Duncan Odom

Last updated
Duncan Odom
Born
Duncan Odom
Alma mater
Awards
Scientific career
Fields
Institutions
Thesis The application of metallointercalators in recognition of and charge transport in nucleic acids  (2001)
Doctoral advisor Jacqueline Barton [5]
Other academic advisors Richard A. Young [6]
Doctoral studentsChristina Ernst [7]
Website www.dkfz.de/en/regulatorische-genomik OOjs UI icon edit-ltr-progressive.svg

Duncan Odom is a research group leader at the German Cancer Research Center (DKFZ) in Heidelberg, and the Cancer Research UK Cambridge Institute (CRUK CI) at the University of Cambridge. [3] [8] [6] Previously he was as an associate faculty member at the Wellcome Trust Sanger Institute from 2011 to 2018. [4]

Contents

Education

Odom was educated at the New College of Florida where he was awarded a Bachelor of Arts degree in Chemistry in 1995. [4] He continued his study at California Institute of Technology (Caltech) where he was awarded a PhD in chemical engineering for research on DNA-binding metallo-intercalators supervised by Jacqueline Barton. [6] [5]

Career and research

After a period as a postdoctoral researcher [9] in genetics and genomics at the Whitehead Institute in Cambridge, Massachusetts with Richard A. Young, [4] he established his research group at the University of Cambridge in 2006. [6] His research investigates how transcription and transcriptional regulation vary during evolution, and its implications for diseases such as cancer, using high throughput biology methods to investigate genome evolution. [10] [11] [12] [13] As of 2017, according to Google Scholar his most highly-cited papers have been published in Cell , [14] Chemical Reviews , [15] and Science . [16] [17]

His research has been funded by the National Institute of Diabetes and Digestive and Kidney Diseases, [6] the Alfred P. Sloan Foundation, the European Research Council (ERC),[ citation needed ] the European Molecular Biology Organization (EMBO), the Wellcome Trust [18] and Cancer Research UK. [6] His former doctoral students include Christina Ernst. [7]

Awards and honours

Odom was awarded the Crick Lecture by the Royal Society in 2014 [1] [19] for his "pioneering work in the field of comparative functional genomics, which has changed our understanding of the evolution of mammalian transcriptional regulation." [1] He was awarded EMBO Membership in 2015, [2] and the Mary F. Lyon Medal from The Genetics Society in 2016. [20]

Related Research Articles

<span class="mw-page-title-main">Kim Nasmyth</span> British biochemist

Kim Ashley Nasmyth is an English geneticist, the Whitley Professor of Biochemistry at the University of Oxford, a Fellow of Trinity College, Oxford, former scientific director of the Research Institute of Molecular Pathology (IMP), and former head of the Department of Biochemistry, University of Oxford. He is best known for his work on the segregation of chromosomes during cell division.

<span class="mw-page-title-main">Ewan Birney</span> English businessman

John Frederick William Birney is joint director of EMBL's European Bioinformatics Institute (EMBL-EBI), in Hinxton, Cambridgeshire and deputy director general of the European Molecular Biology Laboratory (EMBL). He also serves as non-executive director of Genomics England, chair of the Global Alliance for Genomics and Health (GA4GH) and honorary professor of bioinformatics at the University of Cambridge. Birney has made significant contributions to genomics, through his development of innovative bioinformatics and computational biology tools. He previously served as an associate faculty member at the Wellcome Trust Sanger Institute.

David Moore Glover is a British geneticist and Research Professor of Biology and Biological Engineering at the California Institute of Technology. He served as Balfour Professor of Genetics at the University of Cambridge, a Wellcome Trust investigator in the Department of Genetics at the University of Cambridge, and Fellow of Fitzwilliam College, Cambridge. He serves as the first editor-in-chief of the open-access journal Open Biology published by the Royal Society.

Veronica van Heyningen is an English geneticist who specialises in the etiology of anophthalmia as an honorary professor at University College London (UCL). She previously served as head of medical genetics at the MRC Human Genetics Unit in Edinburgh and the president of The Genetics Society. In 2014 she became president of the Galton Institute. As of 2019 she chairs the diversity committee of the Royal Society, previously chaired by Uta Frith.

<span class="mw-page-title-main">Jim Cuthbert Smith</span>

Sir James Cuthbert Smith is Director of Science at the Wellcome Trust, Senior Group Leader at the Francis Crick Institute and President of the Council at Zoological Society of London.

<span class="mw-page-title-main">Sarah Teichmann</span> German bioinformatician

Sarah Amalia Teichmann is a German scientist who is head of cellular genetics at the Wellcome Sanger Institute and a visiting research group leader at the European Bioinformatics Institute (EMBL-EBI). She serves as director of research in the Cavendish Laboratory, at the University of Cambridge and a senior research fellow at Churchill College, Cambridge.

<span class="mw-page-title-main">Jane A. Langdale</span> British geneticist and academic

Jane Alison Langdale, is a British geneticist and academic. She is Professor of Plant Development in the Department of Biology at the University of Oxford and a Professorial Fellow at The Queen's College, Oxford.

Sir Hugh Reginald Brentnall Pelham, is a cell biologist who has contributed to our understanding of the body's response to rises in temperature through the synthesis of heat shock proteins. He served as director of the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) between 2006 and 2018.

<span class="mw-page-title-main">Jonathon Pines</span> British oncologist (born 1961)

Jonathon Noë Joseph Pines is Head of the Cancer Biology Division at the Institute of Cancer Research in London. He was formerly a senior group leader at the Gurdon Institute at the University of Cambridge.

<span class="mw-page-title-main">Robin Allshire</span>

Robin Campbell Allshire is Professor of Chromosome Biology at University of Edinburgh and a Wellcome Trust Principal Research Fellow. His research group at the Wellcome Trust Centre for Cell Biology focuses on the epigenetic mechanisms governing the assembly of specialised domains of chromatin and their transmission through cell division.

<span class="mw-page-title-main">Anne Ferguson-Smith</span> Mammalian developmental geneticist (born 1961)

Anne Carla Ferguson-Smith is a mammalian developmental geneticist. She is the Arthur Balfour Professor of Genetics and Pro-Vice Chancellor for Research and International Partnerships at the University of Cambridge. Formerly head of the Department of Genetics at the University of Cambridge, she is a Fellow of Darwin College, Cambridge and serves as President of the Genetics Society.

<span class="mw-page-title-main">Anne Ridley</span> Professor of Cell Biology

Anne Jacqueline Ridley is professor of Cell Biology and Head of School for Cellular and Molecular Medicine at the University of Bristol. She was previously a professor at King's College London.

James Briscoe is a senior group leader at the Francis Crick Institute in London and editor-in-chief of the journal Development.

<span class="mw-page-title-main">Richard Marais</span> Cancer researcher

Richard Malcolm Marais is Director of the Cancer Research UK (CRUK) Manchester Institute and Professor of Molecular Oncology at the University of Manchester.

<span class="mw-page-title-main">Richard Treisman</span> British scientist

Sir Richard Henry Treisman is a British scientist specialising in the molecular biology of cancer. Treisman is a director of research at the Francis Crick Institute in London.

<span class="mw-page-title-main">Neil Brockdorff</span> British biochemist (born 1958)

Neil Alexander Steven Brockdorff is a Wellcome Trust Principal Research Fellow and professor in the department of biochemistry at the University of Oxford. Brockdorff's research investigates gene and genome regulation in mammalian development. His interests are in the molecular basis of X-inactivation, the process that evolved in mammals to equalise X chromosome gene expression levels in XX females relative to XY males.

<span class="mw-page-title-main">Charles Swanton</span> British physician scientist

(Robert) Charles Swanton is British physician scientist specialising in oncology and cancer research. Swanton is a senior group leader at London's Francis Crick Institute, Royal Society Napier Professor in Cancer and thoracic medical oncologist at University College London and University College London Hospitals, co-director of the Cancer Research UK (CRUK) Lung Cancer Centre of Excellence, and Chief Clinician of Cancer Research UK.

Not to be confused with Rosemary Carpenter Fitzgerald.

<span class="mw-page-title-main">M. Madan Babu</span> Indian-American computational biologist

M. Madan Babu is an Indian-American computational biologist and bioinformatician. He is the endowed chair in biological data science and director of the center of excellence for data-driven discovery at St. Jude Children’s Research Hospital. Previously, he served as a programme leader at the MRC Laboratory of Molecular Biology (LMB).

Serena Nik-Zainal is a British-Malaysian clinician who is a consultant in clinical genetics and Cancer Research UK advanced clinician scientist at the University of Cambridge. She makes use of genomics for clinical applications. She was awarded the Crick Lecture by the Royal Society in 2021. Serena Nik-Zainal was also recognized as one of the 100 Influential Women in Oncology by OncoDaily.

References

  1. 1 2 3 Anon (2014). "Crick Lecture: Genetic control and the mammalian radiation". royalsociety.org. London: Royal Society. Archived from the original on 2017-05-03.
  2. 1 2 Anon (2015). "Duncan T. Odom". people.embo.org. Heidelberg: European Molecular Biology Organization.
  3. 1 2 Duncan Odom publications indexed by Google Scholar OOjs UI icon edit-ltr-progressive.svg
  4. 1 2 3 4 Anon (2016). "Dr Duncan Odom: Associate Faculty". sanger.ac.uk. Wellcome Trust. Archived from the original on 2016-09-07.
  5. 1 2 Odom, Duncan T. (2001). The application of metallointercalators in recognition of and charge transport in nucleic acids. caltech.edu (PhD thesis). California Institute of Technology. doi:10.7907/yz1f-w961. OCLC   874759941. ProQuest   251012080.
  6. 1 2 3 4 5 6 Duncan Odom ORCID   0000-0001-6201-5599
  7. 1 2 Ernst, Christina (2018). Transcriptional and developmental consequences of aneuploidy during male meiosis. cam.ac.uk (PhD thesis). University of Cambridge. doi:10.17863/CAM.25556. OCLC   1065352558. EThOS   uk.bl.ethos.753466. Lock-green.svg
  8. Duncan Odom publications from Europe PubMed Central
  9. Odom, Duncan T. (2014). "Survival strategies for choosing the right postdoc position". Genome Biology . 15 (3): 107. doi: 10.1186/gb4163 . PMC   4053951 . PMID   25001498. Open Access logo PLoS transparent.svg
  10. Odom, Duncan (2017). "Odom group: Transcription Regulation Laboratory". cruk.cam.ac.uk. Archived from the original on 2017-02-07.
  11. Villar, Diego; Berthelot, Camille; Aldridge, Sarah; Rayner, Tim F.; Lukk, Margus; Pignatelli, Miguel; Park, Thomas J.; Deaville, Robert; Erichsen, Jonathan T.; Jasinska, Anna J.; Turner, James M.A.; Bertelsen, Mads F.; Murchison, Elizabeth P.; Flicek, Paul; Odom, Duncan T. (2015). "Enhancer Evolution across 20 Mammalian Species". Cell. 160 (3): 554–566. doi:10.1016/j.cell.2015.01.006. ISSN   0092-8674. PMC   4313353 . PMID   25635462.
  12. Stefflova, Klara; Thybert, David; Wilson, Michael D.; Streeter, Ian; Aleksic, Jelena; Karagianni, Panagiota; Brazma, Alvis; Adams, David J.; Talianidis, Iannis; Marioni, John C.; Flicek, Paul; Odom, Duncan T. (2013). "Cooperativity and Rapid Evolution of Cobound Transcription Factors in Closely Related Mammals". Cell. 154 (3): 530–540. doi:10.1016/j.cell.2013.07.007. ISSN   0092-8674. PMC   3732390 . PMID   23911320. Open Access logo PLoS transparent.svg
  13. Ernst, Christina; Pike, Jeremy; Aitken, Sarah J; Long, Hannah K; Eling, Nils; Stojic, Lovorka; Ward, Michelle C; Connor, Frances; Rayner, Timothy F; Lukk, Margus; Klose, Robert J; Kutter, Claudia; Odom, Duncan T (2016). "Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis". eLife . 5. doi: 10.7554/eLife.20235 . ISSN   2050-084X. PMC   5161449 . PMID   27855777. Open Access logo PLoS transparent.svg
  14. Lee, Tong Ihn; Jenner, Richard G.; Boyer, Laurie A.; Guenther, Matthew G.; Levine, Stuart S.; Kumar, Roshan M.; Chevalier, Brett; Johnstone, Sarah E.; Cole, Megan F.; Isono, Kyo-ichi; Koseki, Haruhiko; Fuchikami, Takuya; Abe, Kuniya; Murray, Heather L.; Zucker, Jacob P.; Yuan, Bingbing; Bell, George W.; Herbolsheimer, Elizabeth; Hannett, Nancy M.; Sun, Kaiming; Odom, Duncan T.; Otte, Arie P.; Volkert, Thomas L.; Bartel, David P.; Melton, Douglas A.; Gifford, David K.; Jaenisch, Rudolf; Young, Richard A. (2006). "Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells". Cell. 125 (2): 301–313. doi:10.1016/j.cell.2006.02.043. ISSN   0092-8674. PMC   3773330 . PMID   16630818. Open Access logo PLoS transparent.svg
  15. Erkkila, Kathryn E.; Odom, Duncan T.; Barton, Jacqueline K. (1999). "Recognition and Reaction of Metallointercalators with DNA". Chemical Reviews. 99 (9): 2777–2796. doi:10.1021/cr9804341. ISSN   0009-2665. PMID   11749500.
  16. Lee, T. I. (2002). "Transcriptional Regulatory Networks in Saccharomyces cerevisiae". Science. 298 (5594): 799–804. Bibcode:2002Sci...298..799L. doi:10.1126/science.1075090. ISSN   0036-8075. PMID   12399584. S2CID   4841222.
  17. Odom, D. T. (2004). "Control of Pancreas and Liver Gene Expression by HNF Transcription Factors". Science. 303 (5662): 1378–1381. Bibcode:2004Sci...303.1378O. doi:10.1126/science.1089769. ISSN   0036-8075. PMC   3012624 . PMID   14988562. Open Access logo PLoS transparent.svg
  18. Anon (2017). "Investigator Awards in Science: people we've funded". wellcome.ac.uk. Wellcome Trust. Archived from the original on 2017-04-26.
  19. Event video: Genetic control and the mammalian radiation on YouTube
  20. "Mary Lyon Medal 2016 - Dr Duncan Odom - Genetics Society". Genetics.og.uk. Retrieved 28 November 2018.