Cantharidic acid

Cantharidic acid

Clinical data
ATC code	none
Identifiers
IUPAC name 2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
CAS Number	28874-45-5
PubChem CID	2544
ChemSpider	2448
ChEBI	CHEBI:78695
ChEMBL	ChEMBL275516
ECHA InfoCard	100.164.462
Chemical and physical data
Formula	C10H14O5
Molar mass	214.217 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1(C2CCC(C1(C)C(=O)O)O2)C(=O)O
InChI InChI=1S/C10H14O5/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14) Key:NMTNUQBORQILRK-UHFFFAOYSA-N

Cantharidic acid is a selective inhibitor of PP2A (protein phosphatase 2) and PP1 (protein phosphatase 1). ^{[1] [2]}

It is the hydrolysis product of cantharidin.

See also

• Endothall

References

1. "Cantharidic Acid | CAS 28874-45-5".
2. Azoulay-Alfaguter I, Strazza M, Peled M, Novak HK, Muller J, Dustin ML, Mor A (August 2017). "The tyrosine phosphatase SHP-1 promotes T cell adhesion by activating the adaptor protein CrkII in the immunological synapse". Science Signaling. 10 (491) eaal2880. doi:10.1126/scisignal.aal2880. PMC   9437928 . PMID   28790195. S2CID   4886031.