Cerevel Therapeutics

Last updated
Cerevel Therapeutics Holdings, Inc.
Company type Public
Nasdaq:  CERE
Russell 2000 Component
Industry Biopharmaceuticals
Founded2018;6 years ago (2018)
FateAcquired by AbbVie (Pending)
Headquarters
Cambridge, Massachusetts
,
United States
Website cerevel.com

Cerevel Therapeutics Holdings, Inc. is a biotechnology and pharmaceuticals company focused on the development of novel therapies for mental and neurological illnesses. [1] Cerevel was established in October 2018, and is headquartered in Cambridge, Massachusetts. [2]

Contents

The company was formed in a collaboration between pharmaceuticals company Pfizer and private equity firm Bain Capital. [3] [4]

In December 2023, AbbVie, an American pharmaceutical company, announced its intention to acquire Cerevel for US$8.7 billion. [5] [6] [7]

Pipeline

Cerevel uses novel approaches and technologies to develop its own drugs and treatment therapies. Its pipeline contains an array of drugs and therapies treating a range of conditions including Schizophrenia, Parkinson's, Epilepsy, mood disorders, and more. [8]

Notable Cerevel drugs and treatments at varying stages of development include:

Approach to Treatment

Cerevel's tagline mission statement is to "unravel the mysteries of the brain" to treat neurological disease. [14] Scientifically, its approach to therapy development focuses on understanding the wiring of the brain, pursuing novel targets, and addressing specific receptor sub-types. [1]

The company has stated its approach to neurotherapy development can be viewed through three key lenses:

Related Research Articles

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<span class="mw-page-title-main">Traxoprodil</span> Chemical compound

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<span class="mw-page-title-main">Tavapadon</span> Chemical compound

Tavapadon (developmental code names CVL-751, PF-06649751) is a dopamine receptor agonist for the treatment of Parkinson's disease., under development by Cerevel Therapeutics who acquired Tavapadon from Pfizer in 2018. It acts as a selective partial agonist of the dopamine D1 (Ki = 8.54 nM) and D5 receptors. It also shows biased agonism for Gs-coupled signaling. As of July 2021, tavapadon is in phase 3 clinical trials for Parkinson's disease.

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CVL-871 is a dopamine receptor agonist which is under development for the treatment of dementia-related apathy. It was originated by Pfizer and is under development by Cerevel Therapeutics. CVL-871 acts as a selective partial agonist of the dopamine D1 and D5 receptors. It is taken via oral administration. As of April 2022, CVL-871 is in phase 2 clinical trials for dementia-related apathy.

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<span class="mw-page-title-main">Emraclidine</span> Chemical compound

Emraclidine is an investigational antipsychotic for the treatment of both schizophrenia and Alzheimer's disease psychosis developed by Cerevel Therapeutics. As of February 2023, it is in phase II of clinical trial. Emraclidine is a positive allosteric modulator that selectively targets the muscarinic acetylcholine receptor M4 subtype. The M4 receptor subtype is expressed in the striatum of the brain, which plays a key role in regulating acetylcholine and dopamine levels. An imbalance of these neurotransmitters has been linked to psychotic symptoms in schizophrenia. Unlike other muscarinic receptors, M4 receptor subtypes are selectively expressed in the striatum and activation of these receptors has been shown to indirectly regulate dopamine levels without blocking D2/D3 receptors, which may lead to unwanted motor side effects seen in current antipsychotics.

References

  1. 1 2 3 4 5 "The Last Frontier of Medicine". Neurology live. 2023-04-21. Retrieved 2024-01-13.
  2. ↑ Logan, Tim (August 7, 2019). "Pfizer spinoff Cerevel moving into Cambridge Crossing". The Boston Globe. Retrieved 2024-01-13.
  3. ↑ "Bain Capital And Pfizer Create New CNS Company Cerevel Therapeutics". markets.businessinsider.com. 2024-01-12. Retrieved 2024-01-13.
  4. ↑ Brodwin, Erin. "Drug giant Pfizer isn't ready to abandon neuroscience — here's its $150-million 'star cluster' strategy for betting on promising brain drug startups". Business Insider. Retrieved 2024-01-13.
  5. ↑ Constantino, Annika Kim (2023-12-06). "AbbVie to acquire neuroscience drugmaker Cerevel Therapeutics for $8.7 billion". CNBC. Retrieved 2024-01-13.
  6. ↑ Armstrong, Annalee (December 6, 2023). "AbbVie adds to neuroscience portfolio with $8.7B deal to acquire Cerevel". Fierce Biotech. Retrieved January 13, 2024.
  7. ↑ "AbbVie to Acquire Cerevel Therapeutics in Transformative Transaction to Strengthen Neuroscience Pipeline". AbbVie News Center. Retrieved 2024-01-13.
  8. ↑ "EMPOWERing the Next Generation". Psychiatric Times. 2023-09-13. Retrieved 2024-01-13.
  9. ↑ "Cerevel Therapeutics Initiates Phase 3 Program of Tavapadon for the Treatment of Parkinson's Disease – Cerevel Therapeutics". www.cerevel.com. 2020-01-14. Retrieved 2024-01-13.
  10. ↑ "Emraclidine – Cerevel Therapeutics". www.cerevel.com. 2020-01-04. Retrieved 2024-01-13.
  11. ↑ "Cerevel Therapeutics Announces Publication of Phase 2a Study Results in Neurology on Its Most Advanced Investigational Epilepsy Treatment – Cerevel Therapeutics". www.cerevel.com. 2019-04-09. Retrieved 2024-01-13.
  12. ↑ "CVL-871 – Cerevel Therapeutics". www.cerevel.com. 2020-01-02. Retrieved 2024-01-13.
  13. ↑ "CVL-354, a novel, brain penetrant and selective kappa opioid receptor antagonist – Cerevel Therapeutics". www.cerevel.com. 2022-12-01. Retrieved 2024-01-13.
  14. ↑ "EX-99". www.sec.gov. Retrieved 2024-01-13.
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