DDX47

DDX47
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BER
Identifiers
Aliases	DDX47 , E4-DBP, HQ0256, MSTP162, RRP3, DEAD-box helicase 47
External IDs	OMIM: 615428 MGI: 1915005 HomoloGene: 6092 GeneCards: DDX47
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.1 Start 12,813,316 bp [1] End 12,829,981 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 G1 Start 134,988,575 bp [2] End 135,000,739 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans smooth muscle tissue skin of abdomen body of pancreas left lobe of thyroid gland myometrium fallopian tube rectum lymph node left uterine tube Top expressed in Paneth cell primitive streak blastocyst morula renal corpuscle medullary collecting duct yolk sac thymus hair follicle neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding protein binding hydrolase activity ATP binding helicase activity nucleic acid binding RNA binding Cellular component nucleolus membrane nucleus nucleoplasm cytoplasm Biological process mRNA processing extrinsic apoptotic signaling pathway via death domain receptors RNA secondary structure unwinding RNA splicing apoptotic process rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51202 67755 Ensembl ENSG00000213782 ENSMUSG00000030204 UniProt Q9H0S4 Q9CWX9 RefSeq (mRNA) NM_201224 NM_016355 NM_026360 RefSeq (protein) NP_057439 NP_957518 NP_080636 Location (UCSC) Chr 12: 12.81 – 12.83 Mb Chr 6: 134.99 – 135 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable ATP-dependent RNA helicase DDX47 is an enzyme that in humans is encoded by the DDX47 gene. ^[5]

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000213782 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030204 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Doorbar J, Elston RC, Napthine S, et al. (2000). "The E1∧E4 Protein of Human Papillomavirus Type 16 Associates with a Putative RNA Helicase through Sequences in Its C Terminus". J. Virol. 74 (21): 10081–95. doi:10.1128/JVI.74.21.10081-10095.2000. PMC   102047 . PMID   11024137.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC   133617 . PMID   12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Regard JB, Scheek S, Borbiev T, et al. (2004). "Verge: a novel vascular early response gene". J. Neurosci. 24 (16): 4092–103. doi: 10.1523/JNEUROSCI.4252-03.2004 . PMC   6729408 . PMID   15102925.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Lee JH, Rho SB, Chun T (2005). "GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47)". Biotechnol. Lett. 27 (9): 623–8. doi:10.1007/s10529-005-3628-2. PMID   15977068. S2CID   19960329.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.