EIF4ENIF1

EIF4ENIF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5ANR
Identifiers
Aliases	EIF4ENIF1 , 4E-T, Clast4, eukaryotic translation initiation factor 4E nuclear import factor 1
External IDs	OMIM: 607445 MGI: 1921453 HomoloGene: 10522 GeneCards: EIF4ENIF1
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q12.2 Start 31,436,977 bp [1] End 31,496,108 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 A1|11 2.24 cM Start 3,152,392 bp [2] End 3,194,588 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sural nerve sperm cerebellar cortex cerebellar hemisphere cerebellar vermis ganglionic eminence gastric mucosa gastrocnemius muscle popliteal artery Top expressed in secondary oocyte interventricular septum thymus body of femur yolk sac somite visual cortex superior cervical ganglion maxillary prominence saccule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding mRNA binding RNA binding nuclear export signal receptor activity Cellular component cytoplasm cytosol PML body nuclear speck P-body membrane intracellular membrane-bounded organelle nucleus Biological process protein transport stem cell population maintenance negative regulation of translation negative regulation of neuron differentiation transport nuclear export Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56478 74203 Ensembl ENSG00000184708 ENSMUSG00000020454 UniProt Q9NRA8 Q9EST3 RefSeq (mRNA) NM_001164501 NM_001164502 NM_019843 NM_001166547 NM_001166548 NM_001166549 NM_023743 RefSeq (protein) NP_001157973 NP_001157974 NP_062817 NP_001160019 NP_001160020 NP_001160021 NP_076232 Location (UCSC) Chr 22: 31.44 – 31.5 Mb Chr 11: 3.15 – 3.19 Mb PubMed search [3] [4]
Wikidata
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Eukaryotic translation initiation factor 4E transporter is a protein that in humans is encoded by the EIF4ENIF1 gene. ^{[5] [6]}

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic;its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. ^[6]

Interactions

EIF4ENIF1 has been shown to interact with EIF4E. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000184708 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020454 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dostie J, Ferraiuolo M, Pause A, Adam SA, Sonenberg N (Aug 2000). "A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E". EMBO J. 19 (12): 3142–56. doi:10.1093/emboj/19.12.3142. PMC   203362 . PMID   10856257.
6. "Entrez Gene: EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Warner DR, Roberts EA, Greene RM, Pisano MM (2004). "Identification of novel Smad binding proteins". Biochem. Biophys. Res. Commun. 312 (4): 1185–90. doi:10.1016/j.bbrc.2003.11.049. PMID   14651998.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID   15345747.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andrei MA, Ingelfinger D, Heintzmann R, et al. (2005). "A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies". RNA. 11 (5): 717–27. doi:10.1261/rna.2340405. PMC   1370757 . PMID   15840819.
• Ferraiuolo MA, Basak S, Dostie J, et al. (2005). "A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay". J. Cell Biol. 170 (6): 913–24. doi:10.1083/jcb.200504039. PMC   2171455 . PMID   16157702.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Wichroski MJ, Robb GB, Rana TM (2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies". PLOS Pathog. 2 (5): e41. doi: 10.1371/journal.ppat.0020041 . PMC   1458959 . PMID   16699599.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569.
• Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC   1891335 . PMID   17567994.