ENAH (gene)

ENAH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HO2, 2IYB, 2XQN, 4MY6
Identifiers
Aliases	ENAH , ENA, MENA, NDPP1, enabled homolog (Drosophila), actin regulator
External IDs	OMIM: 609061 MGI: 108360 HomoloGene: 134005 GeneCards: ENAH
Gene location (Human)
Chr.	Chromosome 1 (human)
End	225,653,142 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	181,847,555 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; secondary oocyte; ; vena cava; ; urethra; ; seminal vesicula; ; cardia; ; Achilles tendon; ; sural nerve; ; bronchial epithelial cell; ; ganglionic eminence;
	Top expressed in
	ascending aorta; ; seminal vesicula; ; stria vascularis; ; medullary collecting duct; ; aortic valve; ; substantia nigra; ; abdominal wall; ; medial geniculate nucleus; ; fossa; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding ; WW domain binding ; actin binding ; protein binding ; profilin binding ;
Cellular component	filopodium ; cell junction ; plasma membrane ; cell projection ; synapse ; cytoskeleton ; focal adhesion ; lamellipodium ; cytoplasm ; cytosol ;
Biological process	axon guidance ; actin polymerization or depolymerization ; actin polymerization-dependent cell motility ;
	Sources:Amigo / QuickGO
Orthologs
	55740
	13800
	ENSG00000154380
	ENSMUSG00000022995
	Q8N8S7
	Q03173
	NM_001008493 ; NM_018212
	NM_001083120 ; NM_001083121 ; NM_008680 ; NM_010135
	NP_001008493 ; NP_060682 ; NP_001364410 ; NP_001364411 ; NP_001364412 Contents Interactions ; References ; Further reading ;
	NP_001076589 ; NP_001076590 ; NP_032706 ; NP_034265
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 24, 2023

Protein enabled homolog is a protein that in humans is encoded by the ENAH gene.^[5]^[6]

Interactions

ENAH has been shown to interact with ABI1,^[7] ZYX,^[7]^[8] and PCARE.^[9]

Related Research Articles

ENA/VASP homology proteins or EVH proteins are a family of closely related proteins involved in cell motility in vertebrate and invertebrate animals. EVH proteins are modular proteins that are involved in actin polymerization, as well as interactions with other proteins. Within the cell, Ena/VASP proteins are found at the leading edge of Lamellipodia and at the tips of filopodia. Ena, the founding member of the family was discovered in a drosophila genetic screen for mutations that act as dominant suppressors of the abl non receptor tyrosine kinase. Invertebrate animals have one Ena homologue, whereas mammals have three, named Mena, VASP, and Evl.

Profilin-1 is a protein that in humans is encoded by the PFN1 gene.

Vasodilator-stimulated phosphoprotein is a protein that in humans is encoded by the VASP gene.

Neural Wiskott–Aldrich syndrome protein is a protein that in humans is encoded by the WASL gene.

Zyxin is a protein that in humans is encoded by the ZYX gene.

Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene.

WAS/WASL-interacting protein (WIP) is a protein that in humans is encoded by the WIPF1 gene.

ArgBP2 protein, also referred to as Sorbin and SH3 domain-containing protein 2 is a protein that in humans is encoded by the SORBS2 gene. ArgBP2 belongs to the a small family of adaptor proteins having sorbin homology (SOHO) domains. ArgBP2 is highly abundant in cardiac muscle cells at sarcomeric Z-disc structures, and is expressed in other cells at actin stress fibers and the nucleus.

FYN binding protein (FYB-120/130), also known as FYB, ADAP, and SLAP-130 is a protein that is encoded by the FYB gene in humans. The protein is expressed in T cells, monocytes, mast cells, macrophages, NK cells, but not B cells. FYB is a multifunctional protein involved in post-activation T cell signaling, lymphocyte cytokine production, cell adhesion, and actin remodeling.

Profilin-2 is a protein that in humans is encoded by the PFN2 gene.

Protein diaphanous homolog 1 is a protein that in humans is encoded by the DIAPH1 gene.

Ena/VASP-like protein is a member of the Ena/VASP family of proteins that in humans is encoded by the EVL gene.

FH1/FH2 domain-containing protein 1 is a protein that in humans is encoded by the FHOD1 gene.

LIM and SH3 domain protein 1 is a protein that in humans is encoded by the LASP1 gene.

Acid-sensing ion channel 2 (ASIC2) also known as amiloride-sensitive cation channel 1, neuronal (ACCN1) or brain sodium channel 1 (BNaC1) is a protein that in humans is encoded by the ASIC2 gene. The ASIC2 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals. The cDNA of this gene was first cloned in 1996. The ASIC genes have splicing variants that encode different proteins that are called isoforms.

Filamin-binding LIM protein 1 is a protein that in humans is encoded by the FBLIM1 gene.

Ras-associated and pleckstrin homology domains-containing protein 1 is a protein that in humans is encoded by the RAPH1 gene.

<span class="mw-page-title-main">Actin assembly-inducing protein</span>

The Actin assembly-inducing protein (ActA) is a protein encoded and used by Listeria monocytogenes to propel itself through a mammalian host cell. ActA is a bacterial surface protein comprising a membrane-spanning region. In a mammalian cell the bacterial ActA interacts with the Arp2/3 complex and actin monomers to induce actin polymerization on the bacterial surface generating an actin comet tail. The gene encoding ActA is named actA or prtB.

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP), also known as APBB1-interacting protein 1 or Rap1-GTP-interacting adapter molecule (RIAM) is a protein that in humans is encoded by the APBB1IP gene.

WH1 domain is an evolutionary conserved protein domain found on WASP proteins, which are often involved in actin polymerization.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000154380 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022995 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sazuka T, Tomooka Y, Kathju S, Ikawa Y, Noda M, Kumar S (October 1992). "Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1132 (3): 240–248. doi:10.1016/0167-4781(92)90156-t. hdl: 2027.42/29785 . PMID 1420303.
↑ "Entrez Gene: ENAH enabled homolog (Drosophila)".
1 2 Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (June 2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". The Journal of Biological Chemistry. 278 (24): 21685–21692. doi: 10.1074/jbc.M301447200 . PMID 12672821.
↑ Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (July 2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". The Journal of Biological Chemistry. 275 (29): 22503–22511. doi: 10.1074/jbc.M001698200 . PMID 10801818.
↑ Hwang T, Parker SS, Hill SM, Ilunga MW, Grant RA, Mouneimne G, Keating AE (December 2021). "A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers". eLife. 10: e70601. doi: 10.7554/eLife.70601 . PMC 8639148 . PMID 34854809.

Niebuhr K, Ebel F, Frank R, Reinhard M, Domann E, Carl UD, et al. (September 1997). "A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family". The EMBO Journal. 16 (17): 5433–5444. doi:10.1093/emboj/16.17.5433. PMC 1170174 . PMID 9312002.
Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M (December 1997). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled". The Journal of Biological Chemistry. 272 (52): 32869–32877. doi: 10.1074/jbc.272.52.32869 . PMID 9407065.
Mammoto A, Sasaki T, Asakura T, Hotta I, Imamura H, Takahashi K, et al. (February 1998). "Interactions of drebrin and gephyrin with profilin". Biochemical and Biophysical Research Communications. 243 (1): 86–89. doi:10.1006/bbrc.1997.8068. PMID 9473484.
Geese M, Schlüter K, Rothkegel M, Jockusch BM, Wehland J, Sechi AS (April 2000). "Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed". Journal of Cell Science. 113 ( Pt 8) (8): 1415–1426. doi:10.1242/jcs.113.8.1415. PMID 10725224.
Krause M, Sechi AS, Konradt M, Monner D, Gertler FB, Wehland J (April 2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton". The Journal of Cell Biology. 149 (1): 181–194. doi:10.1083/jcb.149.1.181. PMC 2175102 . PMID 10747096.
Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (July 2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". The Journal of Biological Chemistry. 275 (29): 22503–22511. doi: 10.1074/jbc.M001698200 . PMID 10801818.
Krugmann S, Jordens I, Gevaert K, Driessens M, Vandekerckhove J, Hall A (October 2001). "Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex". Current Biology. 11 (21): 1645–1655. doi: 10.1016/S0960-9822(01)00506-1 . PMID 11696321. S2CID 11290377.
Coutts AS, MacKenzie E, Griffith E, Black DM (March 2003). "TES is a novel focal adhesion protein with a role in cell spreading". Journal of Cell Science. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287. S2CID 26602119.
Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (June 2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". The Journal of Biological Chemistry. 278 (24): 21685–21692. doi: 10.1074/jbc.M301447200 . PMID 12672821.
Garvalov BK, Higgins TE, Sutherland JD, Zettl M, Scaplehorn N, Köcher T, et al. (April 2003). "The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions". The Journal of Cell Biology. 161 (1): 33–39. doi:10.1083/jcb.200211015. PMC 2172870 . PMID 12695497.
Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, et al. (September 2003). "Robo4 is a vascular-specific receptor that inhibits endothelial migration". Developmental Biology. 261 (1): 251–267. doi: 10.1016/S0012-1606(03)00258-6 . PMID 12941633.
Giesemann T, Schwarz G, Nawrotzki R, Berhörster K, Rothkegel M, Schlüter K, et al. (September 2003). "Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system". The Journal of Neuroscience. 23 (23): 8330–8339. doi:10.1523/JNEUROSCI.23-23-08330.2003. PMC 6740687 . PMID 12967995.
Salazar MA, Kwiatkowski AV, Pellegrini L, Cestra G, Butler MH, Rossman KL, et al. (December 2003). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton". The Journal of Biological Chemistry. 278 (49): 49031–49043. doi: 10.1074/jbc.M308104200 . PMID 14506234.
Stüven T, Hartmann E, Görlich D (November 2003). "Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes". The EMBO Journal. 22 (21): 5928–5940. doi:10.1093/emboj/cdg565. PMC 275422 . PMID 14592989.
Di Modugno F, Bronzi G, Scanlan MJ, Del Bello D, Cascioli S, Venturo I, et al. (May 2004). "Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response". International Journal of Cancer. 109 (6): 909–918. doi: 10.1002/ijc.20094 . PMID 15027125.
Tanoue T, Takeichi M (May 2004). "Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact". The Journal of Cell Biology. 165 (4): 517–528. doi:10.1083/jcb.200403006. PMC 2172355 . PMID 15148305.
Krause M, Leslie JD, Stewart M, Lafuente EM, Valderrama F, Jagannathan R, et al. (October 2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics". Developmental Cell. 7 (4): 571–583. doi: 10.1016/j.devcel.2004.07.024 . PMID 15469845.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000154380 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022995 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1420303-5] Sazuka T, Tomooka Y, Kathju S, Ikawa Y, Noda M, Kumar S (October 1992). "Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1132 (3): 240–248. doi:10.1016/0167-4781(92)90156-t. hdl: 2027.42/29785 . PMID 1420303.

[entrez-6] "Entrez Gene: ENAH enabled homolog (Drosophila)".

[pmid12672821-7] 1 2 Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (June 2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". The Journal of Biological Chemistry. 278 (24): 21685–21692. doi: 10.1074/jbc.M301447200 . PMID 12672821.

[pmid10801818-8] Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (July 2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". The Journal of Biological Chemistry. 275 (29): 22503–22511. doi: 10.1074/jbc.M001698200 . PMID 10801818.

[9] Hwang T, Parker SS, Hill SM, Ilunga MW, Grant RA, Mouneimne G, Keating AE (December 2021). "A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers". eLife. 10: e70601. doi: 10.7554/eLife.70601 . PMC 8639148 . PMID 34854809.

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ENAH (gene)

Contents

Interactions

Related Research Articles

References

Further reading