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A blister is a small pocket of body fluid within the upper layers of the skin, usually caused by forceful rubbing (friction), burning, freezing, chemical exposure or infection. Most blisters are filled with a clear fluid, either serum or plasma. However, blisters can be filled with blood or with pus.
A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. The major function of this system is as a barrier against the external environment.
Epidermolysis bullosa simplex (EBS) is a disorder resulting from mutations in the genes encoding keratin 5 or keratin 14.
Pemphigoid is a group of rare autoimmune blistering diseases of the skin, and mucous membranes. As its name indicates, pemphigoid is similar in general appearance to pemphigus, but, unlike pemphigus, pemphigoid does not feature acantholysis, a loss of connections between skin cells.
Kindler syndrome is a rare congenital disease of the skin caused by a mutation in the KIND1 gene.
The Asboe-Hansen sign refers to the extension of a large blister to adjacent unblistered skin when pressure is put on the top of it. It is seen along with Nikolsky's sign, both used to assess the severity of some blistering diseases such as pemphigus vulgaris and severe bullous drug reactions.
Acne with facial edema occurs uncommonly, and is associated with a peculiar inflammatory edema of the mid-third of the face.
Cutaneous small-vessel vasculitis (CSVV), is inflammation of small blood vessels, usually accompanied by small lumps beneath the skin. The condition is also known as hypersensitivity vasculitis, cutaneous leukocytoclastic vasculitis, hypersensitivity angiitis, cutaneous leukocytoclastic angiitis, cutaneous necrotizing vasculitis and cutaneous necrotizing venulitis,
Acute hemorrhagic edema of infancy is a skin condition that affects children under the age of two with a recent history of upper respiratory illness, a course of antibiotics, or both. The disease was first described in 1938 by Finkelstein and later by Seidlmayer as "Seidlmayer cockade purpura".
Friction blisters are a skin condition that may occur at sites of combined pressure and friction, and may be enhanced by heat, moisture, or cotton socks. Friction blisters are characterized by vesicles or bullae.
A diabetic bulla is a cutaneous condition characterized by a noninflammatory, spontaneous, painless blister, often in acral locations, seen in diabetic patients.
Diabetic dermadromes constitute a group of cutaneous conditions commonly seen in people with diabetes with longstanding disease. Conditions included in this group are:
Angina bullosa haemorrhagica is a condition of the mucous membranes characterized by the sudden appearance of one or more blood blisters within the oral cavity. The lesions, which may be caused by mild trauma to the mouth tissues such as hot foods, typically rupture quickly and heal without scarring or further discomfort. The condition is not serious except in rare cases where a large bulla that does not rupture spontaneously may cause airway obstruction.
Heat edema is a cutaneous condition characterized by dependent edema from vasodilatory pooling. Heat causes the blood vessels to expand (dilate), so body fluid moves into the hands or legs by gravity.
A coma blister, or coma bullae, is a skin lesion or blister that typically arises due to pressure in an individual with impaired consciousness. They vary in size, ranging from 4 to 5 centimeters in diameter, and may appear hemorrhagic or blood filled. Coma blisters are usually found in the extremities and trunk. These types of blisters have been associated with the overdose of central nervous system (CNS) depressants especially barbiturates, but also tricyclic antidepressants, hypnotics, benzodiazepines, opiates, antipsychotics, and alcohol. However, studies have found that coma blisters are not caused by the toxicity of these drugs, but due to hypoxia and external pressure on the comatose individual's skin from being immobilized. Coma blisters have been frequently found on individuals who have overdosed on drugs, but have also been found on individuals with chronic kidney failure, hypercalcemia, diabetic ketoacidosis, and a variety of neurologic conditions. Coma blisters are more frequent in adults and less common among children as demonstrated by the few cases published in literature.
Delayed blisters are a cutaneous condition observed weeks to months after the initial healing of second-degree thermal burns, donor sites of split-thickness skin grafts, and recipient sites of split-thickness skin grafts.
PUVA-induced acrobullous dermatosis is a cutaneous condition characterized by the sudden occurrence of tense blisters, usually on the distal extremities, during long-term PUVA therapy
Skin fragility syndrome is a cutaneous condition characterized by trauma-induced blisters and erosions.
Mucous membrane pemphigoid is a rare chronic autoimmune subepithelial blistering disease characterized by erosive lesions of the mucous membranes and skin. It is one of the pemphigoid diseases that can result in scarring.
References
- ↑ 'Oedema' is the standard form defined in the Concise Oxford English Dictionary (2011), with the precision that the spelling in the United States is 'edema'.
- ↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 472. ISBN 978-1-4160-2999-1.
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