ELP3

ELP3
Identifiers
Aliases	ELP3 , KAT9, elongator acetyltransferase complex subunit 3
External IDs	OMIM: 612722; MGI: 1921445; HomoloGene: 7105; GeneCards: ELP3; OMA:ELP3 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	28,191,156 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	65,830,524 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; endometrium; ; Achilles tendon; ; epithelium of colon; ; germinal epithelium; ; internal globus pallidus; ; primary visual cortex; ; seminal vesicula;
	Top expressed in
	primitive streak; ; ventricular zone; ; somite; ; epiblast; ; dentate gyrus of hippocampal formation granule cell; ; muscle of thigh; ; maxillary prominence; ; calvaria; ; mandibular prominence; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; RNA polymerase II complex binding ; iron-sulfur cluster binding ; H4 histone acetyltransferase activity ; H3 histone acetyltransferase activity ; metal ion binding ; histone acetyltransferase activity ; phosphorylase kinase regulator activity ; protein binding ; catalytic activity ; acyltransferase activity ; acetyltransferase activity ;
Cellular component	cytoplasm ; elongator holoenzyme complex ; nucleolus ; histone acetyltransferase complex ; transcription elongation factor complex ; nucleus ;
Biological process	regulation of transcription, DNA-templated ; positive regulation of cell migration ; regulation of transcription by RNA polymerase II ; transcription elongation from RNA polymerase II promoter ; neuron migration ; transcription, DNA-templated ; nervous system development ; central nervous system development ; histone H3 acetylation ; histone H4 acetylation ; regulation of protein kinase activity ; tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation ; histone acetylation ;
	Sources:Amigo / QuickGO
Orthologs
	55140
	74195
	ENSG00000134014
	ENSMUSG00000022031
	Q9H9T3
	Q9CZX0
NM_001284220 ; NM_001284222 ; NM_001284224 ; NM_001284225 ; NM_001284226 ;
	NM_018091
	NM_001253812 ; NM_028811
NP_001271149 ; NP_001271151 ; NP_001271153 ; NP_001271154 ; NP_001271155 ;
	NP_060561
	NP_001240741 ; NP_083087
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 28, 2024

Elongator complex protein 3, also named KAT9, is a protein that in humans is encoded by the ELP3 gene.^[5]^[6] ELP3 is the catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. ELP3 supports the migration and branching of projection neurons through acetylation of alpha-tubulin in the developing cerebral cortex.^[7] In mammals, ELP3 is important for paternal DNA demethylation after fertilization.^[8] ELP3 is potentially involved in cellular redox homeostasis by mediating the acetylation of glucose-6-phosphate dehydrogenase.^[9] Besides, ELP3 may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.

Related Research Articles

<span class="mw-page-title-main">Epigenome</span> Biological term

In biology, the epigenome of an organism is the collection of chemical changes to its DNA and histone proteins that affects when, where, and how the DNA is expressed; these changes can be passed down to an organism's offspring via transgenerational stranded epigenetic inheritance. Changes to the epigenome can result in changes to the structure of chromatin and changes to the function of the genome.

Histone H3.3 is a protein that in humans is encoded by the H3F3A and H3F3B genes. It plays an essential role in maintaining genome integrity during mammalian development.

Histone H2B type 1-D is a protein that in humans is encoded by the HIST1H2BD gene.

Cleavage and polyadenylation specificity factor subunit 2 is a protein that in humans is encoded by the CPSF2 gene. This protein is a subunit of the cleavage and polyadenylation specificity factor (CPSF) complex which plays a key role in pre-mRNA 3' end processing and polyadenylation. The CPSF2 protein connects the two subunits of the complex, mCF and mPSF. Its structure contributes both to the stability of the subunits interaction and to the flexibility of the complex necessary for function. This protein has been identified as an essential subunit of the complex as certain mutations in the region inhibit CPSF complex formation.

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.

Histone H2B type 1-L is a protein that in humans is encoded by the HIST1H2BL gene.

Histone H2B type 1-N is a protein that in humans is encoded by the HIST1H2BN gene.

Histone H2B type 1-O is a protein that in humans is encoded by the HIST1H2BO gene.

Histone H2B type 1-M is a protein that in humans is encoded by the HIST1H2BM gene.

Histone H2B type 1-H is a protein that in humans is encoded by the HIST1H2BH gene.

Histone H2B type 1-A is a protein that in humans is encoded by the HIST1H2BA gene.

TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the TAF1A gene.

Transcription termination factor 1 is a protein that in humans is encoded by the TTF1 gene.

Repressor of RNA polymerase III transcription MAF1 homolog is a protein that in humans is encoded by the MAF1 gene.

Histone H2A.V is a protein that in humans is encoded by the H2AFV gene.

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.

Elongation protein 4 homolog , also known as ELP4, is a protein which in humans is encoded by the ELP4 gene.

Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BE gene.

Histone H2A.J is a protein that in humans is encoded by the H2AFJ gene.

H3K36ac is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the acetylation at the 36th lysine residue of the histone H3 protein.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000134014 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022031 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ (Jan 2002). "Purification and characterization of the human elongator complex". J Biol Chem. 277 (4): 3047–52. doi: 10.1074/jbc.M110445200 . PMID 11714725.
↑ "Entrez Gene: ELP3 elongation protein 3 homolog (S. cerevisiae)".
↑ Creppe C, Malinouskaya L, Volvert ML, Gillard M, Close P, Malaise O, Laguesse S, Cornez I, Rahmouni S, Ormenese S, Belachew S, Malgrange B, Chapelle JP, Siebenlist U, Moonen G, Chariot A, Nguyen L (Feb 2009). "Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin". Cell. 136 (3): 551–64. doi: 10.1016/j.cell.2008.11.043 . PMID 19185337. S2CID 18351772.
↑ Okada Y, Yamagata K, Hong K, Wakayama T, Zhang Y (Jan 2010). "A role for the elongator complex in zygotic paternal genome demethylation". Nature. 463 (7280): 554–8. Bibcode:2010Natur.463..554O. doi:10.1038/nature08732. PMC 2834414 . PMID 20054296.
↑ Wang YP, Zhou LS, Zhao YZ, Wang SW, Chen LL, Liu LX, Ling ZQ, Hu FJ, Sun YP, Zhang JY, Yang C, Yang Y, Xiong Y, Guan KL, Ye D (Jun 2014). "Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress". The EMBO Journal. 33 (12): 1304–20. doi:10.1002/embj.201387224. PMC 4194121 . PMID 24769394.

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Kim JH, Lane WS, Reinberg D (2002). "Human Elongator facilitates RNA polymerase II transcription through chromatin". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1241–6. Bibcode:2002PNAS...99.1241K. doi: 10.1073/pnas.251672198 . PMC 122174 . PMID 11818576.
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Han Q, Hou X, Su D, et al. (2007). "hELP3 subunit of the Elongator complex regulates the transcription of HSP70 gene in human cells". Acta Biochim. Biophys. Sin. (Shanghai). 39 (6): 453–61. doi: 10.1111/j.1745-7270.2007.00293.x . PMID 17558451.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000134014 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022031 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11714725-5] Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ (Jan 2002). "Purification and characterization of the human elongator complex". J Biol Chem. 277 (4): 3047–52. doi: 10.1074/jbc.M110445200 . PMID 11714725.

[entrez-6] "Entrez Gene: ELP3 elongation protein 3 homolog (S. cerevisiae)".

[7] Creppe C, Malinouskaya L, Volvert ML, Gillard M, Close P, Malaise O, Laguesse S, Cornez I, Rahmouni S, Ormenese S, Belachew S, Malgrange B, Chapelle JP, Siebenlist U, Moonen G, Chariot A, Nguyen L (Feb 2009). "Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin". Cell. 136 (3): 551–64. doi: 10.1016/j.cell.2008.11.043 . PMID 19185337. S2CID 18351772.

[8] Okada Y, Yamagata K, Hong K, Wakayama T, Zhang Y (Jan 2010). "A role for the elongator complex in zygotic paternal genome demethylation". Nature. 463 (7280): 554–8. Bibcode:2010Natur.463..554O. doi:10.1038/nature08732. PMC 2834414 . PMID 20054296.

[9] Wang YP, Zhou LS, Zhao YZ, Wang SW, Chen LL, Liu LX, Ling ZQ, Hu FJ, Sun YP, Zhang JY, Yang C, Yang Y, Xiong Y, Guan KL, Ye D (Jun 2014). "Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress". The EMBO Journal. 33 (12): 1304–20. doi:10.1002/embj.201387224. PMC 4194121 . PMID 24769394.

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ELP3

Related Research Articles

References

Further reading