In 1979 Dougherty became a member of the Caltech faculty, earning tenure in 1985. He pioneered the investigation of the role of cation–π interactions in protein structure, molecular recognition and enzyme catalysis.[1] He is the scientific co-founder of Neurion Pharmaceuticals, Inc. In 2005 he published a textbook entitled Modern Physical Organic Chemistry with co-author Eric V. Anslyn.
Dougherty is the recipient of multiple teaching awards including the Richard Badger Teaching Award (1992), the ASCIT Excellence in Teaching Award (1987 and 2000), and the Richard P. Feynman Prize for Excellence in Teaching (2010).[2][3] In 2009, he was elected to the National Academy of Sciences.[4]
Beene, D. B.; Brandt, G. S.; Zhong, W.; Zacharias, N. M.; Lester, H. A.; Dougherty, D. A. (Aug 2002). "Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine". Biochemistry. 41 (32): 10262–10269. doi:10.1021/bi020266d. ISSN0006-2960. PMID12162741.
Kearney, P. N.; Nowak, M. W.; Zhong, W.; Silverman, S. K.; Lester, H. A.; Dougherty, D. A. (Nov 1996). "Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: tests with novel side chains and with several agonists". Molecular Pharmacology. 50 (5): 1401–1412. doi:10.1016/S0026-895X(25)09576-8. ISSN0026-895X. PMID8913372.
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