Centaurin, alpha 1

Last updated
ADAP1
Protein ADAP1 PDB 3FEH.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases ADAP1 , CENTA1, GCS1L, p42IP4, Centaurin, alpha 1, ArfGAP with dual PH domains 1
External IDs OMIM: 608114 MGI: 2442201 HomoloGene: 55997 GeneCards: ADAP1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006869
NM_001284308
NM_001284309
NM_001284310
NM_001284311

Contents

NM_172723

RefSeq (protein)

NP_001271237
NP_001271238
NP_001271239
NP_001271240
NP_006860

n/a

Location (UCSC) Chr 7: 0.9 – 0.96 Mb Chr 5: 139.26 – 139.31 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Arf-GAP with dual PH domain-containing protein 1 is a protein that in humans is encoded by the ADAP1 gene. [5] [6]

Interactions

Centaurin, alpha 1 has been shown to interact with:

Related Research Articles

<span class="mw-page-title-main">Insulin receptor</span> Mammalian protein found in Homo sapiens

The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis; a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer. Insulin signalling controls access to blood glucose in body cells. When insulin falls, especially in those with high insulin sensitivity, body cells begin only to have access to lipids that do not require transport across the membrane. So, in this way, insulin is the key regulator of fat metabolism as well. Biochemically, the insulin receptor is encoded by a single gene INSR, from which alternate splicing during transcription results in either IR-A or IR-B isoforms. Downstream post-translational events of either isoform result in the formation of a proteolytically cleaved α and β subunit, which upon combination are ultimately capable of homo or hetero-dimerisation to produce the ≈320 kDa disulfide-linked transmembrane insulin receptor.

<span class="mw-page-title-main">Phosphatidylinositol (3,4,5)-trisphosphate</span> Chemical compound

Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3), abbreviated PIP3, is the product of the class I phosphoinositide 3-kinases' (PI 3-kinases) phosphorylation of phosphatidylinositol (4,5)-bisphosphate (PIP2). It is a phospholipid that resides on the plasma membrane.

<span class="mw-page-title-main">P110α</span> Human protein-coding gene

The phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, also called p110α protein, is a class I PI 3-kinase catalytic subunit. The human p110α protein is encoded by the PIK3CA gene.

<span class="mw-page-title-main">Phosphatidylinositol 4,5-bisphosphate</span> Chemical compound

Phosphatidylinositol 4,5-bisphosphate or PtdIns(4,5)P2, also known simply as PIP2 or PI(4,5)P2, is a minor phospholipid component of cell membranes. PtdIns(4,5)P2 is enriched at the plasma membrane where it is a substrate for a number of important signaling proteins. PIP2 also forms lipid clusters that sort proteins.

<span class="mw-page-title-main">Pleckstrin homology domain</span> Protein domain

Pleckstrin homology domain or (PHIP) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.

Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for one or more of the classical, naturally occurring prostanoids viz., prostaglandin D2,, PGE2, PGF2alpha, prostacyclin (PGI2), thromboxane A2 (TXA2), and PGH2. They are named based on the prostanoid to which they preferentially bind and respond, e.g. the receptor responsive to PGI2 at lower concentrations than any other prostanoid is named the Prostacyclin receptor (IP). One exception to this rule is the receptor for thromboxane A2 (TP) which binds and responds to PGH2 and TXA2 equally well.

<span class="mw-page-title-main">Nucleolin</span> Protein

Nucleolin is a protein that in humans is encoded by the NCL gene.

<span class="mw-page-title-main">PRKCI</span> Protein-coding gene in the species Homo sapiens

Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.

<span class="mw-page-title-main">Protein kinase D1</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 gene.

<span class="mw-page-title-main">INPP5D</span> Protein-coding gene in the species Homo sapiens

Src homology 2 (SH2) domain containing inositol polyphosphate 5-phosphatase 1(SHIP1) is an enzyme with phosphatase activity. SHIP1 is structured by multiple domain and is encoded by the INPP5D gene in humans. SHIP1 is expressed predominantly by hematopoietic cells but also, for example, by osteoblasts and endothelial cells. This phosphatase is important for the regulation of cellular activation. Not only catalytic but also adaptor activities of this protein are involved in this process. Its movement from the cytosol to the cytoplasmic membrane, where predominantly performs its function, is mediated by tyrosine phosphorylation of the intracellular chains of cell surface receptors that SHIP1 binds. Insufficient regulation of SHIP1 leads to different pathologies.

<span class="mw-page-title-main">HMGB2</span> Protein-coding gene in the species Homo sapiens

High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene.

<span class="mw-page-title-main">PPP1R14A</span> Protein found in humans

Protein phosphatase 1 regulatory subunit 14A also known as CPI-17 is a protein that in humans is encoded by the PPP1R14A gene.

<span class="mw-page-title-main">RASA3</span> Protein-coding gene in the species Homo sapiens

Ras GTPase-activating protein 3 is an enzyme that in humans is encoded by the RASA3 gene.

<span class="mw-page-title-main">PREX1</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein is a protein that in humans is encoded by the PREX1 gene.

<span class="mw-page-title-main">AP3B2</span> Protein-coding gene in the species Homo sapiens

AP-3 complex subunit beta-2 is a protein that in humans is encoded by the AP3B2 gene.

<span class="mw-page-title-main">CENTA2</span> Protein-coding gene in the species Homo sapiens

Arf-GAP with dual PH domain-containing protein 2 is a protein that in humans is encoded by the ADAP2 gene.

<span class="mw-page-title-main">Casein kinase 1, alpha 1</span> Protein-coding gene in the species Homo sapiens

Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene.

<span class="mw-page-title-main">Phosphoinositide-dependent kinase-1</span> Protein-coding gene in the species Homo sapiens

In the field of biochemistry, PDPK1 refers to the protein 3-phosphoinositide-dependent protein kinase-1, an enzyme which is encoded by the PDPK1 gene in humans. It is implicated in the development and progression of melanomas.

Leonard (Len) R Stephens FRS is a molecular biologist, senior group leader and associate director at the Babraham Institute.

<span class="mw-page-title-main">Ras p21 protein activator 2</span> Protein-coding gene in the species Homo sapiens

RAS p21 protein activator 2 is a protein that in humans is encoded by the RASA2 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000105963 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056413 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Venkateswarlu K, Oatey PB, Tavaré JM, Jackson TR, Cullen PJ (Jun 1999). "Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1". The Biochemical Journal. 340 (2): 359–63. doi:10.1042/0264-6021:3400359. PMC   1220257 . PMID   10333475.
  6. "Entrez Gene: CENTA1 centaurin, alpha 1".
  7. Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1–3): 167–71. doi: 10.1016/s0014-5793(02)02614-5 . PMID   12062430. S2CID   84792445.
  8. Dubois T, Kerai P, Zemlickova E, Howell S, Jackson TR, Venkateswarlu K, Cullen PJ, Theibert AB, Larose L, Roach PJ, Aitken A (Jun 2001). "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins". The Journal of Biological Chemistry. 276 (22): 18757–64. doi: 10.1074/jbc.M010005200 . PMID   11278595.
  9. Dubois T, Zemlickova E, Howell S, Aitken A (Feb 2003). "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin". Biochemical and Biophysical Research Communications. 301 (2): 502–8. doi:10.1016/s0006-291x(02)03010-3. PMID   12565890.
  10. 1 2 3 4 Zemlickova E, Dubois T, Kerai P, Clokie S, Cronshaw AD, Wakefield RI, Johannes FJ, Aitken A (Aug 2003). "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C". Biochemical and Biophysical Research Communications. 307 (3): 459–65. doi:10.1016/s0006-291x(03)01187-2. PMID   12893243.

Further reading