Coiled-coil domain containing 115

CCDC115
Identifiers
Aliases	CCDC115 , ccp1, CDG2O, coiled-coil domain containing 115
External IDs	OMIM: 613734 MGI: 1916918 HomoloGene: 13015 GeneCards: CCDC115
Gene location (Human)
Chr.	Chromosome 2 (human)
End	130,342,699 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	34,478,753 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; prefrontal cortex; ; Brodmann area 9; ; popliteal artery; ; right coronary artery; ; urethra; ; cingulate gyrus; ; monocyte; ; pons; ; canal of the cervix;
	Top expressed in
	secondary oocyte; ; neural tube; ; upper arm; ; olfactory epithelium; ; morula; ; yolk sac; ; ganglionic eminence; ; bone marrow; ; autopod region; ; mirror;
	More reference expression data
	n/a
Gene ontology
Molecular function	unfolded protein binding ;
Cellular component	membrane ; endosome ; lysosome ; COPI-coated vesicle ; cytoplasmic vesicle ; endoplasmic reticulum-Golgi intermediate compartment ; extrinsic component of endoplasmic reticulum membrane ; vacuolar proton-transporting V-type ATPase complex ; endoplasmic reticulum ;
Biological process	cellular iron ion homeostasis ; lysosomal lumen acidification ; cellular response to increased oxygen levels ; lysosomal protein catabolic process ; vacuolar proton-transporting V-type ATPase complex assembly ;
	Sources:Amigo / QuickGO
Orthologs
	84317
	69668
	ENSG00000136710
	ENSMUSG00000042111
	Q96NT0
	Q8VE99
	NM_032357 ; NM_001321118 ; NM_001321119
	NM_027159
	NP_001308047 ; NP_001308048 ; NP_115733
	NP_081435
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 29, 2023

Coiled-coil domain containing 115 is a protein that in humans is encoded by the CCDC115 gene. ^[5]

Function

The protein encoded by this gene has been observed to localize to the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) and coat protein complex I (COPI) vesicles in some human cells. The encoded protein shares some homology with the yeast V-ATPase assembly factor Vma22p, and the orthologous protein in mouse promotes cell proliferation and suppresses cell death. Defects in this gene are a cause of congenital disorder of glycosylation, type IIo in humans. [provided by RefSeq, Mar 2016].

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136710 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042111 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Coiled-coil domain containing 115" . Retrieved 2017-12-27.

Coiled-coil domain containing 115

Contents

Function

Related Research Articles

References

Further reading