EXOC1

EXOC1
Identifiers
Aliases	EXOC1 , BM-102, SEC3, SEC3L1, SEC3P, exocyst complex component 1
External IDs	OMIM: 607879 MGI: 2445020 HomoloGene: 41241 GeneCards: EXOC1
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q12 Start 55,853,648 bp [1] End 55,905,086 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 C3.3|5 Start 76,529,311 bp [2] End 76,570,294 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cavity of mouth Achilles tendon parietal pleura visceral pleura inferior olivary nucleus germinal epithelium corpus callosum palpebral conjunctiva jejunal mucosa vulva Top expressed in secondary oocyte spermatocyte superior frontal gyrus facial motor nucleus saccule ganglionic eminence cerebellar cortex mirror otic placode neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-4,5-bisphosphate binding protein binding Cellular component cytoplasmic side of apical plasma membrane cytosol plasma membrane membrane exocyst cytoplasm perinuclear region of cytoplasm Flemming body Biological process protein transport exocyst localization Golgi to plasma membrane transport regulation of macroautophagy phosphatidylinositol-mediated signaling positive regulation of protein secretion exocytosis transport viral process defense response to virus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55763 69940 Ensembl ENSG00000090989 ENSMUSG00000036435 UniProt Q9NV70 Q8R3S6 RefSeq (mRNA) NM_001024924 NM_018261 NM_178237 NM_001289770 NM_001289771 NM_027270 NM_001359370 NM_001359372 NM_001359373 RefSeq (protein) NP_001020095 NP_060731 NP_839955 NP_001276699 NP_001276700 NP_081546 NP_001346299 NP_001346301 NP_001346302 NP_001388254 NP_001388255 Location (UCSC) Chr 4: 55.85 – 55.91 Mb Chr 5: 76.53 – 76.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Exocyst complex component 1 is a protein that in humans is encoded by the EXOC1 gene. ^{[5] [6] [7]}

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000090989 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036435 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
6. Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ (Aug 2001). "The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene". J Biol Chem. 276 (32): 29792–7. doi:10.1074/jbc.C100320200. PMID   11406615.
7. "Entrez Gene: EXOC1 exocyst complex component 1".

Further reading

• Hsu SC, TerBush D, Abraham M, Guo W (2004). "The exocyst complex in polarized exocytosis". Int. Rev. Cytol. International Review of Cytology. 233: 243–65. doi:10.1016/S0074-7696(04)33006-8. ISBN   978-0-12-364637-8. PMID   15037366.
• Kee Y, Yoo JS, Hazuka CD, et al. (1998). "Subunit structure of the mammalian exocyst complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14438–43. doi: 10.1073/pnas.94.26.14438 . PMC   25013 . PMID   9405631.
• Hsu SC, Hazuka CD, Roth R, et al. (1998). "Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments". Neuron. 20 (6): 1111–22. doi: 10.1016/S0896-6273(00)80493-6 . PMID   9655500. S2CID   10915358.
• Matern HT, Yeaman C, Nelson WJ, Scheller RH (2001). "The Sec6/8 complex in mammalian cells: Characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9648–53. doi: 10.1073/pnas.171317898 . PMC   55506 . PMID   11493706.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Inoue M, Chang L, Hwang J, et al. (2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin" (PDF). Nature. 422 (6932): 629–33. Bibcode:2003Natur.422..629I. doi:10.1038/nature01533. hdl: 2027.42/62982 . PMID   12687004. S2CID   4395760.
• Moskalenko S, Tong C, Rosse C, et al. (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi: 10.1074/jbc.M308702200 . PMID   14525976.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.