EI24

EI24
Identifiers
Aliases	EI24 , EPG4, PIG8, TP53I8, autophagy associated transmembrane protein, EI24 autophagy associated transmembrane protein
External IDs	OMIM: 605170; MGI: 108090; HomoloGene: 3588; GeneCards: EI24; OMA:EI24 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q24.2 Start 125,569,280 bp [1] End 125,584,684 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 A4|9 20.68 cM Start 36,690,455 bp [2] End 36,708,689 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte right lobe of liver body of pancreas islet of Langerhans rectum gastrocnemius muscle stromal cell of endometrium muscle of thigh mucosa of esophagus skin of leg Top expressed in transitional epithelium of urinary bladder Ileal epithelium medullary collecting duct left lobe of liver renal corpuscle lacrimal gland trigeminal ganglion conjunctival fornix medial ganglionic eminence condyle More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 9538 13663 Ensembl ENSG00000149547 ENSMUSG00000062762 UniProt O14681 Q61070 RefSeq (mRNA) NM_001007277 NM_001290135 NM_004879 NM_001330419 NM_001199494 NM_007915 RefSeq (protein) NP_001277064 NP_001317348 NP_004870 NP_001186423 NP_031941 Location (UCSC) Chr 11: 125.57 – 125.58 Mb Chr 9: 36.69 – 36.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Etoposide-induced protein 2.4 homolog is a protein that in humans is encoded by the EI24 gene. ^{[5] [6] [7]}

This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000149547 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062762 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gu Z, Flemington C, Chittenden T, Zambetti GP (Jan 2000). "ei24, a p53 response gene involved in growth suppression and apoptosis". Mol Cell Biol. 20 (1): 233–41. doi:10.1128/MCB.20.1.233-241.2000. PMC   85079 . PMID   10594026.
6. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B (Sep 1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. Bibcode:1997Natur.389..300P. doi:10.1038/38525. PMID   9305847. S2CID   4429638.
7. "Entrez Gene: EI24 etoposide induced 2.4 mRNA".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Gu Z, Gilbert DJ, Valentine VA, et al. (2000). "The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9". Cytogenet. Cell Genet. 89 (3–4): 230–3. doi:10.1159/000015620. PMID   10965130. S2CID   20889902.
• Burns TF, Bernhard EJ, El-Deiry WS (2001). "Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo". Oncogene. 20 (34): 4601–12. doi:10.1038/sj.onc.1204484. PMID   11498783. S2CID   33518914.
• Gentile M, Ahnström M, Schön F, Wingren S (2002). "Candidate tumour suppressor genes at 11q23-q24 in breast cancer: evidence of alterations in PIG8, a gene involved in p53-induced apoptosis". Oncogene. 20 (53): 7753–60. doi:10.1038/sj.onc.1204993. PMID   11753653. S2CID   22664010.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.