DCAF15

DCAF15
Identifiers
Aliases	DCAF15 , C19orf72, DDB1 and CUL4 associated factor 15
External IDs	MGI: 2684420; HomoloGene: 18182; GeneCards: DCAF15; OMA:DCAF15 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	13,961,449 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	84,831,397 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; left testis; ; right testis; ; spleen; ; right hemisphere of cerebellum; ; apex of heart; ; blood; ; skin of leg; ; skin of abdomen; ; right uterine tube;
	Top expressed in
	otic vesicle; ; spermatocyte; ; seminiferous tubule; ; otic placode; ; saccule; ; spermatid; ; epiblast; ; yolk sac; ; thymus; ; intestinal villus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	Cul4-RING E3 ubiquitin ligase complex ; protein-containing complex ;
Biological process	protein ubiquitination ;
	Sources:Amigo / QuickGO
Orthologs
	90379
	212123
	ENSG00000132017 ; ENSG00000288453
	ENSMUSG00000037103
	Q66K64
	Q6PFH3
	NM_138353
	NM_172502 ; NM_001357322
	NP_612362
	NP_766090 ; NP_001344251
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2025

DDB1 and CUL4 associated factor 15 is a protein that in humans is encoded by the DCAF15 gene.^[5]

DCAF15 forms a complex with CUL4A or CUL4B that has E3 ubiquitin ligase activity and is responsible for the proteasome degradation of certain proteins.^[6]

References

1 2 3 ENSG00000288453 GRCh38: Ensembl release 89: ENSG00000132017, ENSG00000288453 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037103 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: DDB1 and CUL4 associated factor 15".
↑ Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting TC, Xie Y, Williams NS, Nijhawan D (April 2017). "Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15". Science. 356 (6336) eaal3755. doi:10.1126/science.aal3755. PMID 28302793. S2CID 3885214.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000288453 GRCh38: Ensembl release 89: ENSG00000132017, ENSG00000288453 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037103 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: DDB1 and CUL4 associated factor 15".

[pmid28302793-6] Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting TC, Xie Y, Williams NS, Nijhawan D (April 2017). "Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15". Science. 356 (6336) eaal3755. doi:10.1126/science.aal3755. PMID 28302793. S2CID 3885214.

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