DCTN5

DCTN5
Identifiers
Aliases	DCTN5 , dynactin subunit 5
External IDs	OMIM: 612962; MGI: 1891689; HomoloGene: 10998; GeneCards: DCTN5; OMA:DCTN5 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p12.2 Start 23,641,466 bp [1] End 23,677,472 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F2 Start 121,732,264 bp [2] End 121,748,267 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans rectum stromal cell of endometrium smooth muscle tissue monocyte mucosa of esophagus ganglionic eminence lymph node epithelium of colon mucosa of transverse colon Top expressed in dentate gyrus of hippocampal formation granule cell right kidney granulocyte superior frontal gyrus medial ganglionic eminence yolk sac pituitary gland tail of embryo cumulus cell blood More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm cytosol centrosome nuclear membrane chromosome, centromeric region cytoskeleton kinetochore nucleoplasm chromosome Biological process endoplasmic reticulum to Golgi vesicle-mediated transport aorta development ventricular septum development antigen processing and presentation of exogenous peptide antigen via MHC class II coronary vasculature development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84516 59288 Ensembl ENSG00000166847 ENSMUSG00000030868 UniProt Q9BTE1 Q9QZB9 RefSeq (mRNA) NM_001199011 NM_001199743 NM_032486 NM_021608 RefSeq (protein) NP_001185940 NP_001186672 NP_115875 NP_067621 Location (UCSC) Chr 16: 23.64 – 23.68 Mb Chr 7: 121.73 – 121.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dynactin 5 (p25) is a protein that in humans is encoded by the DCTN5 gene. ^[5]

This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000166847 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030868 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Dynactin 5 (p25)" . Retrieved 2011-09-20.

Further reading

Eckley DM, Gill SR, Melkonian KA, Bingham JB, Goodson HV, Heuser JE, et al. (October 1999). "Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end". The Journal of Cell Biology. 147 (2): 307–320. doi:10.1083/jcb.147.2.307. PMC   2174220 . PMID   10525537.Parisi G, Fornasari MS, Echave J (March 2004). "Dynactins p25 and p27 are predicted to adopt the LbetaH fold". FEBS Letters. 562 (1–3): 1–4. Bibcode:2004FEBSL.562....1P. doi:10.1016/S0014-5793(04)00165-6. PMID   15043994. S2CID   84381211.Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, et al. (June 2007). "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls". Nature. 447 (7145): 661–678. Bibcode:2007Natur.447..661B. doi:10.1038/nature05911. PMC   2719288 . PMID   17554300.