Psychosis is a condition of the mind or psyche that results in difficulties determining what is real and what is not real. Symptoms may include delusions and hallucinations, among other features. Additional symptoms are incoherent speech and behavior that is inappropriate for a given situation. There may also be sleep problems, social withdrawal, lack of motivation, and difficulties carrying out daily activities. Psychosis can have serious adverse outcomes.
Schizophrenia is a mental disorder characterized by reoccurring episodes of psychosis that are correlated with a general misperception of reality. Other common signs include hallucinations, delusions, disorganized thinking and behavior, social withdrawal, and flat or inappropriate affect. Symptoms develop gradually and typically begin during young adulthood and are never resolved. There is no objective diagnostic test; diagnosis is based on observed behavior, a psychiatric history that includes the person's reported experiences, and reports of others familiar with the person. For a diagnosis of schizophrenia, the described symptoms need to have been present for at least six months or one month. Many people with schizophrenia have other mental disorders, especially substance use disorders, depressive disorders, anxiety disorders, and obsessive–compulsive disorder.
Timothy John Crow is a British psychiatrist and researcher from Oxford. Much of his research is related to the causes of schizophrenia. He also has an interest in neurology and the evolutionary theory. He is the Honorary Director of the Prince of Wales International Centre for Research into Schizophrenia and Depression. He qualified at the Royal London Hospital in 1964 and obtained a PhD at the University of Aberdeen, Scotland, in 1970. He is a fellow of the Royal Colleges of Physicians and Psychiatrists and the Academy of Medical Sciences. Crow was for twenty years Head of the Division of Psychiatry of the Medical Research Council (MRC) Clinical Research Centre at Northwick Park Hospital and then a member of the External Scientific staff of the MRC in Oxford.
Orthomolecular psychiatry is the use of orthomolecular medicine for mental illness. Orthomolecular psychiatry has been rejected by evidence-based medicine and has been called quackery. The approach uses unorthodox forms of individualized testing and diagnosis to attempt to establish an etiology for each patient's specific symptoms, and claims to tailor the treatment accordingly, using a combination of nutrients, dietary changes and medications that are claimed to enhance quality of life and functionality as well as to reduce or eliminate symptoms and the use of xenobiotic drugs. Scientific studies have shown mixed results; although there are some promising results from nutritional psychiatry, some forms of orthomolecular psychiatry are ineffective.
Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders. It is sold under the brand names Nitoman and Xenazine among others. On August 15, 2008, the U.S. Food and Drug Administration approved the use of tetrabenazine to treat chorea associated with Huntington's disease. Although other drugs had been used "off label," tetrabenazine was the first approved treatment for Huntington's disease in the U.S. The compound has been known since the 1950s.
Karl Leonhard was a German psychiatrist who was a student and collaborator of Karl Kleist, who himself stood in the tradition of Carl Wernicke. With Kleist, he created a complex nosology of psychotic illnesses. His work covered psychology, psychotherapy, biological psychiatry and biological psychology. Moreover, he created a classification of nonverbal communication.
Peter McGuffin was a Northern Irish psychiatrist and geneticist from Belfast.
In medicine, a prodrome is an early sign or symptom that often indicates the onset of a disease before more diagnostically specific signs and symptoms develop. More specifically, it refers to the period between the first recognition of a disease's symptom until it reaches its more severe form. It is derived from the Greek word prodromos, meaning "running before". Prodromes may be non-specific symptoms or, in a few instances, may clearly indicate a particular disease, such as the prodromal migraine aura.
Postpartum psychosis (PPP), also known as puerperal psychosis or peripartum psychosis, involves the abrupt onset of psychotic symptoms shortly following childbirth, typically within two weeks of delivery but less than 4 weeks postpartum. PPP is a condition currently represented under "Brief Psychotic Disorder" in the Diagnostic and Statistical Manual of Mental Disorders, Volume V (DSM-V). Symptoms may include delusions, hallucinations, disorganized speech, and/or abnormal motor behavior. Other symptoms frequently associated with PPP include confusion, disorganized thought, severe difficulty sleeping, variations of mood disorders, as well as cognitive features such as consciousness that comes and goes or disorientation.
Professor Helmut Beckmann was a German psychiatrist. He was one of the founders of neurodevelopmental theory of schizophrenia and biologically-based psychiatry in Germany.
Jeffrey Alan Lieberman is an American psychiatrist who specializes in schizophrenia and related psychoses and their associated neuroscience (biology) and pharmacological treatment. He was principal investigator for CATIE, the largest and longest independent study ever funded by the United States National Institute of Mental Health to examine existing pharmacotherapies for schizophrenia. He was president of the American Psychiatric Association from May 2013 to May 2014.
John Charles Cutting is a British psychiatrist specialising in schizophrenia research. He has written a number of books, and articles and reviews in professional journals, on the subjects of psychiatry, clinical psychology, schizophrenia and the functioning of the right cerebral hemisphere of the brain.
Substance-induced psychosis is a form of psychosis that is attributed to substance intoxication. It is a psychosis that results from the effects of chemicals or drugs. Various psychoactive substances have been implicated in causing or worsening psychosis in users.
Childhood schizophrenia is similar in characteristics of schizophrenia that develops at a later age, but has an onset before the age of 13 years, and is more difficult to diagnose. Schizophrenia is characterized by positive symptoms that can include hallucinations, delusions, and disorganized speech; negative symptoms, such as blunted affect and avolition and apathy, and a number of cognitive impairments. Differential diagnosis is problematic since several other neurodevelopmental disorders, including autism spectrum disorder, language disorder, and attention deficit hyperactivity disorder, also have signs and symptoms similar to childhood-onset schizophrenia.
The Kraepelinian dichotomy is the division of the major endogenous psychoses into the disease concepts of dementia praecox, which was reformulated as schizophrenia by Eugen Bleuler by 1908, and manic-depressive psychosis, which has now been reconceived as bipolar disorder. This division was formally introduced in the sixth edition of Emil Kraepelin's psychiatric textbook Psychiatrie. Ein Lehrbuch für Studirende und Aerzte, published in 1899. It has been highly influential on modern psychiatric classification systems, the DSM and ICD, and is reflected in the taxonomic separation of schizophrenia from affective psychosis. However, there is also a diagnosis of schizoaffective disorder to cover cases that seem to show symptoms of both.
Frank James Fish was the first professor of psychiatry at the University of Liverpool, and prior to that a senior lecturer in psychiatry at the University of Edinburgh. His publications helped bring the German tradition of descriptive psychopathology to the attention of English-speaking psychiatrists.
Simple-type schizophrenia is a sub-type of schizophrenia included in the International Classification of Diseases (ICD-10), in which it is classified as a mental and behaviour disorder. It is not included in the current Diagnostic and Statistical Manual of Mental Disorders (DSM-5) or the upcoming ICD-11, effective 1 January 2022. Simple-type schizophrenia is characterized by negative ("deficit") symptoms, such as avolition, apathy, anhedonia, reduced affect display, lack of initiative, lack of motivation, low activity; with absence of hallucinations or delusions of any kind.
Ganesan Venkatasubramanian is an Indian psychiatrist and clinician-scientist who works as a professor of psychiatry at the National Institute of Mental Health and Neurosciences, Bangalore (NIMHANS). His overarching research interest to learn the science that will facilitate a personalized approach to understand and treat severe mental disorders like schizophrenia. Venkatasubramanian is known for his studies in the fields of schizophrenia, transcranial Direct Current Stimulation (tDCS), brain imaging, neuroimmunology, neurometabolism and several other areas of biological psychiatry. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, for his contributions to medical sciences in 2018. He was also one of the collaborating scientists in the NIMHANS-IOB Bioinformatics and Proteomics laboratory of the Institute of Bioinformatics (IOB) in Bangalore and NIMHANS. Besides, he is an adjunct faculty at the Centre for Brain Research (CBR) in Bangalore.
Jacob Sergi Kasanin (1897-1946) was a Russian born, American trained psychiatrist who introduced the term acute schizoaffective psychoses in 1933. He was known as Yasha to those close to him. He was born in Slavgorod, on 11 May 1897, and moved to the United States in 1915. He graduated from the University of Michigan with a Bachelor of Science in 1919, Doctor of Medicine in 1921 and a Master of Science in Public health in 1926.
Peter F. Buckley is an American psychiatrist and university administrator who focuses on the neurobiology and treatment of schizophrenia. He received his medical degree from the University College Dublin School of Medicine in Ireland and joined the Medical College of Georgia in 2000 as chair of the Department of Psychiatry and Health Behavior. During the period of 2010–2017 he served as dean of the college. Then he moved to Virginia Commonwealth University and was appointed dean of the school of medicine in 2017, a role in which he served until 2021. Buckley is senior author of a postgraduate textbook of psychiatry and editor-in-chief of Clinical Schizophrenia & Related Psychoses. He has published more than 500 scientific articles. He has served as chancellor of the University of Tennessee Health Science Center in Memphis, Tennessee since February 1, 2022.
