Caprin-1

CAPRIN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WBE, 4WBP
Identifiers
Aliases	CAPRIN1 , GPIAP1, GPIP137, GRIP137, M11S1, RNG105, p137GPI, cell cycle associated protein 1
External IDs	OMIM: 601178; MGI: 1858234; HomoloGene: 4310; GeneCards: CAPRIN1; OMA:CAPRIN1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p13 Start 34,051,731 bp [1] End 34,102,610 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E2 Start 103,593,286 bp [2] End 103,627,994 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone Achilles tendon islet of Langerhans endometrium left testis epithelium of colon right testis stromal cell of endometrium gonad Top expressed in genital tubercle tail of embryo ureter primitive streak maxillary prominence abdominal wall external carotid artery internal carotid artery mandibular prominence medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component cytoplasmic stress granule dendrite P-body integral component of plasma membrane cell projection membrane cytoplasm cytosol synapse Biological process cell differentiation negative regulation of translation positive regulation of dendrite morphogenesis positive regulation of dendritic spine morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4076 53872 Ensembl ENSG00000135387 ENSMUSG00000027184 UniProt Q14444 Q60865 RefSeq (mRNA) NM_005898 NM_203364 NM_001111289 NM_001111290 NM_001111291 NM_001111292 NM_016739 RefSeq (protein) NP_005889 NP_976240 NP_001104759 NP_001104760 NP_001104761 NP_001104762 NP_058019 Location (UCSC) Chr 11: 34.05 – 34.1 Mb Chr 2: 103.59 – 103.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Caprin-1 is a protein that in humans is encoded by the CAPRIN1 gene. ^{[5] [6] [7] [8] [9] [10]} It is suggested that Caprin1 (a.k.a. RNG105) is essential for the formation of long-term memory. ^[11]

Clinical significance

In 2022, loss-of-function mutations of the CAPRIN1 gene were shown to result in an autosomal-dominant disorder. Patients having the newly-discovered disorder suffer from language impairment, speech delay, intellectual disability, ADHD and autism spectrum disorder. ^[12] Somatically, they have respiratory problems, limb/skeletal anomalies, developmental delay, feeding difficulties, seizures and ophthalmologic problems.

References

1. GRCh38: Ensembl release 89: ENSG00000135387 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027184 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ellis JA, Luzio JP (September 1995). "Identification and characterization of a novel protein (p137) which transcytoses bidirectionally in Caco-2 cells". The Journal of Biological Chemistry. 270 (35): 20717–20723. doi: 10.1074/jbc.270.35.20717 . PMID   7657653.
6. Wang B, David MD, Schrader JW (October 2005). "Absence of caprin-1 results in defects in cellular proliferation". Journal of Immunology. 175 (7): 4274–4282. doi: 10.4049/jimmunol.175.7.4274 . PMID   16177067.
7. Solomon S, Xu Y, Wang B, David MD, Schubert P, Kennedy D, Schrader JW (March 2007). "Distinct structural features of caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2alpha, entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs". Molecular and Cellular Biology. 27 (6): 2324–42. doi:10.1128/MCB.02300-06. PMC   1820512 . PMID   17210633.
8. Grill B, Wilson GM, Zhang KX, Wang B, Doyonnas R, Quadroni M, Schrader JW (February 2004). "Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins". Journal of Immunology. 172 (4): 2389–2400. doi: 10.4049/jimmunol.172.4.2389 . PMID   14764709.
9. Katsafanas GC, Moss B (December 2004). "Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer". The Journal of Biological Chemistry. 279 (50): 52210–52217. doi: 10.1074/jbc.M411033200 . PMID   15471883.
10. "Entrez Gene: GPIAP1 GPI-anchored membrane protein 1".
11. Nakayama K, Ohashi R, Shinoda Y, Yamazaki M, Abe M, Fujikawa A, et al. (November 2017). "RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation". eLife. 6. doi: 10.7554/eLife.29677 . PMC   5697933 . PMID   29157358.
12. Pavinato L, Delle Vedove A, Carli D, Ferrero M, Carestiato S, Howe JL, Agolini E, Coviello DA, van de Laar I, Au PY, Di Gregorio E, Fabbiani A, Croci S, Mencarelli MA, Bruno LP, Renieri A, Veltra D, Sofocleous C, Faivre L, Mazel B, Safraou H, Denommé-Pichon AS, van Slegtenhorst MA, Giesbertz N, van Jaarsveld RH, Childers A, Rogers RC, Novelli A, De Rubeis S, Buxbaum JD, Scherer SW, Ferrero GB, Wirth B, Brusco A (July 2022). "CAPRIN1 haploinsufficiency causes a neurodevelopmental disorder with language impairment, ADHD and ASD". Brain: A Journal of Neurology. 146 (2): 534–548. doi:10.1093/brain/awac278. PMC   10169411 . PMID   35979925.

Further reading

• Gessler M, Klamt B, Tsaoussidou S, Ellis JA, Luzio JP (February 1996). "The gene encoding the GPI-anchored membrane protein p137GPI (M11S1) maps to human chromosome 11p13 and is highly conserved in the mouse". Genomics. 32 (1): 169–70. doi:10.1006/geno.1996.0099. PMID   8786113.
• de Vries H, Rüegsegger U, Hübner W, Friedlein A, Langen H, Keller W (November 2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors". The EMBO Journal. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMC   305781 . PMID   11060040.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.