DGKA

DGKA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TUZ
Identifiers
Aliases	DGKA , DAGK, DAGK1, DGK-alpha, diacylglycerol kinase alpha
External IDs	OMIM: 125855 MGI: 102952 HomoloGene: 1028 GeneCards: DGKA
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.2 Start 55,927,319 bp [1] End 55,954,027 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 D3|10 77.14 cM Start 128,556,003 bp [2] End 128,580,724 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen spleen lymph node minor salivary gland thymus rectum appendix jejunal mucosa thymus ascending aorta Top expressed in thymus lymph node corneal stroma blood spleen spermatid colon left colon seminiferous tubule submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding calcium ion binding phospholipid binding ATP binding metal ion binding kinase activity diacylglycerol kinase activity NAD+ kinase activity Cellular component cytosol plasma membrane membrane intracellular anatomical structure Biological process platelet activation protein kinase C-activating G protein-coupled receptor signaling pathway intracellular signal transduction phosphorylation glycerolipid metabolic process phosphatidic acid biosynthetic process diacylglycerol metabolic process lipid phosphorylation metabolism signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1606 13139 Ensembl ENSG00000065357 ENSMUSG00000025357 UniProt P23743 O88673 RefSeq (mRNA) NM_001345 NM_201444 NM_201445 NM_201554 NM_001351033 NM_001351034 NM_001351035 NM_001351036 NM_001351037 NM_001351038 NM_001351039 NM_001351040 NM_016811 NM_001358745 NM_001358746 NM_001372366 NM_001374028 RefSeq (protein) NP_001336 NP_958852 NP_958853 NP_963848 NP_001337962 NP_001337963 NP_001337964 NP_001337965 NP_001337966 NP_001337967 NP_001337968 NP_001337969 NP_058091 NP_001345674 NP_001345675 NP_001359295 NP_001360957 Location (UCSC) Chr 12: 55.93 – 55.95 Mb Chr 10: 128.56 – 128.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Diacylglycerol kinase alpha is an enzyme that in humans is encoded by the DGKA gene. ^{[5] [6] [7]}

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000065357 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025357 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hart TC, Champagne C, Zhou J, Van Dyke TE (Jun 1994). "Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12". Mamm Genome. 5 (2): 123–4. doi:10.1007/BF00292343. PMID   8180475. S2CID   305119.
6. Hart TC, Zhou J, Champagne C, Van Dyke TE, Rao PN, Pettenati MJ (Dec 1994). "Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis". Genomics. 22 (1): 246–7. doi: 10.1006/geno.1994.1376 . PMID   7959783.
7. "Entrez Gene: DGKA diacylglycerol kinase, alpha 80kDa".

Further reading

^[1] *Topham MK, Prescott SM (1999). "Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions". J. Biol. Chem. 274 (17): 11447–50. doi: 10.1074/jbc.274.17.11447 . PMID   10206945.

• Schaap D, de Widt J, van der Wal J, Vandekerckhove J, Van Damme J, Gussow D, Ploegh HL, Van Blitterswijk WJ, Van Der Bend RL (1991). "Purification, cDNA-cloning and expression of human diacylglycerol kinase". FEBS Lett. 275 (1–2): 151–8. doi: 10.1016/0014-5793(90)81461-V . PMID   2175712. S2CID   45452518.
• Flores I, Casaseca T, Martinez-A C, Kanoh H, Merida I (1996). "Phosphatidic acid generation through interleukin 2 (IL-2)-induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation". J. Biol. Chem. 271 (17): 10334–40. doi: 10.1074/jbc.271.17.10334 . PMID   8626603.
• Jones DR, Pettitt TR, Sanjuán MA, Mérida I, Wakelam MJ (1999). "Interleukin-2 causes an increase in saturated/monounsaturated phosphatidic acid derived from 1,2-diacylglycerol and 1-O-alkyl-2-acylglycerol". J. Biol. Chem. 274 (24): 16846–52. doi: 10.1074/jbc.274.24.16846 . PMID   10358029.
• Sanjuán MA, Jones DR, Izquierdo M, Mérida I (2001). "Role of Diacylglycerol Kinase α in the Attenuation of Receptor Signaling". J. Cell Biol. 153 (1): 207–20. doi:10.1083/jcb.153.1.207. PMC   2185527 . PMID   11285286.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Sanjuán MA, Pradet-Balade B, Jones DR, Martínez-a C, Stone JC, Garcia-Sanz JA, Mérida I (2003). "T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation". J. Immunol. 170 (6): 2877–83. doi: 10.4049/jimmunol.170.6.2877 . PMID   12626538.
• Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC   207616 . PMID   14559993.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gronert K, Kantarci A, Levy BD, Clish CB, Odparlik S, Hasturk H, Badwey JA, Colgan SP, Van Dyke TE (2004). "A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage". J. Immunol. 172 (3): 1856–61. doi:10.4049/jimmunol.172.3.1856. PMC   4318492 . PMID   14734770.
• Verrier E, Wang L, Wadham C, Albanese N, Hahn C, Gamble JR, Chatterjee VK, Vadas MA, Xia P (2004). "PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase". Circ. Res. 94 (11): 1515–22. doi:10.1161/01.RES.0000130527.92537.06. PMID   15117825. S2CID   25057646.
• Baldanzi G, Mitola S, Cutrupi S, Filigheddu N, Van Blitterswijk WJ, Sinigaglia F, Bussolino F, Graziani A (2004). "Activation of diacylglycerol kinase alpha is required for VEGF-induced angiogenic signaling in vitro". Oncogene. 23 (28): 4828–38. doi: 10.1038/sj.onc.1207633 . hdl: 11379/21460 . PMID   15122338.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Alonso R, Rodríguez MC, Pindado J, Merino E, Mérida I, Izquierdo M (2005). "Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes". J. Biol. Chem. 280 (31): 28439–50. doi: 10.1074/jbc.M501112200 . PMID   15870081.
• Bacchiocchi R, Baldanzi G, Carbonari D, Capomagi C, Colombo E, Van Blitterswijk WJ, Graziani A, Fazioli F (2005). "Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase". Blood. 106 (6): 2175–82. doi: 10.1182/blood-2005-01-0316 . PMID   15928040.
• Yanagisawa K, Yasuda S, Kai M, Imai S, Yamada K, Yamashita T, Jimbow K, Kanoh H, Sakane F (2007). "Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation". Biochim. Biophys. Acta. 1771 (4): 462–74. doi:10.1016/j.bbalip.2006.12.008. PMID   17276726.

External links

• DAG-kinase catalytic (DAGKc) domain in PROSITE

1. Kovalenko A, Sanin A, Kosmas K, Zhang L, Wang J, Giannikou K, Probst CK, Hougard TR, Rue RW, Krymskaya VP, Asara JM, Lam HC, Kwiatkowski DJ, Henske EP, Filippakis H (2021). "Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex". Cancer Research. 81 (8): 2086–2100. doi:10.1158/0008-5472.CAN-20-2218. PMC   8137542 . PMID   33593821.