EIF4EBP3

EIF4EBP3
Identifiers
Aliases	EIF4EBP3 , 4E-BP3, 4EBP3, eukaryotic translation initiation factor 4E binding protein 3
External IDs	OMIM: 603483; MGI: 1270847; HomoloGene: 37841; GeneCards: EIF4EBP3; OMA:EIF4EBP3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q31.3 Start 140,547,662 bp [1] End 140,549,576 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 B2 Start 36,797,113 bp [2] End 36,798,970 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube gastrocnemius muscle olfactory zone of nasal mucosa muscle of thigh right adrenal cortex body of stomach left adrenal cortex minor salivary glands fundus skin of leg Top expressed in ileum renal cortex proximal tubule bone marrow right kidney liver colon jejunum duodenum human kidney More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding eukaryotic initiation factor 4E binding translation repressor activity Cellular component cytoplasm eukaryotic translation initiation factor 4F complex membrane Biological process negative regulation of translation regulation of translation negative regulation of translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8637 108112 Ensembl ENSG00000243056 ENSMUSG00000090264 UniProt O60516 Q80VV3 RefSeq (mRNA) NM_003732 NM_201256 RefSeq (protein) NP_003723 NP_957708 Location (UCSC) Chr 5: 140.55 – 140.55 Mb Chr 18: 36.8 – 36.8 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 4E-binding protein 3 is a protein that in humans is encoded by the EIF4EBP3 gene. ^{[5] [6]}

Function

This gene encodes a member of the EIF4EBP family which derives its name from proteins that bind to eukaryotic initiation factor 4E and that prevent its assembly into EIF4F. Co-transcription of this gene and the neighboring upstream gene (MASK) generates a transcript (MASK-BP3) which encodes a fusion protein composed of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. ^[6]

Interactions

EIF4EBP3 has been shown to interact with EIF4E. ^{[5] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000243056 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000090264 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Poulin F, Gingras AC, Olsen H, Chevalier S, Sonenberg N (Jul 1998). "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family". J. Biol. Chem. 273 (22): 14002–7. doi: 10.1074/jbc.273.22.14002 . PMID   9593750.
6. "Entrez Gene: EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3".
7. Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG (Dec 2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. PMID   12482586. S2CID   24527449.

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Joshi B, Cameron A, Jagus R (2004). "Characterization of mammalian eIF4E-family members". Eur. J. Biochem. 271 (11): 2189–203. doi: 10.1111/j.1432-1033.2004.04149.x . PMID   15153109.
• Poulin F, Brueschke A, Sonenberg N (2003). "Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK". J. Biol. Chem. 278 (52): 52290–7. doi: 10.1074/jbc.M310761200 . PMID   14557257.
• Ferguson G, Mothe-Satney I, Lawrence JC (2003). "Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E". J. Biol. Chem. 278 (48): 47459–65. doi: 10.1074/jbc.M307949200 . PMID   14507920.
• Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG (2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. PMID   12482586. S2CID   24527449.