EIF4EBP3

EIF4EBP3
Identifiers
Aliases	EIF4EBP3 , 4E-BP3, 4EBP3, eukaryotic translation initiation factor 4E binding protein 3
External IDs	OMIM: 603483 MGI: 1270847 HomoloGene: 37841 GeneCards: EIF4EBP3
Gene location (Human)
Chr.	Chromosome 5 (human)
End	140,549,576 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	36,798,970 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; gastrocnemius muscle; ; body of stomach; ; minor salivary gland; ; fundus; ; skeletal muscle tissue; ; skin of abdomen; ; body of pancreas; ; subcutaneous adipose tissue; ; right lobe of liver;
	Top expressed in
	ileum; ; renal cortex; ; proximal tubule; ; bone marrow; ; liver; ; colon; ; jejunum; ; duodenum; ; kidney; ; pancreas;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; eukaryotic initiation factor 4E binding ; translation repressor activity ;
Cellular component	cytoplasm ; eukaryotic translation initiation factor 4F complex ; membrane ;
Biological process	negative regulation of translation ; regulation of translation ; negative regulation of translational initiation ;
	Sources:Amigo / QuickGO
Orthologs
	8637
	108112
	ENSG00000243056
	ENSMUSG00000090264
	O60516
	Q80VV3
	NM_003732
	NM_201256
	NP_003723
	NP_957708
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Eukaryotic translation initiation factor 4E-binding protein 3 is a protein that in humans is encoded by the EIF4EBP3 gene.^[5]^[6]

Function

This gene encodes a member of the EIF4EBP family which derives its name from proteins that bind to eukaryotic initiation factor 4E and that prevent its assembly into EIF4F. Co-transcription of this gene and the neighboring upstream gene (MASK) generates a transcript (MASK-BP3) which encodes a fusion protein composed of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.^[6]

Interactions

EIF4EBP3 has been shown to interact with EIF4E.^[5]^[7]

Related Research Articles

Eukaryotic translation initiation factor 4E-binding protein 1 is a protein that in humans is encoded by the EIF4EBP1 gene.

Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein that in humans is encoded by the EIF4E gene.

Eukaryotic translation initiation factor 4 gamma 2 is a protein that in humans is encoded by the EIF4G2 gene.

Eukaryotic translation initiation factor 3 subunit E (eIF3e) is a protein that in humans is encoded by the EIF3E gene.

Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene.

Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene.

Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the EIF3A gene. It is one of the subunits of Eukaryotic initiation factor 3 (eIF3) a multiprotein complex playing major roles in translation initiation in eukaryotes.

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.

Eukaryotic translation initiation factor 3 subunit I (eIF3i) is a protein that in humans is encoded by the EIF3I gene.

Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene. The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template. Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.

Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene.

Eukaryotic translation initiation factor 3 subunit B (eIF3b) is a protein that in humans is encoded by the EIF3B gene.

Eukaryotic translation initiation factor 3 subunit C (eIF3c) is a protein that in humans is encoded by the EIF3C gene.

Eukaryotic translation initiation factor 3 subunit H (eIF3h) is a protein that in humans is encoded by the EIF3H gene.

Eukaryotic translation initiation factor 3 subunit G (eIF3g) is a protein that in humans is encoded by the EIF3G gene.

Eukaryotic translation initiation factor 3 subunit F (eIF3f) is a protein that in humans is encoded by the EIF3F gene.

Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a protein that in humans is encoded by the EIF3D gene.

Eukaryotic translation initiation factor 3 subunit J (eIF3j) is a protein that in humans is encoded by the EIF3J gene.

Eukaryotic translation initiation factor 4E-binding protein 2 is a protein that in humans is encoded by the EIF4EBP2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000243056 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090264 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Poulin F, Gingras AC, Olsen H, Chevalier S, Sonenberg N (Jul 1998). "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family". J. Biol. Chem. 273 (22): 14002–7. doi: 10.1074/jbc.273.22.14002 . PMID 9593750.
1 2 "Entrez Gene: EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3".
↑ Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG (Dec 2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. PMID 12482586. S2CID 24527449.

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Joshi B, Cameron A, Jagus R (2004). "Characterization of mammalian eIF4E-family members". Eur. J. Biochem. 271 (11): 2189–203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
Poulin F, Brueschke A, Sonenberg N (2003). "Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK". J. Biol. Chem. 278 (52): 52290–7. doi: 10.1074/jbc.M310761200 . PMID 14557257.
Ferguson G, Mothe-Satney I, Lawrence JC (2003). "Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E". J. Biol. Chem. 278 (48): 47459–65. doi: 10.1074/jbc.M307949200 . PMID 14507920.
Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG (2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. PMID 12482586. S2CID 24527449.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000243056 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090264 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9593750-5] 1 2 Poulin F, Gingras AC, Olsen H, Chevalier S, Sonenberg N (Jul 1998). "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family". J. Biol. Chem. 273 (22): 14002–7. doi: 10.1074/jbc.273.22.14002 . PMID 9593750.

[entrez-6] 1 2 "Entrez Gene: EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3".

[pmid12482586-7] Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG (Dec 2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. PMID 12482586. S2CID 24527449.

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EIF4EBP3

Contents

Function

Interactions

Related Research Articles

References

Further reading