DAZAP2

DAZAP2
Identifiers
Aliases	DAZAP2 , PRTB, DAZ associated protein 2
External IDs	OMIM: 607431 MGI: 1344344 HomoloGene: 8038 GeneCards: DAZAP2
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.13 Start 51,238,724 bp [1] End 51,271,362 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15 F1|15 56.36 cM Start 100,513,230 bp [2] End 100,518,642 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid bronchial epithelial cell endothelial cell monocyte glomerulus blood metanephric glomerulus germinal epithelium parotid gland seminal vesicula Top expressed in blood right lung lobe conjunctival fornix seminal vesicula hair follicle left lung lobe submandibular gland cornea spleen iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding WW domain binding identical protein binding receptor tyrosine kinase binding mitogen-activated protein kinase kinase kinase binding protein serine/threonine kinase activator activity Cellular component cytoplasm nucleus nuclear speck protein-containing complex Biological process positive regulation of protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9802 23994 Ensembl ENSG00000183283 ENSMUSG00000000346 UniProt Q15038 Q9DCP9 RefSeq (mRNA) NM_014764 NM_001136264 NM_001136266 NM_001136267 NM_001136268 NM_001136269 NM_011873 RefSeq (protein) NP_001129736 NP_001129738 NP_001129739 NP_001129740 NP_001129741 NP_055579 NP_036003 Location (UCSC) Chr 12: 51.24 – 51.27 Mb Chr 15: 100.51 – 100.52 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DAZ-associated protein 2 is a protein that in humans is encoded by the DAZAP2 gene. ^{[5] [6] [7]}

Function

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region and is deleted in many azoospermic and severely oligospermic men. It is thought that the Y chromosomal DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. ^[7]

Interactions

DAZAP2 has been shown to interact with DAZ1. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000183283 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000346 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (Aug 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID   10857750.
6. Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi: 10.1093/dnares/1.5.223 . PMID   7584044.
7. "Entrez Gene: DAZAP2 DAZ associated protein 2".
8. Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (May 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID   10857750.

Further reading

• Hamilton MH, Tcherepanova I, Huibregtse JM, McDonnell DP (2001). "Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates". J. Biol. Chem. 276 (28): 26324–31. doi: 10.1074/jbc.M101205200 . PMID   11342538.
• Cohen-Barak O, Yi Z, Hagiwara N, Monzen K, Komuro I, Brilliant MH (2003). "Sox6 regulation of cardiac myocyte development". Nucleic Acids Res. 31 (20): 5941–8. doi:10.1093/nar/gkg807. PMC   219484 . PMID   14530442.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Shi Y, Luo S, Peng J, Huang C, Tan D, Hu W (2004). "The structure, expression and function prediction of DAZAP2, a down-regulated gene in multiple myeloma". Genomics Proteomics Bioinformatics. 2 (1): 47–54. doi:10.1016/s1672-0229(04)02007-8. PMC   5172432 . PMID   15629043.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Shi YW, Shen R, Ren W, Tang LJ, Tan DR, Hu WX (2007). "Molecular features and expression of DAZAP2 in human multiple myeloma". Chin. Med. J. 120 (19): 1659–65. doi: 10.1097/00029330-200710010-00003 . PMID   17935665.