ABI1

ABI1
Identifiers
Aliases	ABI1 , ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1, abl interactor 1
External IDs	OMIM: 603050 MGI: 104913 HomoloGene: 38053 GeneCards: ABI1
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10p12.1 Start 26,746,593 bp [1] End 26,861,087 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 A3|2 15.18 cM Start 22,830,085 bp [2] End 22,930,253 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid palpebral conjunctiva cavity of mouth bronchial epithelial cell bone marrow thymus human penis jejunal mucosa gums hair follicle Top expressed in subiculum left lung lobe parotid gland ventral tegmental area olfactory tubercle cerebellar vermis pyloric antrum globus pallidus left colon epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine kinase activator activity protein-containing complex binding cytoskeletal protein binding protein binding SH3 domain binding cadherin binding Cellular component cytoplasm cytosol postsynaptic membrane cell projection postsynaptic density SCAR complex membrane filopodium growth cone plasma membrane synapse intracellular anatomical structure cell junction cell leading edge endoplasmic reticulum neuron projection extracellular exosome cytoskeleton nucleus lamellipodium filopodium tip Biological process somitogenesis megakaryocyte development Fc-gamma receptor signaling pathway involved in phagocytosis transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of protein tyrosine kinase activity vascular endothelial growth factor receptor signaling pathway peptidyl-tyrosine phosphorylation viral process lamellipodium morphogenesis negative regulation of cell population proliferation dendrite morphogenesis actin polymerization or depolymerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10006 11308 Ensembl ENSG00000136754 ENSMUSG00000058835 UniProt Q8IZP0 Q8CBW3 RefSeq (mRNA) NM_001012750 NM_001012751 NM_001012752 NM_001178116 NM_001178119 NM_001178120 NM_001178121 NM_001178122 NM_001178123 NM_001178124 NM_001178125 NM_005470 NM_001348029 NM_001348030 NM_001348031 NM_001348032 NM_001348033 NM_001348034 NM_001077190 NM_001077192 NM_001077193 NM_007380 NM_145994 NM_001331043 NM_001331044 NM_001331045 NM_001377510 NM_001377511 NM_001377512 NM_001377513 RefSeq (protein) NP_001012768 NP_001012769 NP_001012770 NP_001171587 NP_001171590 NP_001171591 NP_001171592 NP_001171593 NP_001171594 NP_001171595 NP_001171596 NP_005461 NP_001334958 NP_001334959 NP_001334960 NP_001334961 NP_001334962 NP_001334963 NP_001070658 NP_001070660 NP_001070661 NP_001317972 NP_001317973 NP_001317974 NP_031406 NP_666106 NP_001364439 NP_001364440 NP_001364441 NP_001364442 Location (UCSC) Chr 10: 26.75 – 26.86 Mb Chr 2: 22.83 – 22.93 Mb PubMed search [3] [4]
Wikidata
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Abl interactor 1 also known as Abelson interactor 1 (Abi-1) is a protein that in humans is encoded by the ABI1 gene. ^{[5] [6]}

Function

Abl interactor 1 has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling. Several transcript variants encoding multiple isoforms have been found for this gene. ^[7]

Abi1 is adaptor protein. It interacts with c-Abl and WAVE2 which is an actin polymerization regulator. It is known that Abi1 enhances the phosphorylation of WAVE2 by c-Abl. The phosphorylation of c-Abl promotes actin polymerization. Furthermore, Abi1 is a component of the WAVE complex. Some research has shown that knockdown of Abi1 by siRNA promoted degradation of WAVE complex proteins.^{[ citation needed ]}

Interactions

ABI1 has been shown to interact with

ENAH, ^[8] NCKAP1, ^[9] EPS8, ^{[6] [8] [9] [10] [11]} and SOS1. ^[12]

References

1. GRCh38: Ensembl release 89: ENSG00000136754 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058835 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ziemnicka-Kotula D, Xu J, Gu H, Potempska A, Kim KS, Jenkins EC, Trenkner E, Kotula L (Jul 1998). "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton". J Biol Chem. 273 (22): 13681–92. doi: 10.1074/jbc.273.22.13681 . PMID   9593709.
6. Biesova Z, Piccoli C, Wong WT (Feb 1997). "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth". Oncogene. 14 (2): 233–41. doi: 10.1038/sj.onc.1200822 . PMID   9010225.
7. "Entrez Gene: ABI1 abl-interactor 1".
8. Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (June 2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". J. Biol. Chem. 278 (24): 21685–92. doi: 10.1074/jbc.M301447200 . PMID   12672821.
9. Yamamoto A, Suzuki T, Sakaki Y (June 2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease". Gene. 271 (2): 159–69. doi:10.1016/S0378-1119(01)00521-2. PMID   11418237.
10. Offenhäuser N, Borgonovo A, Disanza A, Romano P, Ponzanelli I, Iannolo G, Di Fiore PP, Scita G (January 2004). "The eps8 Family of Proteins Links Growth Factor Stimulation to Actin Reorganization Generating Functional Redundancy in the Ras/Rac Pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC   307530 . PMID   14565974.
11. Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP (November 2000). "The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5". Nature. 408 (6810): 374–7. Bibcode:2000Natur.408..374L. doi:10.1038/35042605. PMID   11099046. S2CID   4405293.
12. Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, Gutkind S, Bjarnegård M, Betsholtz C, Di Fiore PP (September 1999). "EPS8 and E3B1 transduce signals from Ras to Rac". Nature. 401 (6750): 290–3. Bibcode:1999Natur.401..290S. doi:10.1038/45822. PMID   10499589. S2CID   205045006.

Further reading

• Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S (2002). "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review)". Int. J. Mol. Med. 9 (6): 591–5. doi:10.3892/ijmm.9.6.591. PMID   12011975.
• Di Fiore PP, Scita G (2002). "Eps8 in the midst of GTPases". Int. J. Biochem. Cell Biol. 34 (10): 1178–83. doi:10.1016/S1357-2725(02)00064-X. PMID   12127568.
• Cardwell C (1977). "Student or worker? International Meeting of Student Nurses (European Group)". Nursing Mirror and Midwives Journal. 143 (19): 38. PMID   1049958.
• Biesova Z, Piccoli C, Wong WT (1997). "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth". Oncogene. 14 (2): 233–41. doi: 10.1038/sj.onc.1200822 . PMID   9010225.
• Taki T, Shibuya N, Taniwaki M, et al. (1998). "ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23)". Blood. 92 (4): 1125–30. doi:10.1182/blood.V92.4.1125. PMID   9694699.
• Scita G, Nordstrom J, Carbone R, et al. (1999). "EPS8 and E3B1 transduce signals from Ras to Rac". Nature. 401 (6750): 290–3. Bibcode:1999Natur.401..290S. doi:10.1038/45822. PMID   10499589. S2CID   205045006.
• Courtney KD, Grove M, Vandongen H, et al. (2000). "Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system". Mol. Cell. Neurosci. 16 (3): 244–57. doi:10.1006/mcne.2000.0865. PMID   10995551. S2CID   7370589.
• Fan PD, Goff SP (2000). "Abl Interactor 1 Binds to Sos and Inhibits Epidermal Growth Factor- and v-Abl-Induced Activation of Extracellular Signal-Regulated Kinases". Mol. Cell. Biol. 20 (20): 7591–601. doi:10.1128/MCB.20.20.7591-7601.2000. PMC   86315 . PMID   11003655.
• Xu J, Ziemnicka D, Merz GS, Kotula L (2001). "Human spectrin Src homology 3 domain binding protein 1 regulates macropinocytosis in NIH 3T3 cells". J. Cell Sci. 113 (21): 3805–14. doi:10.1242/jcs.113.21.3805. PMC   4511602 . PMID   11034908.
• Lanzetti L, Rybin V, Malabarba MG, et al. (2000). "The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5". Nature. 408 (6810): 374–7. Bibcode:2000Natur.408..374L. doi:10.1038/35042605. PMID   11099046. S2CID   4405293.
• Yamamoto A, Suzuki T, Sakaki Y (2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease". Gene. 271 (2): 159–69. doi:10.1016/S0378-1119(01)00521-2. PMID   11418237.
• Cowan CA, Henkemeyer M (2001). "The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals". Nature. 413 (6852): 174–9. Bibcode:2001Natur.413..174C. doi:10.1038/35093123. PMID   11557983. S2CID   4313061.
• Ichigotani Y, Yokozaki S, Fukuda Y, et al. (2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells". Cancer Res. 62 (8): 2215–9. PMID   11956071.
• Mammalian Gene Collection Program Team, Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences . 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Salomon AR, Ficarro SB, Brill LM, et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. Bibcode:2003PNAS..100..443S. doi: 10.1073/pnas.2436191100 . PMC   141014 . PMID   12522270.
• Morerio C, Rosanda C, Rapella A, et al. (2003). "Is t(10;11)(p11.2;q23) involving MLL and ABI-1 genes associated with congenital acute monocytic leukemia?". Cancer Genet. Cytogenet. 139 (1): 57–9. doi:10.1016/S0165-4608(02)00616-7. PMID   12547160.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.

External links

• ABI1 human gene location in the UCSC Genome Browser .
• ABI1 human gene details in the UCSC Genome Browser .