ENSA (gene)

Last updated

ENSA
Identifiers
Aliases ENSA , ARPP-19e, endosulfine alpha
External IDs OMIM: 603061; MGI: 1891189; HomoloGene: 37924; GeneCards: ENSA; OMA:ENSA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001026212
NM_019561

RefSeq (protein)

NP_001021383
NP_062507

Location (UCSC) Chr 1: 150.6 – 150.63 Mb Chr 3: 95.53 – 95.54 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Alpha-endosulfine is a protein that in humans is encoded by the ENSA gene. [5] [6]

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143420 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038619 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Heron L, Virsolvy A, Peyrollier K, Gribble FM, Le Cam A, Ashcroft FM, Bataille D (Aug 1998). "Human α-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: Molecular cloning, expression and biological properties". Proc Natl Acad Sci U S A. 95 (14): 8387–91. Bibcode:1998PNAS...95.8387H. doi: 10.1073/pnas.95.14.8387 . PMC   20985 . PMID   9653196.
  6. 1 2 "Entrez Gene: ENSA endosulfine alpha".

Further reading