EXOC2

EXOC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HK6
Identifiers
Aliases	EXOC2 , SEC5, SEC5L1, Sec5p, exocyst complex component 2, NEDFACH
External IDs	OMIM: 615329 MGI: 1913732 HomoloGene: 10122 GeneCards: EXOC2
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p25.3 Start 485,154 bp [1] End 693,139 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 A3.2 Start 30,997,902 bp [2] End 31,158,076 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus secondary oocyte Brodmann area 23 islet of Langerhans ganglionic eminence Achilles tendon stromal cell of endometrium monocyte corpus callosum prefrontal cortex Top expressed in hand otolith organ utricle superior cervical ganglion spermatocyte spermatid thymus secondary oocyte medial ganglionic eminence Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase binding protein N-terminus binding Cellular component cytosol plasma membrane exocyst membrane Flemming body Biological process protein transport regulation of entry of bacterium into host cell Golgi to plasma membrane transport exocyst assembly exocytosis transport vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55770 66482 Ensembl ENSG00000112685 ENSMUSG00000021357 UniProt Q96KP1 Q9D4H1 RefSeq (mRNA) NM_018303 NM_025588 NM_001360093 RefSeq (protein) NP_060773 NP_079864 NP_001347022 Location (UCSC) Chr 6: 0.49 – 0.69 Mb Chr 13: 31 – 31.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Exocyst complex component 2 is a protein that in humans is encoded by the EXOC2 gene. ^{[5] [6] [7]}

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000112685 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021357 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Murthy M, Garza D, Scheller RH, Schwarz TL (Feb 2003). "Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists". Neuron. 37 (3): 433–47. doi: 10.1016/S0896-6273(03)00031-X . PMID   12575951. S2CID   14351315.
6. Sjolinder M, Uhlmann J, Ponstingl H (Dec 2002). "DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion". FEBS Lett. 532 (1–2): 211–5. doi: 10.1016/S0014-5793(02)03677-3 . PMID   12459492. S2CID   31552100.
7. "Entrez Gene: EXOC2 exocyst complex component 2".

Further reading

• Hsu SC, TerBush D, Abraham M, Guo W (2004). "The exocyst complex in polarized exocytosis". Int. Rev. Cytol. International Review of Cytology. 233: 243–65. doi:10.1016/S0074-7696(04)33006-8. ISBN   978-0-12-364637-8. PMID   15037366.
• Kee Y, Yoo JS, Hazuka CD, et al. (1998). "Subunit structure of the mammalian exocyst complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14438–43. doi: 10.1073/pnas.94.26.14438 . PMC   25013 . PMID   9405631.
• Hsu SC, Hazuka CD, Roth R, et al. (1998). "Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments". Neuron. 20 (6): 1111–22. doi: 10.1016/S0896-6273(00)80493-6 . PMID   9655500. S2CID   10915358.
• Matern HT, Yeaman C, Nelson WJ, Scheller RH (2001). "The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9648–53. doi: 10.1073/pnas.171317898 . PMC   55506 . PMID   11493706.
• Sugihara K, Asano S, Tanaka K, et al. (2002). "The exocyst complex binds the small GTPase RalA to mediate filopodia formation". Nat. Cell Biol. 4 (1): 73–8. doi:10.1038/ncb720. PMID   11744922. S2CID   9528945.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mott HR, Nietlispach D, Hopkins LJ, et al. (2003). "Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site" (PDF). J. Biol. Chem. 278 (19): 17053–9. doi: 10.1074/jbc.M300155200 . PMID   12624092.
• Inoue M, Chang L, Hwang J, et al. (2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin" (PDF). Nature. 422 (6932): 629–33. Bibcode:2003Natur.422..629I. doi:10.1038/nature01533. hdl: 2027.42/62982 . PMID   12687004. S2CID   4395760.
• Fukai S, Matern HT, Jagath JR, et al. (2003). "Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex". EMBO J. 22 (13): 3267–78. doi:10.1093/emboj/cdg329. PMC   165653 . PMID   12839989.
• Moskalenko S, Tong C, Rosse C, et al. (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi: 10.1074/jbc.M308702200 . PMID   14525976.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi: 10.1038/nature02055 . PMID   14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Jin R, Junutula JR, Matern HT, et al. (2005). "Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase". EMBO J. 24 (12): 2064–74. doi:10.1038/sj.emboj.7600699. PMC   1150893 . PMID   15920473.
• Chien Y, Kim S, Bumeister R, et al. (2006). "RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival". Cell. 127 (1): 157–70. doi: 10.1016/j.cell.2006.08.034 . PMID   17018283. S2CID   9878037.
• Sulem P, Gudbjartsson DF, Stacey SN, et al. (2007). "Genetic determinants of hair, eye and skin pigmentation in Europeans". Nat. Genet. 39 (12): 1443–52. doi:10.1038/ng.2007.13. PMID   17952075. S2CID   19313549.