DOC2A

DOC2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4MJJ
Identifiers
Aliases	DOC2A , Doc2, double C2 domain alpha
External IDs	OMIM: 604567; MGI: 109446; HomoloGene: 2657; GeneCards: DOC2A; OMA:DOC2A - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p11.2 Start 30,005,514 bp [1] End 30,023,270 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F3 Start 126,446,588 bp [2] End 126,451,877 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe right hemisphere of cerebellum Brodmann area 9 left testis right testis anterior cingulate cortex prefrontal cortex right uterine tube amygdala mucosa of transverse colon Top expressed in ventromedial nucleus cingulate gyrus primary motor cortex motor neuron lumbar subsegment of spinal cord anterior amygdaloid area piriform cortex barrel cortex prefrontal cortex paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium-dependent phospholipid binding clathrin binding calcium ion binding syntaxin binding protein binding Cellular component neuron projection lysosome synapse synaptic vesicle membrane membrane cytoplasmic vesicle plasma membrane nucleus nucleolus cell junction exocytic vesicle extrinsic component of synaptic vesicle membrane Biological process nervous system development regulation of calcium ion-dependent exocytosis synaptic vesicle exocytosis exocytosis chemical synaptic transmission calcium ion-regulated exocytosis of neurotransmitter vesicle fusion spontaneous neurotransmitter secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8448 13446 Ensembl ENSG00000149927 ENSMUSG00000052301 UniProt Q14183 Q7TNF0 RefSeq (mRNA) NM_001282062 NM_001282063 NM_001282068 NM_003586 NM_010069 NM_001368355 NM_001368356 NM_001368357 NM_001368358 RefSeq (protein) NP_001268991 NP_001268992 NP_001268997 NP_003577 NP_034199 NP_001355284 NP_001355285 NP_001355286 NP_001355287 Location (UCSC) Chr 16: 30.01 – 30.02 Mb Chr 7: 126.45 – 126.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene. ^{[5] [6] [7]}

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. ^[7]

Interactions

DOC2A has been shown to interact with UNC13B ^{[6] [8]} and UNC13A. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000149927 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052301 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y (Feb 1995). "Doc2: a novel brain protein having two repeated C2-like domains". Biochem Biophys Res Commun. 206 (2): 439–48. doi:10.1006/bbrc.1995.1062. PMID   7826360.
6. Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (Oct 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc Natl Acad Sci U S A. 95 (19): 11418–22. Bibcode:1998PNAS...9511418M. doi: 10.1073/pnas.95.19.11418 . PMC   21657 . PMID   9736751.
7. "Entrez Gene: DOC2A double C2-like domains, alpha".
8. Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. doi: 10.1074/jbc.272.26.16081 . PMID   9195900.
9. "Protein unc-13 homolog A". UniProt.

Further reading

• Sakaguchi G, Orita S, Maeda M, Igarashi H, Takai Y (December 1995). "Molecular cloning of an isoform of Doc2 having two C2-like domains". Biochem. Biophys. Res. Commun. 217 (3): 1053–61. doi:10.1006/bbrc.1995.2876. PMID   8554557.
• Verhage M, de Vries KJ, Røshol H, Burbach JP, Gispen WH, Südhof TC (March 1997). "DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion". Neuron. 18 (3): 453–61. doi: 10.1016/S0896-6273(00)81245-3 . PMID   9115738. S2CID   17948539.
• Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y (November 1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065–8. doi: 10.1074/jbc.273.46.30065 . PMID   9804756.