DOK2

DOK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D9W, 2DLW
Identifiers
Aliases	DOK2 , p56DOK, p56dok-2, docking protein 2
External IDs	OMIM: 604997; MGI: 1332623; HomoloGene: 2957; GeneCards: DOK2; OMA:DOK2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8p21.3 Start 21,908,873 bp [1] End 21,913,690 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 D2|14 36.71 cM Start 70,766,036 bp [2] End 70,778,495 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood spleen lymph node appendix upper lobe of left lung testicle lower lobe of lung right lung Top expressed in granulocyte thymus tibiofemoral joint blood spleen morula embryo embryo lymph node fetal liver hematopoietic progenitor cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transmembrane receptor protein tyrosine kinase adaptor activity Cellular component cytosol Biological process cell surface receptor signaling pathway Ras protein signal transduction leukocyte migration signal transduction transmembrane receptor protein tyrosine kinase signaling pathway axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9046 13449 Ensembl ENSG00000147443 ENSMUSG00000022102 UniProt O60496 O70469 RefSeq (mRNA) NM_003974 NM_201349 NM_001317800 NM_001401272 NM_010071 RefSeq (protein) NP_001304729 NP_003965 NP_958728 NP_034201 NP_001388209 NP_001388210 Location (UCSC) Chr 8: 21.91 – 21.91 Mb Chr 14: 70.77 – 70.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene. ^{[5] [6] [7]}

Function

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. ^[7]

Interactions

DOK2 has been shown to interact with INPP5D ^[8] and TEK tyrosine kinase. ^{[9] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000147443 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022102 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Di Cristofano A, Carpino N, Dunant N, Friedland G, Kobayashi R, Strife A, Wisniewski D, Clarkson B, Pandolfi PP, Resh MD (March 1998). "Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins". J Biol Chem. 273 (9): 4827–30. doi: 10.1074/jbc.273.9.4827 . PMID   9478921.
6. Garcia A, Prabhakar S, Hughan S, Anderson TW, Brock CJ, Pearce AC, Dwek RA, Watson SP, Hebestreit HF, Zitzmann N (March 2004). "Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins". Blood. 103 (6): 2088–95. doi: 10.1182/blood-2003-07-2392 . PMID   14645010.
7. "Entrez Gene: DOK2 docking protein 2, 56kDa".
8. Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD (2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. 12 (5): 317–26. doi:10.1016/S0898-6568(00)00073-5. PMID   10822173.
9. Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene. 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. PMID   9764820. S2CID   20187169.
10. Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". EMBO J. 20 (21): 5919–28. doi:10.1093/emboj/20.21.5919. PMC   125712 . PMID   11689432.

Further reading

• Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. doi: 10.1067/mai.2000.107604 . PMID   10856136.
• Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene. 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. PMID   9764820. S2CID   20187169.
• Jones N, Dumont DJ (2000). "Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation". Curr. Biol. 9 (18): 1057–60. doi: 10.1016/S0960-9822(99)80458-8 . PMID   10508618. S2CID   18831513.
• Némorin JG, Duplay P (2000). "Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling". J. Biol. Chem. 275 (19): 14590–7. doi: 10.1074/jbc.275.19.14590 . PMID   10799545.
• Dunant NM, Wisniewski D, Strife A, et al. (2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. 12 (5): 317–26. doi:10.1016/S0898-6568(00)00073-5. PMID   10822173.
• Némorin JG, Laporte P, Bérubé G, Duplay P (2001). "p62dok negatively regulates CD2 signaling in Jurkat cells". J. Immunol. 166 (7): 4408–15. doi: 10.4049/jimmunol.166.7.4408 . PMID   11254695.
• Grimm J, Sachs M, Britsch S, et al. (2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation" (PDF). J. Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC   2150770 . PMID   11470823.
• Master Z, Jones N, Tran J, et al. (2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". EMBO J. 20 (21): 5919–28. doi:10.1093/emboj/20.21.5919. PMC   125712 . PMID   11689432.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Salomon AR, Ficarro SB, Brill LM, et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. Bibcode:2003PNAS..100..443S. doi: 10.1073/pnas.2436191100 . PMC   141014 . PMID   12522270.
• Jones N, Chen SH, Sturk C, et al. (2003). "A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function". Mol. Cell. Biol. 23 (8): 2658–68. doi:10.1128/MCB.23.8.2658-2668.2003. PMC   152553 . PMID   12665569.
• Master Z, Tran J, Bishnoi A, et al. (2003). "Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization". J. Biol. Chem. 278 (32): 30170–9. doi: 10.1074/jbc.M301339200 . PMID   12777393.
• Gérard A, Favre C, Garçon F, et al. (2004). "Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase". Oncogene. 23 (8): 1594–8. doi:10.1038/sj.onc.1207283. PMID   14647425. S2CID   11822165.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID   15144186.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Van Slyke P, Coll ML, Master Z, et al. (2005). "Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk". Mol. Cell. Biol. 25 (9): 3831–41. doi:10.1128/MCB.25.9.3831-3841.2005. PMC   1084282 . PMID   15831486.