DHX34

DHX34
Identifiers
Aliases	DHX34 , DDX34, HRH1, DEAH-box helicase 34, DExH-box helicase 34
External IDs	OMIM: 615475 MGI: 1918973 HomoloGene: 69171 GeneCards: DHX34
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.32 Start 47,349,315 bp [1] End 47,382,704 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A2 Start 15,931,072 bp [2] End 15,955,962 bp [2]
RNA expression pattern Bgee Top expressed in blood testicle spleen Right lobe of liver More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding hydrolase activity ATP binding GO:0008026 helicase activity RNA binding GO:0034459 3'-5' RNA helicase activity Cellular component membrane cytoplasm Biological process nuclear-transcribed mRNA catabolic process RNA processing negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9704	71723
Ensembl	ENSG00000134815	ENSMUSG00000006019
UniProt	Q14147	Q9DBV3
RefSeq (mRNA)	NM_014681 NM_194428	NM_001285931 NM_001285932 NM_027883
RefSeq (protein)	NP_055496	NP_001272860 NP_001272861 NP_082159
Location (UCSC)	Chr 19: 47.35 – 47.38 Mb	Chr 7: 15.93 – 15.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

DExH-box helicase 34 is a protein that in humans is encoded by the DHX34 gene. ^[5]

Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008].

References

1. GRCh38: Ensembl release 89: ENSG00000134815 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006019 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: DExH-box helicase 34" . Retrieved 2018-03-21.

Further reading

• Longman D, Hug N, Keith M, Anastasaki C, Patton EE, Grimes G, Cáceres JF (September 2013). "DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans". Nucleic Acids Res. 41 (17): 8319–31. doi:10.1093/nar/gkt585. PMC   3783168 . PMID   23828042.
• Hug N, Cáceres JF (September 2014). "The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex". Cell Rep. 8 (6): 1845–1856. doi:10.1016/j.celrep.2014.08.020. PMC   4534575 . PMID   25220460.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.