DAP (gene)

DAP
Identifiers
Aliases	DAP , death associated protein
External IDs	OMIM: 600954 MGI: 1918190 HomoloGene: 3235 GeneCards: DAP
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5p15.2 Start 10,679,230 bp [1] End 10,761,234 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 B2 Start 31,224,314 bp [2] End 31,274,341 bp [2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1611	223453
Ensembl	ENSG00000112977	ENSMUSG00000039168
UniProt	P51397	Q91XC8
RefSeq (mRNA)	NM_004394 NM_001291963	NM_146057
RefSeq (protein)	NP_001278892 NP_004385	NP_666169
Location (UCSC)	Chr 5: 10.68 – 10.76 Mb	Chr 15: 31.22 – 31.27 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Death-associated protein 1 is a protein that in humans is encoded by the DAP gene. ^{[5] [6] [7]}

DAP gene encodes a basic, proline-rich, 15-kD protein. Death-associated protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000112977 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039168 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Feb 1996). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics. 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID   8530096.
6. Deiss LP, Feinstein E, Berissi H, Cohen O, Kimchi A (Feb 1995). "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death". Genes Dev. 9 (1): 15–30. doi: 10.1101/gad.9.1.15 . PMID   7828849.
7. "Entrez Gene: DAP death-associated protein".

Further reading

• Levy-Strumpf N, Kimchi A (1999). "Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions". Oncogene. 17 (25): 3331–40. doi: 10.1038/sj.onc.1202588 . PMID   9916995.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Zougman A, Wiśniewski JR (2006). "Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins". J. Proteome Res. 5 (4): 925–34. doi:10.1021/pr050415p. PMID   16602700.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.