DENND4A

DENND4A
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2PSN, 3B97
Identifiers
Aliases	DENND4A , IRLB, MYCPBP, DENN domain containing 4A
External IDs	OMIM: 600382; MGI: 2142979; HomoloGene: 55933; GeneCards: DENND4A; OMA:DENND4A - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q22.31 Start 65,658,046 bp [1] End 65,792,293 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 C Start 64,718,622 bp [2] End 64,826,949 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon body of pancreas testicle cerebellar hemisphere sural nerve right hemisphere of cerebellum epithelium of colon right lobe of liver islet of Langerhans anterior pituitary Top expressed in granulocyte substantia nigra bone marrow right lobe of liver zygote spleen blood pineal gland piriform cortex otolith organ More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding guanyl-nucleotide exchange factor activity protein binding Cellular component nucleus cytosol Biological process regulation of transcription, DNA-templated transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10260 102442 Ensembl ENSG00000174485 ENSMUSG00000053641 UniProt Q7Z401 n/a RefSeq (mRNA) NM_001144823 NM_005848 NM_001320835 NM_001376919 NM_001376920 NM_001162917 NM_176935 RefSeq (protein) NP_001138295 NP_001307764 NP_005839 NP_001363848 NP_001363849 n/a Location (UCSC) Chr 15: 65.66 – 65.79 Mb Chr 9: 64.72 – 64.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

C-myc promoter-binding protein is a protein that in humans is encoded by the DENND4A gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000174485 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053641 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stasiv YZ, Mashkova TD, Chernov BK, Sokolova IV, Itkes AV, Kisselev LL (Sep 1994). "Cloning of a cDNA encoding a human protein which binds a sequence in the c-myc gene similar to the interferon-stimulated response element". Gene. 145 (2): 267–72. doi:10.1016/0378-1119(94)90018-3. PMID   8056341.
6. Semova N, Kapanadze B, Corcoran M, Kutsenko A, Baranova A, Semov A (Aug 2003). "Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges small star, filled". Genomics. 82 (3): 343–54. doi:10.1016/S0888-7543(03)00103-4. PMID   12906859.
7. "Entrez Gene: DENND4A DENN/MADD domain containing 4A".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" (PDF). Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID   15324660. S2CID   2371325.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Uramoto H, Izumi H, Ise T, et al. (2002). "p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression". J. Biol. Chem. 277 (35): 31694–702. doi: 10.1074/jbc.M200266200 . PMID   12080043.

External links

• DENND4A human gene location in the UCSC Genome Browser .
• DENND4A human gene details in the UCSC Genome Browser .