CHTF18

CHTF18
Identifiers
Aliases	CHTF18 , C16orf41, C321D2.2, C321D2.3, C321D2.4, CHL12, Ctf18, RUVBL, chromosome transmission fidelity factor 18
External IDs	OMIM: 613201 MGI: 2384887 HomoloGene: 32532 GeneCards: CHTF18
Gene location (Human)
Chr.	Chromosome 16 (human)
End	800,737 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	25,946,393 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; sural nerve; ; ganglionic eminence; ; right uterine tube; ; spleen; ; canal of the cervix; ; appendix; ; stromal cell of endometrium; ; skin of abdomen; ; Brodmann area 9;
	Top expressed in
	yolk sac; ; internal carotid artery; ; external carotid artery; ; morula; ; somite; ; spermatocyte; ; spermatid; ; maxillary prominence; ; thymus; ; seminiferous tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding ; DNA binding ; single-stranded DNA helicase activity ; protein binding ; ATP binding ; DNA clamp loader activity ;
Cellular component	membrane ; Ctf18 RFC-like complex ; nucleus ; nucleoplasm ; cytosol ;
Biological process	DNA replication ; cell cycle ; positive regulation of DNA-directed DNA polymerase activity ;
	Sources:Amigo / QuickGO
Orthologs
	63922
	214901
	ENSG00000127586
	ENSMUSG00000019214
	Q8WVB6
	Q8BIW9
	NM_022092
	NM_145409
	NP_071375
	NP_663384
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 29, 2022

Chromosome transmission fidelity protein 18 homolog is a protein that in humans is encoded by the CHTF18 gene.^[5]^[6]

Interactions

CHTF18 has been shown to interact with:

Related Research Articles

Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin remodeling and epigenetics.

MSH6 or mutS homolog 6 is a gene that codes for DNA mismatch repair protein Msh6 in the budding yeast Saccharomyces cerevisiae. It is the homologue of the human "G/T binding protein," (GTBP) also called p160 or hMSH6. The MSH6 protein is a member of the Mutator S (MutS) family of proteins that are involved in DNA damage repair.

Ku70 is a protein that, in humans, is encoded by the XRCC6 gene.

Cell cycle checkpoint protein RAD17 is a protein that in humans is encoded by the RAD17 gene.

Checkpoint protein HUS1 is a protein that in humans is encoded by the HUS1 gene.

Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene.

Cell cycle checkpoint protein RAD1 is a protein that in humans is encoded by the RAD1 gene.

Replication factor C subunit 1 is a protein that in humans is encoded by the RFC1 gene.

Cyclin-O is a protein that in humans is encoded by the CCNO gene.

Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans.

<span class="mw-page-title-main">MSH3</span> Protein-coding gene in the species Homo sapiens

DNA mismatch repair protein, MutS Homolog 3 (MSH3) is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system. MSH3 typically forms the heterodimer MutSβ with MSH2 in order to correct long insertion/deletion loops and base-base mispairs in microsatellites during DNA synthesis. Deficient capacity for MMR is found in approximately 15% of colorectal cancers, and somatic mutations in the MSH3 gene can be found in nearly 50% of MMR-deficient colorectal cancers.

Replication factor C subunit 4 is a protein that in humans is encoded by the RFC4 gene.

Replication factor C subunit 2 is a protein that in humans is encoded by the RFC2 gene.

Replication factor C subunit 3 is a protein that in humans is encoded by the RFC3 gene.

Replication factor C subunit 5 is a protein that in humans is encoded by the RFC5 gene.

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene. It is a component of the DNA polymerase delta complex.

Sister chromatid cohesion protein DCC1 is a protein that in humans is encoded by the DSCC1 gene.

DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene. It is a component of the DNA polymerase delta complex.

Chromosome transmission fidelity protein 8 homolog is a protein that in humans is encoded by the CHTF8 gene.

Sister chromatid cohesion refers to the process by which sister chromatids are paired and held together during certain phases of the cell cycle. Establishment of sister chromatid cohesion is the process by which chromatin-associated cohesin protein becomes competent to physically bind together the sister chromatids. In general, cohesion is established during S phase as DNA is replicated, and is lost when chromosomes segregate during mitosis and meiosis. Some studies have suggested that cohesion aids in aligning the kinetochores during mitosis by forcing the kinetochores to face opposite cell poles.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000127586 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019214 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry. 277 (43): 40362–7. doi: 10.1074/jbc.M206194200 . PMID 12171929.
↑ "Entrez Gene: CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)".
1 2 3 4 5 Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. Bibcode:2003PNAS..10010237B. doi: 10.1073/pnas.1434308100 . PMC 193545 . PMID 12930902.
1 2 3 Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". The Journal of Biological Chemistry. 278 (32): 30051–6. doi: 10.1074/jbc.M211591200 . PMID 12766176.

External links

Human CHTF18 genome location and CHTF18 gene details page in the UCSC Genome Browser .

Shiomi Y, Masutani C, Hanaoka F, Kimura H, Tsurimoto T (Jul 2007). "A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity". The Journal of Biological Chemistry. 282 (29): 20906–14. doi: 10.1074/jbc.M610102200 . PMID 17545166.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. Bibcode:2003PNAS..10010237B. doi: 10.1073/pnas.1434308100 . PMC 193545 . PMID 12930902.
Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". The Journal of Biological Chemistry. 278 (32): 30051–6. doi: 10.1074/jbc.M211591200 . PMID 12766176.
Naiki T, Kondo T, Nakada D, Matsumoto K, Sugimoto K (Sep 2001). "Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway". Molecular and Cellular Biology. 21 (17): 5838–45. doi:10.1128/MCB.21.17.5838-5845.2001. PMC 87303 . PMID 11486023.
Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (Feb 2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics. 10 (4): 339–52. doi: 10.1093/hmg/10.4.339 . PMID 11157797.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000127586 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019214 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12171929-5] 1 2 Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry. 277 (43): 40362–7. doi: 10.1074/jbc.M206194200 . PMID 12171929.

[entrez-6] "Entrez Gene: CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)".

[pmid12930902-7] 1 2 3 4 5 Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. Bibcode:2003PNAS..10010237B. doi: 10.1073/pnas.1434308100 . PMC 193545 . PMID 12930902.

[pmid12766176-8] 1 2 3 Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". The Journal of Biological Chemistry. 278 (32): 30051–6. doi: 10.1074/jbc.M211591200 . PMID 12766176.

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CHTF18

Contents

Interactions

Related Research Articles

References

External links

Further reading