Cathy J. Price

Last updated
Cathy Price

Born
Catherine J. Price
Alma mater Birkbeck College
Scientific career
Fields Cognitive neuroscience
Institutions University College London
Thesis  (1990)
Academic advisors Karl Friston
Notable students Maria Luisa Gorno-Tempini
Website www.fil.ion.ucl.ac.uk/Price/ OOjs UI icon edit-ltr-progressive.svg

Catherine "Cathy" J. Price FRS FMedSci is a Professor of Cognitive Neuroscience and Director of the Wellcome Trust Centre for Neuroimaging at University College London. [1]

Contents

Her overarching research goal is to provide a model of the neural basis of language [2] that predicts and explains speech and language difficulties and their recovery after brain damage (stroke or neurosurgery). [3] She is a world-leading, renowned neuroscientist. [4]

Price is also Director of the Wellcome Centre for Human Neuroimaging. [5]

Education

Price obtained her bachelor's degree in 1984, and her PhD in 1990, both from Birkbeck College. [6]

Professor Kia Nobre, who nominated Price for the 5th Suffrage award for Life Sciences, said: "She blossomed through the trenches of a very macho world with gentle words, generous deeds, scientific commitment and rigour, genuine translation of research to clinical benefit, and humour." [7]

Price originally trained as a neuropsychologist studying reading and object recognition in patients with brain damage. In 1991, she joined the Medical Research Council (MRC) cyclotron unit at the inception of human brain mapping and used PET scanning to provide new insights into the functional anatomy of reading, speech perception, speech production and semantics.

Research and career

In 1995, Price moved to University College London using MRI scanning to show how language abilities and IQ are reflected in brain structure. For example, by combining structural and functional imaging data from healthy participants, Price has shown the remarkable effect that learning has on the structure of the brain. This is illustrated in a series of 3 Nature papers that map structural brain changes associated with (i) learning a second language, [8] (ii) learning to read in adulthood [9] and (iii) naturally occurring changes in verbal and nonverbal IQ in the teenage brain. [10]

Price has made two strong theoretical claims. Contrary to traditional views, her “cognitive ontologies” theory [11] claimed that there are no parts of the human brain that are dedicated to language processing. Instead, specialisation for all types of language processing emerge through cross-talk among unique combinations of areas that are each involved in many other non-linguistic functions. Redefining the functional components of language, in terms of the underlying neural systems would, Price proposes, allow us to generate cognitive models that are both physiologically plausible and clinically useful. [12] Her “cognitive degeneracy” theory [13] claimed that the same language task can be supported by different neural pathways, and that an understanding of when and why different neural pathways are used is essential for understanding how patients recover language after brain damage.

Since 2012, Price has turned her attention to developing a tool for predicting language outcome and recovery after stroke (the PLORAS study). [14] To this end, she is creating a database that provides easy access to multiple sources of information (behaviour, demographics, brain structure and function) from thousands of stroke survivors. Predictions for new patients are based on how others with similar brain damage and demographics were observed to recover from the same symptoms. The same data, and the theory of cognitive degeneracy, can also be used to explain recovery in terms of the degree to which patients have preserved the set of neural pathways needed to produce speech and language (Seghier and Price, 2018). [15]

In March 2020, her h-index is 86 from a total of 322 papers, with more than 24,000 citations. [16]

Awards and honours

Related Research Articles

Cognitive neuroscience Scientific field

Cognitive neuroscience is the scientific field that is concerned with the study of the biological processes and aspects that underlie cognition, with a specific focus on the neural connections in the brain which are involved in mental processes. It addresses the questions of how cognitive activities are affected or controlled by neural circuits in the brain. Cognitive neuroscience is a branch of both neuroscience and psychology, overlapping with disciplines such as behavioral neuroscience, cognitive psychology, physiological psychology and affective neuroscience. Cognitive neuroscience relies upon theories in cognitive science coupled with evidence from neurobiology, and computational modeling.

Cognitive neuropsychology is a branch of cognitive psychology that aims to understand how the structure and function of the brain relates to specific psychological processes. Cognitive psychology is the science that looks at how mental processes are responsible for our cognitive abilities to store and produce new memories, produce language, recognize people and objects, as well as our ability to reason and problem solve. Cognitive neuropsychology places a particular emphasis on studying the cognitive effects of brain injury or neurological illness with a view to inferring models of normal cognitive functioning. Evidence is based on case studies of individual brain damaged patients who show deficits in brain areas and from patients who exhibit double dissociations. Double dissociations involve two patients and two tasks. One patient is impaired at one task but normal on the other, while the other patient is normal on the first task and impaired on the other. For example, patient A would be poor at reading printed words while still being normal at understanding spoken words, while the patient B would be normal at understanding written words and be poor at understanding spoken words. Scientists can interpret this information to explain how there is a single cognitive module for word comprehension. From studies like these, researchers infer that different areas of the brain are highly specialised. Cognitive neuropsychology can be distinguished from cognitive neuroscience, which is also interested in brain damaged patients, but is particularly focused on uncovering the neural mechanisms underlying cognitive processes.

Functional neuroimaging

Functional neuroimaging is the use of neuroimaging technology to measure an aspect of brain function, often with a view to understanding the relationship between activity in certain brain areas and specific mental functions. It is primarily used as a research tool in cognitive neuroscience, cognitive psychology, neuropsychology, and social neuroscience.

Neurophilosophy or philosophy of neuroscience is the interdisciplinary study of neuroscience and philosophy that explores the relevance of neuroscientific studies to the arguments traditionally categorized as philosophy of mind. The philosophy of neuroscience attempts to clarify neuroscientific methods and results using the conceptual rigor and methods of philosophy of science.

Geraint Rees

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Chris Frith

Christopher Donald Frith, is a psychologist and professor emeritus at the Wellcome Trust Centre for Neuroimaging at University College London. Visiting Professor at the Interacting Minds Centre at Aarhus University, Research Fellow at the Institute of Philosophy and Quondam Fellow of All Souls College, Oxford.

In neuropsychology, dissociation involves identifying the neural substrate of a particular brain function through identification of case studies, neuroimaging, or neuropsychological testing.

Wellcome Centre for Human Neuroimaging Laboratory of the University College London

The Wellcome Centre for Human Neuroimaging, formerly the Wellcome Trust Centre for Neuroimaging at University College London is an interdisciplinary centre for neuroimaging research based in London, United Kingdom.

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Jonathon Stevens "Jon Driver" was a psychologist and neuroscientist. He was a leading figure in the study of perception, selective attention and multisensory integration in the normal and damaged human brain.

Neurorehabilitation is a complex medical process which aims to aid recovery from a nervous system injury, and to minimize and/or compensate for any functional alterations resulting from it.

Various aspects of multilingualism have been studied in the field of neurology. These include the representation of different language systems in the brain, the effects of multilingualism on the brain's structural plasticity, aphasia in multilingual individuals, and bimodal bilinguals. Neurological studies of multilingualism are carried out with functional neuroimaging, electrophysiology, and through observation of people who have suffered brain damage.

UCL Queen Square Institute of Neurology Academic institution in United Kingdom

The UCL Queen Square Institute of Neurology is an institute within the Faculty of Brain Sciences of University College London (UCL) and is located in London, United Kingdom. Together with the National Hospital for Neurology and Neurosurgery, an adjacent facility with which it cooperates closely, the institute forms a major centre for teaching, training and research in neurology and allied clinical and basic neurosciences.

Eleanor Maguire Irish neuropsychologist

Eleanor Anne Maguire is an Irish neuroscientist. Since 2007, she has been Professor of Cognitive Neuroscience at University College London where she is also a Wellcome Trust Principal Research Fellow.

The following outline is provided as an overview of and topical guide to brain mapping:

Sophie Scott British neuroscientist

Sophie Kerttu Scott is a British neuroscientist and Wellcome Trust Senior Fellow at University College London (UCL). Her research investigates the cognitive neuroscience of voices, speech and laughter particularly speech perception, speech production, vocal emotions and human communication. She also serves as director of UCL's Institute of Cognitive Neuroscience.

Social cognitive neuroscience is the scientific study of the biological processes underpinning social cognition. Specifically, it uses the tools of neuroscience to study "the mental mechanisms that create, frame, regulate, and respond to our experience of the social world". Social cognitive neuroscience uses the epistemological foundations of cognitive neuroscience, and is closely related to social neuroscience. Social cognitive neuroscience employs human neuroimaging, typically using functional magnetic resonance imaging (fMRI). Human brain stimulation techniques such as transcranial magnetic stimulation and transcranial direct-current stimulation are also used. In nonhuman animals, direct electrophysiological recordings and electrical stimulation of single cells and neuronal populations are utilized for investigating lower-level social cognitive processes.

Rex Eugene Jung is an American psychologist who has researched on the neural basis of human intelligence and creativity. He is an assistant professor at the University of New Mexico, where he is the director of neuropsychological services. Jung is also a practicing psychologist at his private clinic.

Kathryn Emma Watkins is an experimental psychologist in the Wellcome Trust centre for integrative neuroimaging at the University of Oxford and a tutorial fellow at St Anne's College, Oxford. Her research investigates the brain processes that underlie speech, language and development.

Steven L. Small is the Aage and Margareta Møller Distinguished Professor in Behavioral and Brain Sciences at the University of Texas at Dallas, and dean of its School of Behavioral and Brain Sciences. Small is a specialist in the neurobiology of language.  

Heidi Johansen-Berg is a Professor of Cognitive Neuroscience and Director of the Wellcome Centre for Integrative Neuroimaging at the University of Oxford. She studies brain plasticity in the context of stroke rehabilitation and aging.

References

  1. "Professor Cathy Price". Wellcome Trust Centre for Neuroimaging. University College London.
  2. Price CJ (October 2000). "The anatomy of language: contributions from functional neuroimaging". Journal of Anatomy. 197 (3): 335–59. doi:10.1046/j.1469-7580.2000.19730335.x. PMC   1468137 . PMID   11117622.
  3. "UCL Language Research Team". Wellcome Trust. Retrieved 2020-03-19.
  4. "Explaining Language Outcome and Recovery After Stroke (ELORAS)". Wellcome Trust. Retrieved 2020-03-19.
  5. 1 2 "Catherine Price | Royal Society". royalsociety.org. Retrieved 2020-08-16.
  6. "Prof Cathy Price". UCL IRIS.
  7. UCL (2018-06-07). "Leading UCL neuroscientist honoured for brain imaging research". UCL News. Retrieved 2020-08-16.
  8. Mechelli, A.; Crinion, J.; Noppeney, U.; et al. (2004). "Structural plasticity in the bilingual brain". Nature. 431 (7010): 757. doi:10.1038/431757a. hdl: 11858/00-001M-0000-0013-D79B-1 . PMID   15483594. S2CID   4338340.
  9. Carreiras; Seghier, M.; Baquero, S.; et al. (2009). "An anatomical signature for literacy". Nature. 461 (7266): 983–986. Bibcode:2009Natur.461..983C. doi:10.1038/nature08461. PMID   19829380. S2CID   205218359.
  10. Ramsden, S.; Richardson, F.; Josse, G.; et al. (2011). "Verbal and non-verbal intelligence changes in the teenage brain". Nature. 479 (7371): 113–116. Bibcode:2011Natur.479..113R. doi:10.1038/nature10514. PMC   3672949 . PMID   22012265.
  11. Price, Cathy J.; Friston, Karl J. (2005). "Functional ontologies for cognition: The systematic definition of structure and function". Cognitive Neuropsychology. 22 (3–4): 262–275. doi:10.1080/02643290442000095. PMID   21038249. S2CID   1735090.
  12. Price, C.J. (2018). "The evolution of cognitive models: From neuropsychology to neuroimaging and back". Cortex. 107: 37–49. doi:10.1016/j.cortex.2017.12.020. PMC   5924872 . PMID   29373117.
  13. Price, C.J.; Friston, Karl J. (2002). "Degeneracy and cognitive anatomy". Trends in Cognitive Sciences. 6 (10): P416-421. doi:10.1016/S1364-6613(02)01976-9. PMID   12413574. S2CID   12073657.
  14. "Predicting Language Outcome and Recovery After Stroke (PLORAS)". Wellcome Trust. Retrieved 2020-03-19.
  15. Seghier, Mohamed L.; Price, Cathy J. (June 2018). "Interpreting and Utilising Intersubject Variability in Brain Function". Trends in Cognitive Sciences. 22 (6): 517–530. doi: 10.1016/j.tics.2018.03.003 . PMC   5962820 . PMID   29609894.
  16. "Cathy J. Price". Semantic Scholar. Retrieved 2020-03-19.
  17. "Leading female scientists awarded Suffrage Science heirlooms". London Institute of Medical Sciences. 6 June 2018. Retrieved 2020-03-19.
  18. "Explaining Language Outcome and Recovery After Stroke (ELORAS)". Wellcome Trust. Retrieved 2020-03-19.
  19. "Fellow of the Academy of Medical Sciences 2014: Cathy Price". Academy of Medical Sciences. Retrieved 2020-03-19.
  20. "The 21st Jean-Louis Signoret Neuropsychology Prize of the Fondation Ipsen has been awarded to Cathy Price (University College London, London, UK)". 2012-12-03. Retrieved 2020-03-19.
  21. 1 2 "Funded People and Projects - Grant Funding" (xls). Wellcome Trust. Retrieved 2020-03-19.
  22. "Justine & Yves Sergent Fund" . Retrieved 2020-03-19.
  23. "Human Brain Mapping". Wiley Online Library. doi:10.1002/(ISSN)1097-0193 . Retrieved 2020-03-19.
  24. "Early Career Investigator Award 2001: Cathy Price". Organization for Human Brain Mapping.
  25. "Prof. Catherine Price". AcademiaNet. Retrieved 2020-03-19.