ERG28

Last updated
ERG28
Identifiers
Aliases ERG28 , NET51, C14orf1, chromosome 14 open reading frame 1, ergosterol biosynthesis 28 homolog
External IDs OMIM: 604576 MGI: 1915571 HomoloGene: 38284 GeneCards: ERG28
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007176

NM_021446
NM_001360451
NM_001360813

RefSeq (protein)

NP_009107

NP_067421
NP_001347380
NP_001347742

Location (UCSC) Chr 14: 75.65 – 75.66 Mb n/a
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Ergosterol biosynthetic protein 28 is a protein that in humans is encoded by the ERG28 gene. [4] [5] [6] [7]

Contents

Related Research Articles

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Glutathione S-transferase kappa 1 (GSTK1) is an enzyme that in humans is encoded by the GSTK1 gene which is located on chromosome seven. It belongs to the superfamily of enzymes known as glutathione S-transferase (GST), which are mainly known for cellular detoxification. The GSTK1 gene consists of eight exons and seven introns and although it is a member of the GST family, its structure has been found to be similar to bacterial HCCA (2-hydroxychromene-2-carboxylate) isomerases and bacterial disulphide-bond-forming DsbA oxidoreductase. This similarity has later allowed the enzyme GSTK1 to be renamed to DsbA-L. Research has also suggested that several variations of the GSTK1 gene can be responsible for metabolic diseases and certain types of cancer.

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YIPF3

Protein YIPF3 is a protein that in humans is encoded by the YIPF3 gene. Along with YIPF4, it is concentrated in the cis-Golgi region. There the two form a complex and may be involved in the maintenance of the Golgi structure.

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TIMMDC1 is a protein that in humans is encoded by the TIMMDC1 gene. It is a chaperone protein involved in constructing the membrane arm of mitochondrial Complex I. A frameshift mutation in an intron of this gene has been shown to cause failure to thrive, retardation of psychomotor development, infantile-onset hypotonia, and severe neurologic dysfunction. High expression of this gene has been associated with migration of lung cancer cells while depletion of the protein has been shown to affect regulation of apoptosis, the cell cycle, and cell migration.

TMEM47

Transmembrane protein 47 is a protein that in humans is encoded by the TMEM47 gene.

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SEC61G

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SPRTN

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Mitochondrial pyruvate carrier 2

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000133935 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Veitia RA, Ottolenghi C, Bissery MC, Fellous A (Oct 1999). "A novel human gene, encoding a potential membrane protein conserved from yeast to man, is strongly expressed in testis and cancer cell lines". Cytogenetics and Cell Genetics. 85 (3–4): 217–20. doi:10.1159/000015296. PMID   10449901. S2CID   45886286.
  5. Schirmer EC, Florens L, Guan T, Yates JR, Gerace L (Sep 2003). "Nuclear membrane proteins with potential disease links found by subtractive proteomics". Science. 301 (5638): 1380–2. doi:10.1126/science.1088176. PMID   12958361. S2CID   23832536.
  6. Gachotte D, Eckstein J, Barbuch R, Hughes T, Roberts C, Bard M (Jan 2001). "A novel gene conserved from yeast to humans is involved in sterol biosynthesis". Journal of Lipid Research. 42 (1): 150–4. doi:10.1016/S0022-2275(20)32347-6. PMID   11160377.
  7. "Entrez Gene: C14orf1 chromosome 14 open reading frame 1".

Further reading