Cyclin dependent kinase like 1

CDKL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AGU
Identifiers
Aliases	CDKL1 , KKIALRE, P42, cyclin dependent kinase like 1
External IDs	OMIM: 603441; MGI: 1918341; HomoloGene: 55805; GeneCards: CDKL1; OMA:CDKL1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	50,416,461 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	69,838,041 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; Achilles tendon; ; canal of the cervix; ; body of uterus; ; ectocervix; ; epithelium of colon; ; muscle layer of sigmoid colon; ; right lobe of thyroid gland; ; left ovary; ; monocyte;
	Top expressed in
	right kidney; ; human kidney; ; lumbar subsegment of spinal cord; ; spermatid; ; spermatocyte; ; dentate gyrus of hippocampal formation granule cell; ; blood; ; visual cortex; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; protein kinase activity ; protein serine/threonine kinase activity ; ATP binding ; kinase activity ; cyclin-dependent protein serine/threonine kinase activity ;
Cellular component	cytoplasm ; extracellular exosome ; nucleus ; nucleoplasm ; intracellular membrane-bounded organelle ; ciliary transition zone ;
Biological process	heart development ; phosphorylation ; regulation of cell cycle ; protein phosphorylation ; regulation of cilium assembly ;
	Sources:Amigo / QuickGO
Orthologs
	8814
	71091
	ENSG00000100490
	ENSMUSG00000020990
	Q00532
	Q8CEQ0
	NM_001282236 ; NM_004196 ; NM_001367064 ; NM_001367065
	NM_183294
	NP_001269165 ; NP_004187 ; NP_001353993 ; NP_001353994
	NP_899117
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 06, 2024

Cyclin dependent kinase like 1 is a protein that in humans is encoded by the CDKL1 gene. ^[5]

Function

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus, and two transcript variants encoding different isoforms have been found for this gene.

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100490 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020990 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Cyclin dependent kinase like 1" . Retrieved 2016-06-07.

Cyclin dependent kinase like 1

Contents

Function

Related Research Articles

References

Further reading