ELOVL5

ELOVL5
Identifiers
Aliases	ELOVL5 , HELO1, SCA38, dJ483K16.1, ELOVL fatty acid elongase 5
External IDs	OMIM: 611805 MGI: 1916051 HomoloGene: 41449 GeneCards: ELOVL5
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p12.1 Start 53,267,398 bp [1] End 53,349,179 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 E1 Start 77,824,646 bp [2] End 77,891,801 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula secondary oocyte lactiferous duct tibia trigeminal ganglion parietal pleura spinal ganglia inferior ganglion of vagus nerve retinal pigment epithelium pericardium Top expressed in Paneth cell carotid body cumulus cell conjunctival fornix adrenal gland facial motor nucleus substantia nigra stria vascularis anterior horn of spinal cord right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transferase activity 3-oxo-arachidoyl-CoA synthase activity 3-oxo-cerotoyl-CoA synthase activity fatty acid elongase activity 3-oxo-lignoceronyl-CoA synthase activity very-long-chain 3-ketoacyl-CoA synthase activity Cellular component dendritic tree dendrite integral component of membrane cell projection endoplasmic reticulum membrane neuronal cell body membrane endoplasmic reticulum integral component of endoplasmic reticulum membrane Biological process lipid metabolism fatty acid biosynthetic process linoleic acid metabolic process alpha-linolenic acid metabolic process fatty acid metabolic process unsaturated fatty acid biosynthetic process fatty acid elongation, polyunsaturated fatty acid very long-chain fatty acid biosynthetic process fatty acid elongation, monounsaturated fatty acid long-chain fatty-acyl-CoA biosynthetic process positive regulation of fatty acid biosynthetic process fatty acid elongation, saturated fatty acid sphingolipid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60481 68801 Ensembl ENSG00000012660 ENSMUSG00000032349 UniProt Q9NYP7 Q8BHI7 RefSeq (mRNA) NM_021814 NM_001242828 NM_001242830 NM_001242831 NM_001301856 NM_134255 RefSeq (protein) NP_001229757 NP_001229759 NP_001229760 NP_001288785 NP_068586 NP_599016 Location (UCSC) Chr 6: 53.27 – 53.35 Mb Chr 9: 77.82 – 77.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Elongation of very long chain fatty acids protein 5 is a protein that in humans is encoded by the ELOVL5 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000012660 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032349 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Leonard AE, Bobik EG, Dorado J, Kroeger PE, Chuang LT, Thurmond JM, Parker-Barnes JM, Das T, Huang YS, Mukerji P (Jan 2001). "Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids". Biochem J. 350 Pt 3 (Pt 3): 765–70. doi:10.1042/0264-6021:3500765. PMC   1221308 . PMID   10970790.
6. "Entrez Gene: ELOVL5 ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Barragan I, Marcos I, Borrego S, Antiñolo G (2006). "Mutation screening of three candidate genes, ELOVL5, SMAP1 and GLULD1 in autosomal recessive retinitis pigmentosa". Int. J. Mol. Med. 16 (6): 1163–7. doi:10.3892/ijmm.16.6.1163. PMID   16273301.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.