DHX32

DHX32
Identifiers
Aliases	DHX32 , DDX32, DHLP1, DEAH-box helicase 32 (putative)
External IDs	OMIM: 607960 MGI: 2141813 HomoloGene: 56798 GeneCards: DHX32
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q26.2 Start 125,836,337 bp [1] End 125,896,436 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F3 Start 133,322,671 bp [2] End 133,384,455 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland cardia amniotic fluid external globus pallidus olfactory bulb rectum body of tongue pancreatic ductal cell secondary oocyte sperm Top expressed in saccule left colon otic placode pyloric antrum islet of Langerhans Paneth cell Epithelium of stomach soleus muscle myocardium of ventricle secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding ATP binding hydrolase activity helicase activity RNA binding 3'-5' RNA helicase activity Cellular component spliceosomal complex mitochondrion nucleus cytoplasm Biological process mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55760 101437 Ensembl ENSG00000089876 ENSMUSG00000030986 UniProt Q7L7V1 Q8BZS9 RefSeq (mRNA) NM_018180 NM_001286030 NM_001286031 NM_001286032 NM_133941 NM_001357685 RefSeq (protein) NP_060650 NP_001272959 NP_001272960 NP_001272961 NP_598702 NP_001344614 NP_001390352 NP_001390353 NP_001390354 Location (UCSC) Chr 10: 125.84 – 125.9 Mb Chr 7: 133.32 – 133.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 is an enzyme that in humans is encoded by the DHX32 gene. ^[5]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates two transcript variants, but the full length nature of one of the variants has not been defined. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000089876 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030986 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32".

Further reading

• Alli Z, Chen Y, Abdul Wajid S, et al. (2007). "A role for DHX32 in regulating T-cell apoptosis". Anticancer Res. 27 (1A): 373–7. PMID   17352256.
• Chen Y, Alli Z, Ackerley C, et al. (2007). "Altered distribution of heat shock protein 60 (Hsp60) with dysregulated expression of DHX32". Exp. Mol. Pathol. 82 (3): 256–61. doi:10.1016/j.yexmp.2006.11.002. PMID   17174952.
• Alli Z, Ackerley C, Chen Y, et al. (2007). "Nuclear and mitochondrial localization of the putative RNA helicase DHX32". Exp. Mol. Pathol. 81 (3): 245–8. doi:10.1016/j.yexmp.2006.07.005. PMID   16959245.
• Alli Z, Nam EH, Beimnet K, Abdelhaleem M (2006). "The activation-induced expression of DHX32 in Jurkat T cells is specific and involves calcium and nuclear factor of activated T cells". Cell. Immunol. 237 (2): 141–6. doi:10.1016/j.cellimm.2005.12.003. PMID   16414036.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Abdelhaleem M (2002). "The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia". Leuk. Res. 26 (10): 945–54. doi:10.1016/S0145-2126(02)00040-1. PMID   12163057.
• Liu J, Yuan Y, Huan J, Shen Z (2001). "Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2". Oncogene. 20 (3): 336–45. doi: 10.1038/sj.onc.1204098 . PMID   11313963.