Calumenin

CALU
Identifiers
Aliases	CALU , calumenin
External IDs	OMIM: 603420; MGI: 1097158; HomoloGene: 936; GeneCards: CALU; OMA:CALU - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q32.1 Start 128,739,292 bp [1] End 128,773,400 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 A3.3 Start 29,348,068 bp [2] End 29,377,109 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium smooth muscle tissue tendon of biceps brachii thoracic aorta ascending aorta right coronary artery Achilles tendon Descending thoracic aorta left coronary artery popliteal artery Top expressed in gastrula calvaria dermis efferent ductule molar stroma of bone marrow belly cord body of femur atrium Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding protein binding Cellular component Golgi apparatus endoplasmic reticulum membrane membrane melanosome sarcoplasmic reticulum extracellular region endoplasmic reticulum sarcoplasmic reticulum lumen endoplasmic reticulum lumen Biological process post-translational protein modification biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 813 12321 Ensembl ENSG00000128595 ENSMUSG00000029767 UniProt O43852 O35887 RefSeq (mRNA) NM_001130674 NM_001199671 NM_001199672 NM_001199673 NM_001199674 NM_001219 NM_001285412 NM_007594 NM_184053 RefSeq (protein) NP_001124146 NP_001186600 NP_001186601 NP_001186602 NP_001210 NP_001272341 NP_031620 NP_908942 Location (UCSC) Chr 7: 128.74 – 128.77 Mb Chr 6: 29.35 – 29.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Calumenin is a protein that in humans is encoded by the CALU gene. ^{[5] [6]}

Calumenin (CALU) is a calcium-binding protein localized in the endoplasmic reticulum (ER) and is involved in such ER functions as protein folding and sorting. Calumenin is a member of the EF-hand superfamily in the ER and Golgi apparatus named CERC. CERC is an acronym for its family members Cab-45, reticulocalbin, Erc-55 (RCN2), and calumenin. The CALU gene encodes a deduced 315-amino acid protein containing 6 EF-hand motifs, 1 potential N-glycosylation site, and a C-terminal ER retention signal. The human and mouse CALU proteins are 98% identical. CALU mRNA is ubiquitously expressed in human tissues and maps to 7q32. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000128595 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029767 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yabe D, Taniwaki M, Nakamura T, Kanazawa N, Tashiro K, Honjo T (Aug 1998). "Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32". Genomics. 49 (2): 331–3. doi:10.1006/geno.1998.5245. PMID   9598325.
6. "Entrez Gene: CALU calumenin".

External links

• Human CALU genome location and CALU gene details page in the UCSC Genome Browser .

Further reading

• Yabe D, Nakamura T, Kanazawa N, et al. (1997). "Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF". J. Biol. Chem. 272 (29): 18232–9. doi: 10.1074/jbc.272.29.18232 . PMID   9218460.
• Vorum H, Liu X, Madsen P, et al. (1998). "Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity". Biochim. Biophys. Acta. 1386 (1): 121–31. doi:10.1016/s0167-4838(98)00089-2. PMID   9675259.
• Hseu MJ, Yen CH, Tzeng MC (1999). "Crocalbin: a new calcium-binding protein that is also a binding protein for crotoxin, a neurotoxic phospholipase A2". FEBS Lett. 445 (2–3): 440–4. doi: 10.1016/S0014-5793(99)00177-5 . PMID   10094503. S2CID   40129100.
• Vorum H, Hager H, Christensen BM, et al. (1999). "Human calumenin localizes to the secretory pathway and is secreted to the medium". Exp. Cell Res. 248 (2): 473–81. doi:10.1006/excr.1999.4431. PMID   10222138.
• Vorum H, Jacobsen C, Honoré B (2000). "Calumenin interacts with serum amyloid P component". FEBS Lett. 465 (2–3): 129–34. doi:10.1016/S0014-5793(99)01734-2. PMID   10631319. S2CID   1943508.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Basrur V, Yang F, Kushimoto T, et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. doi:10.1021/pr025562r. PMID   12643545.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID   17081065.