DHRS1

DHRS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QQ5
Identifiers
Aliases	DHRS1 , SDR19C1, dehydrogenase/reductase (SDR family) member 1, dehydrogenase/reductase 1
External IDs	OMIM: 610410 MGI: 1196314 HomoloGene: 41696 GeneCards: DHRS1
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q12 Start 24,290,598 bp [1] End 24,299,780 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 C3|14 28.19 cM Start 55,739,020 bp [2] End 55,745,690 bp [2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	115817	52585
Ensembl	ENSG00000157379 ENSG00000284868	ENSMUSG00000002332
UniProt	Q96LJ7	Q99L04
RefSeq (mRNA)	NM_001136050 NM_138452	NM_026819
RefSeq (protein)	NP_001129522 NP_612461	NP_081095
Location (UCSC)	Chr 14: 24.29 – 24.3 Mb	Chr 14: 55.74 – 55.75 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Dehydrogenase/reductase SDR family member 1, also known as Short chain dehydrogenase/reductase family 19C member 1 is an enzyme that in humans is encoded by the DHRS1 gene located on chromosome 14. ^{[5] [6] [7]}

Structure

The DHRS1 gene is located on the chromosome 14q21.3 region and contains 9 exons. It encodes a 314-amino-acid, 33-kDa protein that is thought to be located to the endoplasmic reticulum and the mitochondrial inner membrane inside the cell.

Function

The DHRS1 protein is thought to have oxidoreductase activity based on sequence similarity and conserved catalytic sites with other short-chain oxidoreductase enzymes. The enzyme is found to be expressed in the fetal brain. ^[8]

Interactions

The DHRS1 protein is thought to interact with the protein phospholipid scrambase 1 (PLSCR1). ^[9]

References

1. ENSG00000284868 GRCh38: Ensembl release 89: ENSG00000157379, ENSG00000284868 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002332 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wu Q, Xu M, Cheng C, Zhou Z, Huang Y, Zhao W, Zeng L, Xu J, Fu X, Ying K, Xie Y, Mao Y (Aug 2002). "Molecular cloning and characterization of a novel Dehydrogenase/reductase (SDR family) member 1 genea from human fetal brain". Mol Biol Rep. 28 (4): 193–8. doi:10.1023/A:1015722001960. PMID   12153138. S2CID   29552121.
6. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC   2896744 . PMID   19027726.
7. "Entrez Gene: DHRS1 dehydrogenase/reductase (SDR family) member 1".
8. Wu Q, Xu M, Cheng C, Zhou Z, Huang Y, Zhao W, Zeng L, Xu J, Fu X, Ying K, Xie Y, Mao Y (2001). "Molecular cloning and characterization of a novel Dehydrogenase/reductase (SDR family) member 1 genea from human fetal brain". Mol. Biol. Rep. 28 (4): 193–8. doi:10.1023/A:1015722001960. PMID   12153138. S2CID   29552121.
9. http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q96LJ7*

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.