicula; ; visual cortex; ; superior surface of tongue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inositol 1,4,5 trisphosphate binding ; protein binding ; guanyl-nucleotide exchange factor activity ; lipid binding ;
Cellular component	cytoplasm ; growth cone ; plasma membrane ; cell projection ; membrane ; Golgi membrane ; cytosol ; adherens junction ; bicellular tight junction ; cell junction ;
Biological process	regulation of ARF protein signal transduction ; endocytosis ; actin cytoskeleton organization ;
	Sources:Amigo / QuickGO
Orthologs
	9266
	19158
	ENSG00000105443
	ENSMUSG00000003269
	Q99418
	P63034
	NM_004228 ; NM_017457
	NM_001112701 ; NM_011181
	NP_004219 ; NP_059431
	NP_001106171 ; NP_035311
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 28, 2024

Cytohesin-2 is a protein that in humans is encoded by the CYTH2 gene.^[5]^[6]^[7]

Function

Cytohesin-2 (CYTH2), formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 2 (PSCD2), is a member of the cytohesin family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. CYTH2 exhibits GEP activity in vitro with ARF1, ARF3, and ARF6. CYTH2 protein is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.^[7]

Interactions

CYTH2 has been shown to interact with Arrestin beta 2 ^[8] and Arrestin beta 1. ^[8]

Related Research Articles

ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosis of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.

G-protein-coupled receptor kinase 2 (GRK2) is an enzyme that in humans is encoded by the ADRBK1 gene. GRK2 was initially called Beta-adrenergic receptor kinase, and is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases that is most highly similar to GRK3(βARK2).

ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.

Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene.

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.

Cytohesin-1 formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a protein that in humans is encoded by the CYTH1 gene.

ADP-ribosylation factor 3 is a protein that in humans is encoded by the ARF3 gene.

Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.

ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene.

ADP-ribosylation factor-like protein 4A is a protein that in humans is encoded by the ARL4A gene.

ADP-ribosylation factor 4 is a protein that in humans is encoded by the ARF4 gene.

ADP-ribosylation factor-like protein 3 is a protein that in humans is encoded by the ARL3 gene.

Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ASAP2 gene.

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.

GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene.

Cytohesin-3 is a protein that in humans is encoded by the CYTH3 gene.

Cytohesin-interacting protein is a protein that in humans is encoded by the CYTIP gene.

IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP₁₀₀ (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa) is a protein that in humans is encoded by the IQSEC1 gene.

Cytohesin-4 is a protein that in humans is encoded by the CYTH4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105443 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003269 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kolanus W, Nagel W, Schiller B, Zeitlmann L, Godar S, Stockinger H, Seed B (Sep 1996). "Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule". Cell. 86 (2): 233–42. doi: 10.1016/S0092-8674(00)80095-1 . PMID 8706128. S2CID 18390795.
↑ Chardin P, Paris S, Antonny B, Robineau S, Béraud-Dufour S, Jackson CL, Chabre M (1996). "A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains". Nature. 384 (6608): 481–4. Bibcode:1996Natur.384..481C. doi:10.1038/384481a0. PMID 8945478. S2CID 4361989.
1 2 "Entrez Gene: PSCD2 pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2)".
1 2 Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ (Nov 2001). "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45): 42509–13. doi: 10.1074/jbc.M108399200 . PMID 11533043.

Meacci E, Tsai SC, Adamik R, Moss J, Vaughan M (1997). "Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor". Proc. Natl. Acad. Sci. U.S.A. 94 (5): 1745–8. Bibcode:1997PNAS...94.1745M. doi: 10.1073/pnas.94.5.1745 . PMC 19987 . PMID 9050849.
Frank S, Upender S, Hansen SH, Casanova JE (1998). "ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6". J. Biol. Chem. 273 (1): 23–7. doi: 10.1074/jbc.273.1.23 . PMID 9417041.
Mossessova E, Gulbis JM, Goldberg J (1998). "Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase". Cell. 92 (3): 415–23. doi: 10.1016/S0092-8674(00)80933-2 . PMID 9476900. S2CID 8093935.
Cherfils J, Ménétrey J, Mathieu M, Le Bras G, Robineau S, Béraud-Dufour S, Antonny B, Chardin P (1998). "Structure of the Sec7 domain of the Arf exchange factor ARNO". Nature. 392 (6671): 101–5. Bibcode:1998Natur.392..101C. doi:10.1038/32210. PMID 9510256. S2CID 4334627.
Venkateswarlu K, Oatey PB, Tavaré JM, Cullen PJ (1998). "Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase". Curr. Biol. 8 (8): 463–6. Bibcode:1998CBio....8..463V. doi: 10.1016/S0960-9822(98)70181-2 . PMID 9550703. S2CID 12974067.
Kim HS (1998). "Assignment of the human cts18.1 gene PSCD2L to chromosome 19 band q13 using a radiation hybrid mapping panel". Cytogenet. Cell Genet. 83 (1–2): 43. doi:10.1159/000015163. PMID 9925920. S2CID 31220052.
Santy LC, Frank SR, Hatfield JC, Casanova JE (1999). "Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch". Curr. Biol. 9 (20): 1173–6. Bibcode:1999CBio....9.1173S. doi: 10.1016/S0960-9822(00)80019-6 . PMID 10531036. S2CID 17664498.
Ogasawara M, Kim SC, Adamik R, Togawa A, Ferrans VJ, Takeda K, Kirby M, Moss J, Vaughan M (2000). "Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors". J. Biol. Chem. 275 (5): 3221–30. doi: 10.1074/jbc.275.5.3221 . PMID 10652308.
Smith JS, Tachibana I, Pohl U, Lee HK, Thanarajasingam U, Portier BP, Ueki K, Ramaswamy S, Billings SJ, Mohrenweiser HW, Louis DN, Jenkins RB (2000). "A transcript map of the chromosome 19q-arm glioma tumor suppressor region". Genomics. 64 (1): 44–50. doi:10.1006/geno.1999.6101. PMID 10708517.
Vitale N, Pacheco-Rodriguez G, Ferrans VJ, Riemenschneider W, Moss J, Vaughan M (2000). "Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1)". J. Biol. Chem. 275 (28): 21331–9. doi: 10.1074/jbc.M909642199 . PMID 10748148.
Macia E, Paris S, Chabre M (2000). "Binding of the PH and polybasic C-terminal domains of ARNO to phosphoinositides and to acidic lipids". Biochemistry. 39 (19): 5893–901. doi:10.1021/bi992795w. PMID 10801341.
Lee SY, Pohajdak B (2000). "N-terminal targeting of guanine nucleotide exchange factors (GEF) for ADP ribosylation factors (ARF) to the Golgi". J. Cell Sci. 113 (11): 1883–9. doi:10.1242/jcs.113.11.1883. PMID 10806099.
Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ (2001). "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45): 42509–13. doi: 10.1074/jbc.M108399200 . PMID 11533043.
Kitano J, Kimura K, Yamazaki Y, Soda T, Shigemoto R, Nakajima Y, Nakanishi S (2002). "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins". J. Neurosci. 22 (4): 1280–9. doi: 10.1523/JNEUROSCI.22-04-01280.2002 . PMC 6757580 . PMID 11850456.
Mansour M, Lee SY, Pohajdak B (2002). "The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP". J. Biol. Chem. 277 (35): 32302–9. doi: 10.1074/jbc.M202898200 . PMID 12052827.
Buchet-Poyau K, Mehenni H, Radhakrishna U, Antonarakis SE (2002). "Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2". Cytogenet. Genome Res. 97 (3–4): 171–8. doi:10.1159/000066620. PMID 12438709. S2CID 36446950.
Huh M, Han JH, Lim CS, Lee SH, Kim S, Kim E, Kaang BK (2003). "Regulation of neuritogenesis and synaptic transmission by msec7-1, a guanine nucleotide exchange factor, in cultured Aplysia neurons". J. Neurochem. 85 (1): 282–5. doi: 10.1046/j.1471-4159.2003.01718.x . PMID 12641750. S2CID 35888745.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105443 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003269 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8706128-5] Kolanus W, Nagel W, Schiller B, Zeitlmann L, Godar S, Stockinger H, Seed B (Sep 1996). "Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule". Cell. 86 (2): 233–42. doi: 10.1016/S0092-8674(00)80095-1 . PMID 8706128. S2CID 18390795.

[pmid8945478-6] Chardin P, Paris S, Antonny B, Robineau S, Béraud-Dufour S, Jackson CL, Chabre M (1996). "A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains". Nature. 384 (6608): 481–4. Bibcode:1996Natur.384..481C. doi:10.1038/384481a0. PMID 8945478. S2CID 4361989.

[entrez-7] 1 2 "Entrez Gene: PSCD2 pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2)".

[pmid11533043-8] 1 2 Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ (Nov 2001). "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". J. Biol. Chem. 276 (45): 42509–13. doi: 10.1074/jbc.M108399200 . PMID 11533043.

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CYTH2

Contents

Function

Interactions

Related Research Articles

References

Further reading