DOK4

DOK4
Identifiers
Aliases	DOK4 , IRS-5, IRS5, docking protein 4
External IDs	OMIM: 608333; MGI: 2148865; HomoloGene: 10009; GeneCards: DOK4; OMA:DOK4 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q21 Start 57,471,922 bp [1] End 57,487,327 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 C5 Start 95,590,456 bp [2] End 95,602,958 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon tendon of biceps brachii right coronary artery duodenum Descending thoracic aorta rectum ganglionic eminence spinal ganglia ascending aorta skin of leg Top expressed in lumbar spinal ganglion interventricular septum intestinal villus ileum lip jejunum genital tubercle duodenum barrel cortex left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytosol Biological process axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55715 114255 Ensembl ENSG00000125170 ENSMUSG00000040631 UniProt Q8TEW6 Q99KE3 RefSeq (mRNA) NM_018110 NM_001330556 NM_053246 RefSeq (protein) NP_001317485 NP_060580 NP_001356547 NP_001356548 NP_001356549 NP_001356550 NP_444476 Location (UCSC) Chr 16: 57.47 – 57.49 Mb Chr 8: 95.59 – 95.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Docking protein 4 is a protein that in humans is encoded by the DOK4 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000125170 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040631 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Nov 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID   10493829.
6. "Entrez Gene: DOK4 docking protein 4".

Further reading

• Al-Sarraf N, Reiff JN, Hinrichsen J, et al. (2007). "DOK4/IRS-5 expression is altered in clear cell renal cell carcinoma". Int. J. Cancer. 121 (5): 992–8. doi: 10.1002/ijc.22776 . PMID   17443497. S2CID   41483929.
• Uchida M, Enomoto A, Fukuda T, et al. (2007). "Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase". J. Cell Sci. 119 (Pt 15): 3067–77. doi: 10.1242/jcs.03043 . PMID   16820412.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Cai D, Dhe-Paganon S, Melendez PA, et al. (2003). "Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5". J. Biol. Chem. 278 (28): 25323–30. doi: 10.1074/jbc.M212430200 . PMID   12730241.
• Favre C, Gérard A, Clauzier E, et al. (2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun. 4 (1): 40–5. doi: 10.1038/sj.gene.6363891 . PMID   12595900.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Grimm J, Sachs M, Britsch S, et al. (2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation" (PDF). J. Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC   2150770 . PMID   11470823.