DCC1

DSCC1
Identifiers
Aliases	DSCC1 , DCC1, DNA replication and sister chromatid cohesion 1
External IDs	OMIM: 613203; MGI: 1919357; HomoloGene: 5464; GeneCards: DSCC1; OMA:DSCC1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q24.12 Start 119,833,976 bp [1] End 119,855,894 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 D1 Start 54,939,495 bp [2] End 54,953,887 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte gonad parotid gland testicle buccal mucosa cell ventricular zone embryo ganglionic eminence hair follicle tendon of biceps brachii Top expressed in hand ureter otic vesicle primary oocyte endocardial cushion abdominal wall vas deferens medial ganglionic eminence seminiferous tubule spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding single-stranded DNA helicase activity DNA binding DNA clamp loader activity Cellular component nucleoplasm nucleus chromosome, centromeric region chromatin Ctf18 RFC-like complex Biological process maintenance of mitotic sister chromatid cohesion cell cycle DNA replication regulation of DNA replication post-translational protein acetylation positive regulation of DNA-directed DNA polymerase activity mitotic sister chromatid cohesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79075 72107 Ensembl ENSG00000136982 ENSMUSG00000022422 UniProt Q9BVC3 Q14AI0 RefSeq (mRNA) NM_024094 NM_183089 NM_001355594 RefSeq (protein) NP_076999 NP_898912 NP_001342523 Location (UCSC) Chr 8: 119.83 – 119.86 Mb Chr 15: 54.94 – 54.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sister chromatid cohesion protein DCC1 is a protein that in humans is encoded by the DSCC1 gene. ^{[5] [6]}

Interactions

DCC1 has been shown to interact with CHTF18. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000136982 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022422 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". The Journal of Biological Chemistry. 278 (32): 30051–6. doi: 10.1074/jbc.M211591200 . PMID   12766176.
6. "Entrez Gene: DCC1 defective in sister chromatid cohesion homolog 1 (S. cerevisiae)".
7. Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". The Journal of Biological Chemistry. 278 (32): 30051–6. doi: 10.1074/jbc.M211591200 . PMID   12766176.
8. Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. Bibcode:2003PNAS..10010237B. doi: 10.1073/pnas.1434308100 . PMC   193545 . PMID   12930902.

Further reading

• Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry. 277 (43): 40362–7. doi: 10.1074/jbc.M206194200 . PMID   12171929.
• Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. Bibcode:2003PNAS..10010237B. doi: 10.1073/pnas.1434308100 . PMC   193545 . PMID   12930902.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.