DAP (gene)

DAP
Identifiers
Aliases	DAP , death associated protein
External IDs	OMIM: 600954; MGI: 1918190; HomoloGene: 3235; GeneCards: DAP; OMA:DAP - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5p15.2 Start 10,679,230 bp [1] End 10,761,234 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 B2 Start 31,224,460 bp [2] End 31,274,487 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas stromal cell of endometrium islet of Langerhans gallbladder right coronary artery thoracic aorta ascending aorta left adrenal gland right adrenal cortex left adrenal cortex Top expressed in transitional epithelium of urinary bladder calvaria gastrula blood pyloric antrum pancreas islet of Langerhans left lobe of liver ankle body of femur More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 1611 223453 Ensembl ENSG00000112977 ENSMUSG00000039168 UniProt P51397 Q91XC8 RefSeq (mRNA) NM_004394 NM_001291963 NM_146057 RefSeq (protein) NP_001278892 NP_004385 NP_666169 Location (UCSC) Chr 5: 10.68 – 10.76 Mb Chr 15: 31.22 – 31.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Death-associated protein 1 is a protein that in humans is encoded by the DAP gene. ^{[5] [6] [7]}

DAP gene encodes a basic, proline-rich, 15-kD protein. Death-associated protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000112977 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039168 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Feb 1996). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics. 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID   8530096.
6. Deiss LP, Feinstein E, Berissi H, Cohen O, Kimchi A (Feb 1995). "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death". Genes Dev. 9 (1): 15–30. doi: 10.1101/gad.9.1.15 . PMID   7828849.
7. "Entrez Gene: DAP death-associated protein".

Further reading

• Levy-Strumpf N, Kimchi A (1999). "Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions". Oncogene. 17 (25): 3331–40. doi: 10.1038/sj.onc.1202588 . PMID   9916995.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Zougman A, Wiśniewski JR (2006). "Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins". J. Proteome Res. 5 (4): 925–34. doi:10.1021/pr050415p. PMID   16602700.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.