EAPP

EAPP
Identifiers
Aliases	EAPP , BM036, C14orf11, E2F associated phosphoprotein
External IDs	OMIM: 609486 MGI: 1913516 HomoloGene: 10206 GeneCards: EAPP
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q13.1 Start 34,515,938 bp [1] End 34,539,704 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 C1 Start 54,717,125 bp [2] End 54,742,682 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon palpebral conjunctiva rectum skin of abdomen ganglionic eminence monocyte gastric mucosa islet of Langerhans bronchial epithelial cell caput epididymis Top expressed in interventricular septum yolk sac medial ganglionic eminence morula seminiferous tubule otic placode neural tube blastocyst blood ileum More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 55837 66266 Ensembl ENSG00000129518 ENSMUSG00000054302 UniProt Q56P03 Q5BU09 RefSeq (mRNA) NM_018453 NM_001318916 NM_025456 NM_001331162 RefSeq (protein) NP_001305845 NP_060923 NP_001318091 NP_079732 Location (UCSC) Chr 14: 34.52 – 34.54 Mb Chr 12: 54.72 – 54.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

E2F-associated phosphoprotein is a protein that in humans is encoded by the EAPP gene. ^{[5] [6]}

This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000129518 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054302 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Novy M, Pohn R, Andorfer P, Novy-Weiland T, Galos B, Schwarzmayr L, Rotheneder H (Apr 2005). "EAPP, a novel E2F binding protein that modulates E2F-dependent transcription". Mol Biol Cell. 16 (5): 2181–90. doi:10.1091/mbc.E04-11-0975. PMC   1087227 . PMID   15716352.
6. "Entrez Gene: C14orf11 chromosome 14 open reading frame 11".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kamnasaran D, Chen CP, Devriendt K, et al. (2005). "Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes". Genomics. 85 (5): 608–21. doi:10.1016/j.ygeno.2005.01.010. PMID   15820313.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.