Carboxylesterase 2

"CES2" redirects here. For the airport in Quebec, see Saint-Esprit Aerodrome.

CES2
Identifiers
Aliases	CES2 , CE-2, CES2A1, PCE-2, iCE, Carboxylesterase 2, CES-2
External IDs	OMIM: 605278; MGI: 3648740; HomoloGene: 128645; GeneCards: CES2; OMA:CES2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q22.1 Start 66,934,444 bp [1] End 66,945,096 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 D3 Start 105,727,485 bp [2] End 105,747,810 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of ileum mucosa of colon mucosa of sigmoid colon duodenum mucosa of transverse colon mucosa of pharynx rectum right lobe of liver kidney tubule Top expressed in proximal tubule human kidney right kidney duodenum jejunum liver colon testicle islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methylumbelliferyl-acetate deacetylase activity hydrolase activity carboxylic ester hydrolase activity methyl indole-3-acetate esterase activity Cellular component endoplasmic reticulum lumen endoplasmic reticulum extracellular space Biological process xenobiotic metabolic process catabolic process prostaglandin metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8824 436059 Ensembl ENSG00000172831 ENSMUSG00000091813 UniProt O00748 F6Z9B9 RefSeq (mRNA) NM_003869 NM_198061 NM_001365405 NM_001365406 NM_001365407 NM_001365408 NM_001272045 RefSeq (protein) NP_003860 NP_932327 NP_001352334 NP_001352335 NP_001352336 NP_001352337 NP_001258974 Location (UCSC) Chr 16: 66.93 – 66.95 Mb Chr 8: 105.73 – 105.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene. ^{[5] [6] [7]} It is a member of the alpha/beta fold hydrolase family. ^[8]

Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood–brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. ^[7]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Irinotecan Pathway edit]]

Irinotecan Pathway edit

1. The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP229".

References

1. GRCh38: Ensembl release 89: ENSG00000172831 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000091813 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF (June 1997). "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin". The Journal of Biological Chemistry. 272 (23): 14769–14775. doi: 10.1074/jbc.272.23.14769 . PMID   9169443.
6. Schwer H, Langmann T, Daig R, Becker A, Aslanidis C, Schmitz G (April 1997). "Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver". Biochemical and Biophysical Research Communications. 233 (1): 117–120. doi:10.1006/bbrc.1997.6413. PMID   9144407.
7. "Entrez Gene: CES2 carboxylesterase 2 (intestine, liver)".
8. Imai T (June 2006). "Human carboxylesterase isozymes: catalytic properties and rational drug design". Drug Metabolism and Pharmacokinetics. 21 (3): 173–185. doi:10.2133/dmpk.21.173. PMID   16858120.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Yan B, Matoney L, Yang D (September 1999). "Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms". Placenta. 20 (7): 599–607. doi:10.1053/plac.1999.0407. PMID   10452915.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Chagnon P, Michaud J, Mitchell G, Mercier J, Marion JF, Drouin E, et al. (December 2002). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". American Journal of Human Genetics. 71 (6): 1443–1449. doi:10.1086/344580. PMC   378590 . PMID   12417987.
• Saito S, Iida A, Sekine A, Kawauchi S, Higuchi S, Ogawa C, Nakamura Y (2003). "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population". Journal of Human Genetics. 48 (5): 249–270. doi: 10.1007/s10038-003-0021-7 . PMID   12721789.
• Wu MH, Chen P, Remo BF, Cook EH, Das S, Dolan ME (July 2003). "Characterization of multiple promoters in the human carboxylesterase 2 gene". Pharmacogenetics. 13 (7): 425–435. doi:10.1097/00008571-200307000-00008. PMID   12835618.
• Marsh S, Xiao M, Yu J, Ahluwalia R, Minton M, Freimuth RR, et al. (October 2004). "Pharmacogenomic assessment of carboxylesterases 1 and 2". Genomics. 84 (4): 661–668. doi:10.1016/j.ygeno.2004.07.008. PMID   15475243.
• Wu MH, Chen P, Wu X, Liu W, Strom S, Das S, et al. (September 2004). "Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene". Pharmacogenetics. 14 (9): 595–605. doi:10.1097/00008571-200409000-00004. PMID   15475733.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Charasson V, Bellott R, Meynard D, Longy M, Gorry P, Robert J (December 2004). "Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38". Clinical Pharmacology and Therapeutics. 76 (6): 528–535. doi:10.1016/j.clpt.2004.08.007. PMID   15592324. S2CID   23999721.
• Kim SR, Nakamura T, Saito Y, Sai K, Nakajima T, Saito H, et al. (2005). "Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2)". Drug Metabolism and Pharmacokinetics. 18 (5): 327–332. doi:10.2133/dmpk.18.327. PMID   15618752.
• Fox CA, Sapinoso LM, Zhang H, Zhang W, McLeod HL, Petroni GR, et al. (April 2005). "Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas". Neoplasia. 7 (4): 407–416. doi:10.1593/neo.04715. PMC   1501154 . PMID   15967118.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Wang D, Zou L, Jin Q, Hou J, Ge G, Yang L (September 2018). "Human carboxylesterases: a comprehensive review". Acta Pharmaceutica Sinica B. 8 (5): 699–712. doi:10.1016/j.apsb.2018.05.005. PMC   6146386 . PMID   30245959.
• "Tissue expression of CES2 - Summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2022-09-30.