DEF6

DEF6
Identifiers
Aliases	DEF6 , IBP, SLAT, SWAP70L, guanine nucleotide exchange factor, DEF6 guanine nucleotide exchange factor, IMD87
External IDs	OMIM: 610094; MGI: 1346328; HomoloGene: 11103; GeneCards: DEF6; OMA:DEF6 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.31 Start 35,297,818 bp [1] End 35,321,771 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 A3.3 Start 28,426,752 bp [2] End 28,447,582 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood monocyte spleen lymph node skin of abdomen appendix skin of leg body of pancreas bone marrow Top expressed in thymus granulocyte mesenteric lymph nodes submandibular gland molar lumbar spinal ganglion bone marrow stroma of bone marrow spleen lip More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 50619 23853 Ensembl ENSG00000023892 ENSMUSG00000002257 UniProt Q9H4E7 Q8C2K1 RefSeq (mRNA) NM_022047 NM_027185 RefSeq (protein) NP_071330 NP_081461 Location (UCSC) Chr 6: 35.3 – 35.32 Mb Chr 17: 28.43 – 28.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Differentially expressed in FDCP 6 homolog is a protein that in humans is encoded by the DEF6 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000023892 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002257 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mehta H, Glogauer M, Bécart S, Altman A, Coggeshall KM (May 2009). "Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages". The Journal of Biological Chemistry. 284 (18): 11882–91. doi: 10.1074/jbc.M809712200 . PMC   2673257 . PMID   19251698.
6. "Entrez Gene: DEF6 differentially expressed in FDCP 6 homolog (mouse)".

Further reading

• Oka T, Ihara S, Fukui Y (Jan 2007). "Cooperation of DEF6 with activated Rac in regulating cell morphology". The Journal of Biological Chemistry. 282 (3): 2011–8. doi: 10.1074/jbc.M605153200 . PMID   17121847.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mavrakis KJ, McKinlay KJ, Jones P, Sablitzky F (Apr 2004). "DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA". Experimental Cell Research. 294 (2): 335–44. doi:10.1016/j.yexcr.2003.12.004. PMID   15023524.
• Gupta S, Fanzo JC, Hu C, Cox D, Jang SY, Lee AE, Greenberg S, Pernis AB (Oct 2003). "T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse". The Journal of Biological Chemistry. 278 (44): 43541–9. doi: 10.1074/jbc.M308960200 . PMID   12923183.
• Gupta S, Lee A, Hu C, Fanzo J, Goldberg I, Cattoretti G, Pernis AB (Apr 2003). "Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system". Human Immunology. 64 (4): 389–401. doi:10.1016/S0198-8859(03)00024-7. PMID   12651066.
• Tanaka Y, Bi K, Kitamura R, Hong S, Altman Y, Matsumoto A, Tabata H, Lebedeva S, Bushway PJ, Altman A (Mar 2003). "SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells". Immunity. 18 (3): 403–14. doi: 10.1016/S1074-7613(03)00054-2 . PMID   12648457.