DGKG

DGKG
Identifiers
Aliases	DGKG , DAGK3, DGK-GAMMA, diacylglycerol kinase gamma
External IDs	OMIM: 601854 MGI: 105060 HomoloGene: 1029 GeneCards: DGKG
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q27.2-q27.3 Start 186,105,668 bp [1] End 186,362,234 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16 B1|16 13.37 cM Start 22,287,211 bp [2] End 22,475,971 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar cortex cerebellar hemisphere gastric mucosa monocyte cingulate gyrus left ventricle anterior pituitary right lung postcentral gyrus popliteal artery Top expressed in subiculum hippocampus proper cerebellar vermis piriform cortex pontine nuclei ventromedial nucleus arcuate nucleus paraventricular nucleus of hypothalamus superior frontal gyrus parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding calcium ion binding ATP binding metal ion binding kinase activity diacylglycerol kinase activity NAD+ kinase activity Cellular component cytoplasm plasma membrane membrane Biological process platelet activation protein kinase C-activating G protein-coupled receptor signaling pathway intracellular signal transduction neuron development phosphorylation glycerolipid metabolic process lipid phosphorylation metabolism signal transduction diacylglycerol metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1608 110197 Ensembl ENSG00000058866 ENSMUSG00000022861 UniProt P49619 Q91WG7 RefSeq (mRNA) NM_001346 NM_001080744 NM_001080745 NM_138650 NM_001346673 RefSeq (protein) NP_001074213 NP_001074214 NP_001337 NP_001333602 NP_619591 Location (UCSC) Chr 3: 186.11 – 186.36 Mb Chr 16: 22.29 – 22.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Diacylglycerol kinase gamma is an enzyme that in humans is encoded by the DGKG gene. ^{[5] [6]}

This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000058866 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022861 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kai M, Sakane F, Imai S, Wada I, Kanoh H (Aug 1994). "Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells". J Biol Chem. 269 (28): 18492–8. doi: 10.1016/S0021-9258(17)32336-0 . PMID   8034597.
6. "Entrez Gene: DGKG diacylglycerol kinase, gamma 90kDa".

Further reading

• Brose N, Betz A, Wegmeyer H (2004). "Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals". Curr. Opin. Neurobiol. 14 (3): 328–40. doi:10.1016/j.conb.2004.05.006. PMID   15194113. S2CID   7070625.
• Luo B, Regier DS, Prescott SM, Topham MK (2005). "Diacylglycerol kinases". Cell. Signal. 16 (9): 983–9. doi:10.1016/j.cellsig.2004.03.016. PMID   15212759.
• Topham MK (2006). "Signaling roles of diacylglycerol kinases". J. Cell. Biochem. 97 (3): 474–84. doi: 10.1002/jcb.20704 . PMID   16288460. S2CID   38850368.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Yamada K, Sakane F, Matsushima N, Kanoh H (1997). "EF-hand motifs of alpha, beta and gamma isoforms of diacylglycerol kinase bind calcium with different affinities and conformational changes". Biochem. J. 321. ( Pt 1) (Pt 1): 59–64. doi:10.1042/bj3210059. PMC   1218036 . PMID   9003401.
• Stöhr H, Klein J, Gehrig A, et al. (1999). "Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1)". Hum. Genet. 104 (1): 99–105. doi:10.1007/s004390050917. PMID   10071200. S2CID   19248400.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yamada K, Sakane F, Imai S, et al. (2003). "Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cells". Biochem. Biophys. Res. Commun. 305 (1): 101–7. doi:10.1016/S0006-291X(03)00713-7. PMID   12732202.
• Oyaizu K, Kantarci A, Maeda H, et al. (2003). "Identification of mRNAs for the various diacylglycerol kinase isoforms in neutrophils from patients with localized aggressive periodontitis". J. Periodont. Res. 38 (5): 488–95. doi:10.1034/j.1600-0765.2003.00680.x. PMID   12941073.
• Tsushima S, Kai M, Yamada K, et al. (2004). "Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation". J. Biol. Chem. 279 (27): 28603–13. doi: 10.1074/jbc.M314031200 . PMID   15102830.
• Filosto M, Mancuso M, Tomelleri G, et al. (2004). "Hepato-cerebral syndrome: genetic and pathological studies in an infant with a dGK mutation". Acta Neuropathol. 108 (2): 168–71. doi:10.1007/s00401-004-0872-9. PMID   15150663. S2CID   31732164.
• Batista EL, Warbington M, Badwey JA, Van Dyke TE (2005). "Differentiation of HL-60 cells to granulocytes involves regulation of select diacylglycerol kinases (DGKs)". J. Cell. Biochem. 94 (4): 774–93. doi:10.1002/jcb.20356. PMID   15578578. S2CID   114877.
• Matsubara T, Shirai Y, Miyasaka K, et al. (2006). "Nuclear transportation of diacylglycerol kinase gamma and its possible function in the nucleus". J. Biol. Chem. 281 (10): 6152–64. doi: 10.1074/jbc.M509873200 . PMID   16407189.
• Yamaguchi Y, Shirai Y, Matsubara T, et al. (2006). "Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma". J. Biol. Chem. 281 (42): 31627–37. doi: 10.1074/jbc.M606992200 . hdl: 20.500.14094/D2003002 . PMID   16905533.