DENR (gene)

DENR
Identifiers
Aliases	DENR , DRP, DRP1, SMAP-3, density-regulated protein, density regulated re-initiation and release factor
External IDs	OMIM: 604550 MGI: 1915434 HomoloGene: 6275 GeneCards: DENR
Gene location (Human)
Chr.	Chromosome 12 (human)
End	122,771,064 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	124,066,898 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; visceral pleura; ; parietal pleura; ; endothelial cell; ; Brodmann area 23; ; palpebral conjunctiva; ; tibia; ; hair follicle; ; biceps brachii; ; cavity of mouth;
	Top expressed in
	primitive streak; ; somite; ; yolk sac; ; seminal vesicula; ; abdominal wall; ; maxillary prominence; ; supraoptic nucleus; ; superior cervical ganglion; ; lacrimal gland; ; hair follicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; mRNA binding ; translation initiation factor activity ; ribosome binding ; molecular function ;
Cellular component	ribosome ; translation initiation complex ; cellular component ;
Biological process	translational initiation ; ribosome disassembly ; protein biosynthesis ; formation of translation preinitiation complex ; translation reinitiation ; IRES-dependent viral translational initiation ;
	Sources:Amigo / QuickGO
Orthologs
	8562
	68184
	ENSG00000139726
	ENSMUSG00000023106
	O43583
	Q9CQJ6
	NM_003677
	NM_026603
	NP_003668
	NP_080879
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 02, 2023

Density regulated re-initiation and release factor (DENR) is a protein that in humans is encoded by the DENR gene. ^[5]

Function

This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing the HER2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF2 and the initiator Met-tRNA _i^Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008].

Related Research Articles

Ribosome recycling factor or ribosome release factor (RRF) is a protein found in bacterial cells as well as eukaryotic organelles, specifically mitochondria and chloroplasts. It functions to recycle ribosomes after completion of protein synthesis. In humans, the mitochrondrial version is coded by the MRRF gene.

Eukaryotic translation initiation factor 4 gamma 2 is a protein that in humans is encoded by the EIF4G2 gene.

Eukaryotic translation initiation factor 6 (EIF6), also known as Integrin beta 4 binding protein (ITGB4BP), is a human gene.

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene. The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template. Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.

Eukaryotic translation initiation factor 2 subunit 3 (eIF2γ) is a protein that in humans is encoded by the EIF2S3 gene.

Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene.

Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a protein that in humans is encoded by the EIF3D gene.

Eukaryotic translation initiation factor 5B is a protein that in humans is encoded by the EIF5B gene.

<span class="mw-page-title-main">EIF1</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 1 (eIF1) is a protein that in humans is encoded by the EIF1 gene. It is related to yeast SUI1.

Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene.

Eukaryotic translation initiation factor 3, subunit M (eIF3m) also known as PCI domain containing 1 (herpesvirus entry mediator) (PCID1), is a protein that in humans is encoded by the EIF3M gene.

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 is an enzyme that in humans is encoded by the DHX32 gene.

Eukaryotic translation initiation factor 1A, Y-chromosomal is a protein that in humans is encoded by the EIF1AY gene.

<span class="mw-page-title-main">EIF1B</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 1b is a protein that in humans is encoded by the EIF1B gene.

Eukaryotic translation initiation factor 4E family member 3 is a protein that in humans is encoded by the EIF4E3 gene.

ATP-binding cassette sub-family E member 1 (ABCE1) also known as RNase L inhibitor (RLI) is an enzyme that in humans is encoded by the ABCE1 gene.

Mitochondrial ribosomal protein L13 is a protein that in humans is encoded by the MRPL13 gene.

MCTS1, re-initiation and release factor, otherwise known as MCT-1, is a protein that in humans is encoded by the MCTS1 gene.

Eukaryotic translation initiation factor 3 subunit C like is a protein that in humans is encoded by the EIF3CL gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000139726 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023106 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Density regulated re-initiation and release factor" . Retrieved 2018-01-17.

DENR (gene)

Contents

Function

See also

Related Research Articles

References

Further reading