EFEMP2

EFEMP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KL7
Identifiers
Aliases	EFEMP2 , ARCL1B, FBLN4, MBP1, UPH1, EGF containing fibulin like extracellular matrix protein 2, EGF containing fibulin extracellular matrix protein 2
External IDs	OMIM: 604633; MGI: 1891209; HomoloGene: 32339; GeneCards: EFEMP2; OMA:EFEMP2 - orthologs
Gene location (Mouse) Chr. Chromosome 19 (mouse) [1] Band 19|19 A Start 5,523,982 bp [1] End 5,532,545 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ascending aorta right coronary artery left coronary artery canal of the cervix left uterine tube popliteal artery myometrium left lobe of thyroid gland gastric mucosa Top expressed in calvaria stroma of bone marrow molar dermis decidua external carotid artery internal carotid artery ascending aorta belly cord efferent ductule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding extracellular matrix structural constituent protein binding Cellular component extracellular vesicle extracellular region basement membrane extracellular exosome extracellular space collagen-containing extracellular matrix Biological process elastic fiber assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30008 58859 Ensembl n/a ENSMUSG00000024909 UniProt O95967 Q9WVJ9 RefSeq (mRNA) NM_016938 NM_001164352 NM_021474 NM_001374680 RefSeq (protein) NP_058634 NP_001157824 NP_067449 NP_001361609 Location (UCSC) n/a Chr 19: 5.52 – 5.53 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

EGF-containing fibulin-like extracellular matrix protein 2 is a protein that in humans is encoded by the EFEMP2 gene. ^{[4] [5] [6]}

A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. EFEMP2 (also known as fibulin-4) contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is widely expressed in a range of adult and fetal tissues. ^[6]

Interactions

EFEMP2 has been shown to interact with P53. ^[7]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000024909 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Giltay R, Timpl R, Kostka G (Feb 2000). "Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4". Matrix Biol. 18 (5): 469–80. doi:10.1016/S0945-053X(99)00038-4. PMID   10601734.
5. Katsanis N, Venable S, Smith JR, Lupski JR (Sep 2000). "Isolation of a paralog of the Doyne honeycomb retinal dystrophy gene from the multiple retinopathy critical region on 11q13". Hum Genet. 106 (1): 66–72. doi:10.1007/s004390051011 (inactive 2024-03-29). PMID   10982184.
6. "Entrez Gene: EFEMP2 EGF-containing fibulin-like extracellular matrix protein 2".
7. Gallagher WM, Argentini M, Sierra V, Bracco L, Debussche L, Conseiller E (Jun 1999). "MBP1: a novel mutant p53-specific protein partner with oncogenic properties". Oncogene. 18 (24): 3608–16. doi: 10.1038/sj.onc.1202937 . ISSN   0950-9232. PMID   10380882.

Further reading

• Gallagher WM, Argentini M, Sierra V, et al. (1999). "MBP1: a novel mutant p53-specific protein partner with oncogenic properties". Oncogene. 18 (24): 3608–16. doi: 10.1038/sj.onc.1202937 . PMID   10380882.
• Gallagher WM, Greene LM, Ryan MP, et al. (2001). "Human fibulin-4: analysis of its biosynthetic processing and mRNA expression in normal and tumour tissues". FEBS Lett. 489 (1): 59–66. Bibcode:2001FEBSL.489...59G. doi: 10.1016/S0014-5793(00)02389-9 . PMID   11231014. S2CID   24614042.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID   12107411.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Xiang Y, Sekine T, Nakamura H, et al. (2006). "Fibulin-4 is a target of autoimmunity predominantly in patients with osteoarthritis". J. Immunol. 176 (5): 3196–204. doi: 10.4049/jimmunol.176.5.3196 . PMID   16493080.
• Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. Bibcode:2006Natur.440..497T. doi: 10.1038/nature04632 . PMID   16554811.
• Hucthagowder V, Sausgruber N, Kim KH, et al. (2006). "Fibulin-4: a novel gene for an autosomal recessive cutis laxa syndrome". Am. J. Hum. Genet. 78 (6): 1075–80. doi:10.1086/504304. PMC   1474103 . PMID   16685658.
• El-Hallous E, Sasaki T, Hubmacher D, et al. (2007). "Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin". J. Biol. Chem. 282 (12): 8935–46. doi: 10.1074/jbc.M608204200 . PMID   17255108.

External links

• GeneReview/NCBI/NIH/UW entry on EFEMP2-Related Cutis Laxa