ELP3

ELP3
Identifiers
Aliases	ELP3 , KAT9, elongator acetyltransferase complex subunit 3
External IDs	OMIM: 612722; MGI: 1921445; HomoloGene: 7105; GeneCards: ELP3; OMA:ELP3 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8p21.1 Start 28,089,673 bp [1] End 28,191,156 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 D1 Start 65,767,898 bp [2] End 65,830,524 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus endometrium Achilles tendon epithelium of colon germinal epithelium internal globus pallidus primary visual cortex seminal vesicula Top expressed in primitive streak ventricular zone somite epiblast dentate gyrus of hippocampal formation granule cell muscle of thigh maxillary prominence calvaria mandibular prominence neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity RNA polymerase II complex binding iron-sulfur cluster binding H4 histone acetyltransferase activity H3 histone acetyltransferase activity metal ion binding histone acetyltransferase activity phosphorylase kinase regulator activity protein binding catalytic activity acyltransferase activity acetyltransferase activity Cellular component cytoplasm elongator holoenzyme complex nucleolus histone acetyltransferase complex transcription elongation factor complex nucleus Biological process regulation of transcription, DNA-templated positive regulation of cell migration regulation of transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter neuron migration transcription, DNA-templated nervous system development central nervous system development histone H3 acetylation histone H4 acetylation regulation of protein kinase activity tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation histone acetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55140 74195 Ensembl ENSG00000134014 ENSMUSG00000022031 UniProt Q9H9T3 Q9CZX0 RefSeq (mRNA) NM_001284220 NM_001284222 NM_001284224 NM_001284225 NM_001284226 NM_018091 NM_001253812 NM_028811 RefSeq (protein) NP_001271149 NP_001271151 NP_001271153 NP_001271154 NP_001271155 NP_060561 NP_001240741 NP_083087 Location (UCSC) Chr 8: 28.09 – 28.19 Mb Chr 14: 65.77 – 65.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Elongator complex protein 3, also named KAT9, is a protein that in humans is encoded by the ELP3 gene. ^{[5] [6]} ELP3 is the catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. ELP3 supports the migration and branching of projection neurons through acetylation of alpha-tubulin in the developing cerebral cortex. ^[7] In mammals, ELP3 is important for paternal DNA demethylation after fertilization. ^[8] ELP3 is potentially involved in cellular redox homeostasis by mediating the acetylation of glucose-6-phosphate dehydrogenase. ^[9] Besides, ELP3 may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.

References

1. GRCh38: Ensembl release 89: ENSG00000134014 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022031 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ (Jan 2002). "Purification and characterization of the human elongator complex". J Biol Chem. 277 (4): 3047–52. doi: 10.1074/jbc.M110445200 . PMID   11714725.
6. "Entrez Gene: ELP3 elongation protein 3 homolog (S. cerevisiae)".
7. Creppe C, Malinouskaya L, Volvert ML, Gillard M, Close P, Malaise O, Laguesse S, Cornez I, Rahmouni S, Ormenese S, Belachew S, Malgrange B, Chapelle JP, Siebenlist U, Moonen G, Chariot A, Nguyen L (Feb 2009). "Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin". Cell. 136 (3): 551–64. doi: 10.1016/j.cell.2008.11.043 . PMID   19185337. S2CID   18351772.
8. Okada Y, Yamagata K, Hong K, Wakayama T, Zhang Y (Jan 2010). "A role for the elongator complex in zygotic paternal genome demethylation". Nature. 463 (7280): 554–8. Bibcode:2010Natur.463..554O. doi:10.1038/nature08732. PMC   2834414 . PMID   20054296.
9. Wang YP, Zhou LS, Zhao YZ, Wang SW, Chen LL, Liu LX, Ling ZQ, Hu FJ, Sun YP, Zhang JY, Yang C, Yang Y, Xiong Y, Guan KL, Ye D (Jun 2014). "Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress". The EMBO Journal. 33 (12): 1304–20. doi:10.1002/embj.201387224. PMC   4194121 . PMID   24769394.

Further reading

• Rengo F, Brevetti G, Piscione F, et al. (1977). "[Behavior of some metabolic parameters during post-ischemic and post-contraction vasodilation in normal subjects]". Bollettino della Società italiana di cardiologia. 20 (12): 1801–6. PMID   10936.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Ninomiya Y, Okada M, Kotomura N, et al. (1996). "Genomic organization and isoforms of the mouse ELP gene". J. Biochem. 118 (2): 380–9. doi: 10.1093/oxfordjournals.jbchem.a124918 . PMID   8543574.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Kim JH, Lane WS, Reinberg D (2002). "Human Elongator facilitates RNA polymerase II transcription through chromatin". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1241–6. Bibcode:2002PNAS...99.1241K. doi: 10.1073/pnas.251672198 . PMC   122174 . PMID   11818576.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Kouskouti A, Talianidis I (2005). "Histone modifications defining active genes persist after transcriptional and mitotic inactivation". EMBO J. 24 (2): 347–57. doi:10.1038/sj.emboj.7600516. PMC   545808 . PMID   15616580.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Han Q, Hou X, Su D, et al. (2007). "hELP3 subunit of the Elongator complex regulates the transcription of HSP70 gene in human cells". Acta Biochim. Biophys. Sin. (Shanghai). 39 (6): 453–61. doi: 10.1111/j.1745-7270.2007.00293.x . PMID   17558451.