Calbindin 1

CALB1
Identifiers
Aliases	CALB1 , CALB, D-28K, calbindin 1
External IDs	OMIM: 114050 MGI: 88248 HomoloGene: 21026 GeneCards: CALB1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	90,095,475 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	15,908,064 bp
Gene ontology
Molecular function	• calcium ion binding ; • zinc ion binding ; • metal ion binding ; • GO:0001948 protein binding ; • vitamin D binding ; • calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration ; • calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration ;
Cellular component	• cytoplasm ; • cell body ; • synapse ; • intracellular ; • axon ; • terminal bouton ; • neuronal cell body ; • dendrite ; • neuron projection ; • extracellular exosome ; • cell nucleus ; • cytosol ; • dendritic spine ; • calyx of Held ; • hippocampal mossy fiber to CA3 synapse ; • postsynapse ; • glutamatergic synapse ; • GABA-ergic synapse ; • presynaptic cytosol ; • postsynaptic cytosol ; • stereocilium ; • cuticular plate ;
Biological process	• cellular response to organic substance ; • retina layer formation ; • regulation of cytosolic calcium ion concentration ; • calcium ion homeostasis ; • locomotory behavior ; • metanephric distal convoluted tubule development ; • regulation of synaptic plasticity ; • metanephric part of ureteric bud development ; • long-term memory ; • metanephric connecting tubule development ; • retina development in camera-type eye ; • short-term memory ; • learning or memory ; • metanephric collecting duct development ; • cellular protein metabolic process ; • regulation of presynaptic cytosolic calcium ion concentration ; • regulation of long-term synaptic potentiation ; • regulation of postsynaptic cytosolic calcium ion concentration ; • cochlea development ;
	Sources:Amigo / QuickGO
Orthologs
	793
	12307
	ENSG00000104327
	ENSMUSG00000028222
	P05937
	P12658
	NM_004929 ; NM_001366795
	NM_009788
	NP_004920 ; NP_001353724
	NP_033918
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 21, 2020

Calbindin 1 is a protein that in humans is encoded by the CALB1 gene. It belongs to the calbindin family of calcium-binding proteins, along with calretinin (CALB2). ^[5]

Function

The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability.^[6] This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015].

Related Research Articles

Calbindins are three different calcium-binding proteins: calbindin, calretinin and S100G. They were originally described as vitamin D-dependent calcium-binding proteins in the intestine and kidney in the chick and mammals. They are now classified in different subfamilies as they differ in the number of Ca²⁺ binding EF hands.

Hippocalcin is a protein that in humans is encoded by the HPCA gene.

The EF hand is a helix-loop-helix structural domain or motif found in a large family of calcium-binding proteins.

Calcium-binding proteins are proteins that participate in calcium cell signalling pathways by binding to Ca²⁺, the calcium ion that plays an important role in many cellular processes. Calcium-binding proteins have specific domains that bind to calcium and are known to be heterogeneous.

Calretinin, also known as calbindin 2, is a calcium-binding protein involved in calcium signaling. In humans, the calretinin protein is encoded by the CALB2 gene.

Parvalbumin (PV) is a calcium-binding albumin protein with low molecular weight.

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 is a protein that in humans is encoded by the GNG2 gene.

S100 calcium-binding protein P (S100P) is a protein that in humans is encoded by the S100P gene.

Calpain small subunit 1, also known as CAPN4, is a protein that in humans is encoded by the CAPNS1 gene.

Peptidyl-prolyl cis-trans isomerase FKBP1B is an enzyme that in humans is encoded by the FKBP1B gene.

Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene.

Voltage-dependent L-type calcium channel subunit beta-4 is a protein that in humans is encoded by the CACNB4 gene.

Inositol monophosphatase 1 is an enzyme that in humans is encoded by the IMPA1 gene.

S100 calcium-binding protein A3 (S100A3) is a protein that in humans is encoded by the S100A3 gene.

Grancalcin is a protein that in humans is encoded by the GCA gene.

S100 calcium-binding protein G (S100G) is a protein that in humans is encoded by the S100G gene.

C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene.

Secretagogin is a protein that in humans is encoded by the SCGN gene.

S100 calcium binding protein A14 (S100A14) is a protein that in humans is encoded by the S100A14 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000104327 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028222 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Calbindin 1" . Retrieved 2018-10-04.
↑ Noble JW, Almalki R, Roe SM, Wagner A, Duman R, Atack JR (October 2018). "The X-ray structure of human calbindin-D28K: an improved model". Acta Crystallographica Section D. 74 (Pt 10): 1008–1014. doi:10.1107/s2059798318011610. PMC 6173056 . PMID 30289411.

Tao L, Murphy ME, English AM (May 2002). "S-nitrosation of Ca(2+)-loaded and Ca(2+)-free recombinant calbindin D(28K) from human brain". Biochemistry. 41 (19): 6185–92. doi:10.1021/bi015846+. PMID 11994015.
Berggard T, Szczepankiewicz O, Thulin E, Linse S (November 2002). "Myo-inositol monophosphatase is an activated target of calbindin D28k". J. Biol. Chem. 277 (44): 41954–9. doi: 10.1074/jbc.M203492200 . PMID 12176979.
Belkacemi L, Gariépy G, Mounier C, Simoneau L, Lafond J (June 2003). "Expression of calbindin-D28k (CaBP28k) in trophoblasts from human term placenta". Biol. Reprod. 68 (6): 1943–50. doi: 10.1095/biolreprod.102.009373 . PMID 12606474.
Cedervall T, Berggård T, Borek V, Thulin E, Linse S, Akerfeldt KS (January 2005). "Redox sensitive cysteine residues in calbindin D28k are structurally and functionally important". Biochemistry. 44 (2): 684–93. doi:10.1021/bi049232r. PMID 15641794.
Vanbelle C, Halgand F, Cedervall T, Thulin E, Akerfeldt KS, Laprévote O, Linse S (April 2005). "Deamidation and disulfide bridge formation in human calbindin D28k with effects on calcium binding". Protein Sci. 14 (4): 968–79. doi:10.1110/ps.041157705. PMC 2253450 . PMID 15741335.
Valencia I, Legido A, Yelin K, Khurana D, Kothare SV, Katsetos CD (December 2006). "Anomalous inhibitory circuits in cortical tubers of human tuberous sclerosis complex associated with refractory epilepsy: aberrant expression of parvalbumin and calbindin-D28k in dysplastic cortex". J. Child Neurol. 21 (12): 1058–63. doi:10.1177/7010.2006.00242. PMID 17156698. S2CID 36971471.
Vig PJ, Wei J, Shao Q, Hebert MD, Subramony SH, Sutton LT (June 2007). "Role of tissue transglutaminase type 2 in calbindin-D28k interaction with ataxin-1". Neurosci. Lett. 420 (1): 53–7. doi:10.1016/j.neulet.2007.04.005. PMC 1949022 . PMID 17442486.
Zhang C, Sun Y, Wang W, Zhang Y, Ma M, Lou Z (February 2008). "Crystallization and preliminary crystallographic analysis of human Ca 2+-loaded calbindin-D28k". Acta Crystallographica Section F. 64 (Pt 2): 133–6. doi:10.1107/S1744309108001905. PMC 2374171 . PMID 18259068.
Bauer MC, Nilsson H, Thulin E, Frohm B, Malm J, Linse S (April 2008). "Zn2+ binding to human calbindin D(28k) and the role of histidine residues". Protein Sci. 17 (4): 760–7. doi:10.1110/ps.073381108. PMC 2271158 . PMID 18359862.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000104327 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028222 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Calbindin 1" . Retrieved 2018-10-04.

[6] Noble JW, Almalki R, Roe SM, Wagner A, Duman R, Atack JR (October 2018). "The X-ray structure of human calbindin-D28K: an improved model". Acta Crystallographica Section D. 74 (Pt 10): 1008–1014. doi:10.1107/s2059798318011610. PMC 6173056 . PMID 30289411.

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Calbindin 1

Contents

Function

Related Research Articles

References

Further reading